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Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.
Flint M, McMullan LK, Dodd KA, Bird BH, Khristova ML, Nichol ST, Spiropoulou CF. Flint M, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3206-16. doi: 10.1128/AAC.02393-14. Epub 2014 Mar 24. Antimicrob Agents Chemother. 2014. PMID: 24663025 Free PMC article.
The S603T/C666S mutant had a reduced level of replication which was increased when M644V was also present, although the replication of this triple mutant was still below that of the wild type. The S603 and C666 residues were predicted to lie in the active site of the AHFV …
The S603T/C666S mutant had a reduced level of replication which was increased when M644V was also present, although the replication of this …
In-silico design of envelope based multi-epitope vaccine candidate against Kyasanur forest disease virus.
Arumugam S, Varamballi P. Arumugam S, et al. Sci Rep. 2021 Aug 24;11(1):17118. doi: 10.1038/s41598-021-94488-8. Sci Rep. 2021. PMID: 34429443 Free PMC article.
In this study, we did in-silico design of multi-epitope subunit vaccine for KFDV. B-cell and T-cell epitopes were predicted from conserved regions of KFDV envelope protein and two vaccine candidates (VC1 and VC2) were constructed, those were found to be non-allergic and po …
In this study, we did in-silico design of multi-epitope subunit vaccine for KFDV. B-cell and T-cell epitopes were predicted from cons …