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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 2
1979 1
1980 4
1981 10
1982 12
1983 13
1984 18
1985 16
1986 10
1987 7
1988 3
1989 11
1990 6
1991 14
1992 9
1993 4
1994 12
1995 9
1996 10
1997 6
1998 4
1999 13
2000 11
2001 3
2002 14
2003 16
2004 19
2005 13
2006 14
2007 17
2008 19
2009 13
2010 19
2011 21
2012 17
2013 20
2014 16
2015 10
2016 14
2017 17
2018 15
2019 12
2020 13
2021 15
2022 15
2023 16
2024 4

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513 results

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Page 1
Update on the use of trilostane in dogs.
Lemetayer J, Blois S. Lemetayer J, et al. Can Vet J. 2018 Apr;59(4):397-407. Can Vet J. 2018. PMID: 29606727 Free PMC article. Review.
Because the duration of cortisol suppression after a dose of trilostane is often less than 12 hours, many dogs with HAC could benefit from low dose trilostane treatment every 12 hours. Many controversies regarding trilostane still exist. This review provides …
Because the duration of cortisol suppression after a dose of trilostane is often less than 12 hours, many dogs with HAC could benefit …
Pre-trilostane and three-hour post-trilostane cortisol to monitor trilostane therapy in dogs.
Macfarlane L, Parkin T, Ramsey I. Macfarlane L, et al. Vet Rec. 2016 Dec 10;179(23):597. doi: 10.1136/vr.103744. Epub 2016 Nov 1. Vet Rec. 2016. PMID: 27803375 Free PMC article.
It is recommended that trilostane therapy of canine hyperadrenocorticism is monitored using an ACTH stimulation test, however this has never been validated. ...Iatrogenic hypoadrenocorticism was not detected in any unwell dog. This study shows that the pre-trilostane …
It is recommended that trilostane therapy of canine hyperadrenocorticism is monitored using an ACTH stimulation test, however this ha …
Comparison of methods to monitor dogs with hypercortisolism treated with trilostane.
Golinelli S, de Marco V, Leal RO, Barbarossa A, Aniballi C, Maietti E, Tardo AM, Galac S, Fracassi F. Golinelli S, et al. J Vet Intern Med. 2021 Nov;35(6):2616-2627. doi: 10.1111/jvim.16269. Epub 2021 Oct 21. J Vet Intern Med. 2021. PMID: 34672018 Free PMC article.
BACKGROUND: The use of adrenocorticotropic hormone stimulation test as method to monitor efficacy of trilostane treatment of hypercortisolism (HC) in dogs has been questioned. OBJECTIVES: To evaluate and compare 12 methods with which to monitor efficacy of trilostane …
BACKGROUND: The use of adrenocorticotropic hormone stimulation test as method to monitor efficacy of trilostane treatment of hypercor …
Trilostane in dogs.
Ramsey IK. Ramsey IK. Vet Clin North Am Small Anim Pract. 2010 Mar;40(2):269-83. doi: 10.1016/j.cvsm.2009.10.008. Vet Clin North Am Small Anim Pract. 2010. PMID: 20219488
Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hyperadrenocorticism. Trilostane causes a significant but reversible decrease in cortisol production and a concomitant improvement in c …
Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hy …
Trilostane in advanced breast cancer.
Puddefoot JR, Barker S, Vinson GP. Puddefoot JR, et al. Expert Opin Pharmacother. 2006 Dec;7(17):2413-9. doi: 10.1517/14656566.7.17.2413. Expert Opin Pharmacother. 2006. PMID: 17109615 Review.
However, some patients acquire resistance to these treatments and, at present, further endocrine treatment is achieved by merely substituting the current medication with a different antiestrogen or aromatase inhibitor. Trilostane offers an alternative endocrine treatment d …
However, some patients acquire resistance to these treatments and, at present, further endocrine treatment is achieved by merely substitutin …
Management of hypoadrenocorticism (Addison's disease) in dogs.
Lathan P, Thompson AL. Lathan P, et al. Vet Med (Auckl). 2018 Feb 9;9:1-10. doi: 10.2147/VMRR.S125617. eCollection 2018. Vet Med (Auckl). 2018. PMID: 30050862 Free PMC article. Review.
The etiology may be immune-mediated destruction of the adrenal cortex, drug-induced adrenocortical necrosis (mitotane), enzyme inhibition (trilostane), or infiltrative processes such as neoplastic or fungal disease. ...
The etiology may be immune-mediated destruction of the adrenal cortex, drug-induced adrenocortical necrosis (mitotane), enzyme inhibition ( …
Trilostane (Modrenal).
[No authors listed] [No authors listed] Drug Ther Bull. 1982 Jan 22;20(2):7-8. Drug Ther Bull. 1982. PMID: 7067627 No abstract available.
Influence of medications on thyroid function in dogs: An update.
Bolton TA, Panciera DL. Bolton TA, et al. J Vet Intern Med. 2023 Sep-Oct;37(5):1626-1640. doi: 10.1111/jvim.16823. Epub 2023 Jul 27. J Vet Intern Med. 2023. PMID: 37498128 Free PMC article. Review.
Research since publication of the last review in the Journal of Veterinary Internal Medicine (JVIM) 20 years ago has evaluated the effects of amiodarone, zonisamide, inhalant anesthetics, clomipramine, trilostane, and toceranib on thyroid function tests in the dog. In addi …
Research since publication of the last review in the Journal of Veterinary Internal Medicine (JVIM) 20 years ago has evaluated the effects o …
Treating canine Cushing's syndrome: Current options and future prospects.
Sanders K, Kooistra HS, Galac S. Sanders K, et al. Vet J. 2018 Nov;241:42-51. doi: 10.1016/j.tvjl.2018.09.014. Epub 2018 Sep 27. Vet J. 2018. PMID: 30340659 Review.
Because these options are not without risks, not widely available and not suitable for every patient, pharmacotherapy is often used. In cases with PDH, the steroidogenesis inhibitor trilostane is most often used. In cases with an ACT, either trilostane or the adreno …
Because these options are not without risks, not widely available and not suitable for every patient, pharmacotherapy is often used. In case …
Antiepileptogenic effects of trilostane in the kainic acid model of temporal lobe epilepsy.
Costa AM, Gol M, Lucchi C, Biagini G. Costa AM, et al. Epilepsia. 2023 May;64(5):1376-1389. doi: 10.1111/epi.17561. Epub 2023 Mar 11. Epilepsia. 2023. PMID: 36861666
Notably, trilostane did not modify neuronal cell densities or the overall damage in the hippocampus. ...As expected, allopregnanolone and other neurosteroid levels were remarkably increased in the hippocampus and neocortex of rats treated for 6 days with trilostane, …
Notably, trilostane did not modify neuronal cell densities or the overall damage in the hippocampus. ...As expected, allopregnanolone …
513 results