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1959 1
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2012 5
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Page 1
Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency.
Deben DS, Derijks LJJ, van den Bosch BJC, Creemers RH, van Nunen A, van Bodegraven AA, Wong DR. Deben DS, et al. Metabolites. 2023 Oct 6;13(10):1054. doi: 10.3390/metabo13101054. Metabolites. 2023. PMID: 37887379 Free PMC article.
Of these patients, 12 intermediate and 4 poor TPMT metabolisers had been prescribed tioguanine in varying doses. In one poor TPMT metaboliser, tioguanine 10 mg/day induced delayed pancytopenia. ...Diminished or absent TPMT enzyme activity was related with a pharmaco …
Of these patients, 12 intermediate and 4 poor TPMT metabolisers had been prescribed tioguanine in varying doses. In one poor TPMT met …
Thioguanine.
[No authors listed] [No authors listed] 2017 Aug 17. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Aug 17. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643821 Free Books & Documents. Review.
Thioguanine (also referred to as 6-thioguanine and as tioguanine) is a purine analogue that is used in the therapy of acute and chronic myelogenous leukemias. ...
Thioguanine (also referred to as 6-thioguanine and as tioguanine) is a purine analogue that is used in the therapy of acute and chron …
Thioguanine.
[No authors listed] [No authors listed] 2024 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2024 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 29999719 Free Books & Documents. Review.
Reduction-sensitive tioguanine prodrug micelles.
van der Vlies AJ, Hasegawa U, Hubbell JA. van der Vlies AJ, et al. Mol Pharm. 2012 Oct 1;9(10):2812-8. doi: 10.1021/mp3001183. Epub 2012 Sep 17. Mol Pharm. 2012. PMID: 22954101
The polymers self-assembled when dispersed in water to form tioguanine prodrug micelles with a size range between 18 and 40 nm that released tioguanine in response to cysteine and serum as shown spectroscopically. In comparison with a poly(ethylene glycol) prodrug p …
The polymers self-assembled when dispersed in water to form tioguanine prodrug micelles with a size range between 18 and 40 nm that r …
A comparative analysis of tioguanine versus low-dose thiopurines combined with allopurinol in inflammatory bowel disease patients.
Biemans VBC, Savelkoul E, Gabriëls RY, Simsek M, Dijkstra G, Pierik MJ, West RL, de Boer NKH, Hoentjen F. Biemans VBC, et al. Aliment Pharmacol Ther. 2020 Jun;51(11):1076-1086. doi: 10.1111/apt.15730. Epub 2020 Apr 27. Aliment Pharmacol Ther. 2020. PMID: 32339331 Free PMC article.
IBD patients who failed conventional thiopurines due to adverse events and initiated tioguanine were enrolled in three university hospitals. Patients on concomitant biologicals were excluded. ...Of these, 19% (tioguanine: 20%, LDTA: 18%) of patients discontinued the …
IBD patients who failed conventional thiopurines due to adverse events and initiated tioguanine were enrolled in three university hos …
Favourable Tolerability and Drug Survival of Tioguanine Versus Methotrexate After Failure of Conventional Thiopurines in Crohn's Disease.
Savelkoul EHJ, Maas MHJ, Bourgonje AR, Crouwel F, Biemans VBC, den Broeder N, Russel MGVM, Römkens TEH, de Boer NK, Dijkstra G, Hoentjen F. Savelkoul EHJ, et al. J Crohns Colitis. 2022 Sep 8;16(9):1372-1379. doi: 10.1093/ecco-jcc/jjac044. J Crohns Colitis. 2022. PMID: 35303065 Free PMC article.
RESULTS: In total, 219 patients starting either methotrexate [n = 105] or tioguanine [n = 114] were included. In all 65 [29.7%] patients (methotrexate 43.8% [46/105 people], tioguanine 16.7% [19/114 people], p <0.001) discontinued their treatment due to adverse e …
RESULTS: In total, 219 patients starting either methotrexate [n = 105] or tioguanine [n = 114] were included. In all 65 [29.7%] patie …
6-tioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine.
Roblin X, Serre-Debeauvais F, Phelip JM, Faucheron JL, Hardy G, Chartier A, Helluwaert F, Bessard G, Bonaz B. Roblin X, et al. Aliment Pharmacol Ther. 2005 Apr 1;21(7):829-39. doi: 10.1111/j.1365-2036.2005.02419.x. Aliment Pharmacol Ther. 2005. PMID: 15801918 Free article.
BACKGROUND: 6-Thioguanine (6-tioguanine) nucleotides are the active metabolites of azathioprine. ...In the multivariate analysis, only a 6-tioguanine level of >250 pmol/8 x 10(8) red blood cells was a predictive factor of favourable clinical remission. ...
BACKGROUND: 6-Thioguanine (6-tioguanine) nucleotides are the active metabolites of azathioprine. ...In the multivariate analysis, onl …
Safety of Tioguanine During Pregnancy in Inflammatory Bowel Disease.
van den Berg SA, de Boer M, van der Meulen-de Jong AE, Jansen JM, Hoentjen F, Russel MG, Mahmmod N, van Bodegraven AA, van der Woude CJ, Mulder CJ, de Boer NK. van den Berg SA, et al. J Crohns Colitis. 2016 Feb;10(2):159-65. doi: 10.1093/ecco-jcc/jjv189. Epub 2015 Oct 26. J Crohns Colitis. 2016. PMID: 26503525
BACKGROUND AND AIMS: Conventional thiopurine [azathioprine and mercaptopurine] treatment during pregnancy in patients with inflammatory bowel disease [IBD] is considered to be safe; however data on the safety and teratogenicity of the non-conventional thiopurine tioguanine …
BACKGROUND AND AIMS: Conventional thiopurine [azathioprine and mercaptopurine] treatment during pregnancy in patients with inflammatory bowe …
53 results