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The complex metabolism of trimethylamine in humans: endogenous and exogenous sources.
Chhibber-Goel J, Gaur A, Singhal V, Parakh N, Bhargava B, Sharma A. Chhibber-Goel J, et al. Expert Rev Mol Med. 2016 Apr 29;18:e8. doi: 10.1017/erm.2016.6. Expert Rev Mol Med. 2016. PMID: 27126549 Review.
It is synthesised from dietary constituents, including choline, L-carnitine, betaine and lecithin by the action of microbial enzymes during both healthy and diseased conditions in humans. Trimethylaminuria (TMAU) is a disease typified by its association with the characteri …
It is synthesised from dietary constituents, including choline, L-carnitine, betaine and lecithin by the action of microbial enzymes during …
Mutation, polymorphism and perspectives for the future of human flavin-containing monooxygenase 3.
Zhou J, Shephard EA. Zhou J, et al. Mutat Res. 2006 Jun;612(3):165-171. doi: 10.1016/j.mrrev.2005.09.001. Epub 2006 Feb 14. Mutat Res. 2006. PMID: 16481213 Review.
Mutations in the FMO3 gene can result in defective trimethylamine (TMA) N-oxygenation, which gives rise to the disorder known as trimethylaminuria (TMAU) or "fish-odour syndrome". To date 18 mutations of FMO3 gene have been reported that cause TMAU, and polymorphic variant …
Mutations in the FMO3 gene can result in defective trimethylamine (TMA) N-oxygenation, which gives rise to the disorder known as trimethy …
Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism.
Cashman JR. Cashman JR. Pharmacogenomics. 2002 May;3(3):325-39. doi: 10.1517/14622416.3.3.325. Pharmacogenomics. 2002. PMID: 12052141 Review.
Deficient N-oxygenation of trimethylamine results in a condition called trimethylaminuria. Some treatment strategies for this inborn error of metabolism are discussed. ...
Deficient N-oxygenation of trimethylamine results in a condition called trimethylaminuria. Some treatment strategies for this inborn …
Antiretroviral treatment leading to secondary trimethylaminuria: Genetic associations and successful management with riboflavin.
Scimone C, Alibrandi S, Donato L, Giofrè SV, Rao G, Sidoti A, D'Angelo R. Scimone C, et al. J Clin Pharm Ther. 2021 Apr;46(2):304-309. doi: 10.1111/jcpt.13315. Epub 2020 Nov 28. J Clin Pharm Ther. 2021. PMID: 33247860
WHAT IS KNOWN AND OBJECTIVE: Trimethylaminuria is a metabolic disorder characterized by excessive excretion of trimethylamine in body fluids following FMO3 gene mutations. ...The present study reports antiretroviral treatment as risk factor for such secondary trimethyla …
WHAT IS KNOWN AND OBJECTIVE: Trimethylaminuria is a metabolic disorder characterized by excessive excretion of trimethylamine in body …
Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease.
Brugère JF, Borrel G, Gaci N, Tottey W, O'Toole PW, Malpuech-Brugère C. Brugère JF, et al. Gut Microbes. 2014 Jan-Feb;5(1):5-10. doi: 10.4161/gmic.26749. Epub 2013 Oct 31. Gut Microbes. 2014. PMID: 24247281 Free PMC article.
In individuals with a hereditary defect in flavin-containing monooxygenase 3, bacterial TMA production is believed to contribute to the symptoms of trimethylaminuria (TMAU; fish-odor syndrome). Intestinal microbiota TMA metabolism may also modulate atherosclerosis risk by …
In individuals with a hereditary defect in flavin-containing monooxygenase 3, bacterial TMA production is believed to contribute to the symp …
Novel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria.
Shimizu M, Yoda H, Igarashi N, Makino M, Tokuyama E, Yamazaki H. Shimizu M, et al. Xenobiotica. 2019 Oct;49(10):1244-1250. doi: 10.1080/00498254.2018.1539279. Epub 2018 Nov 29. Xenobiotica. 2019. PMID: 30351217 Clinical Trial.
Flavin-containing monooxygenase 3 (FMO3) in humans is polymorphic in several ethnic groups, including Caucasians, Africans and Asians. Some FMO3 variants are associated with a disorder trimethylaminuria. 2. In the current study, we used the results from urinary phenotyping …
Flavin-containing monooxygenase 3 (FMO3) in humans is polymorphic in several ethnic groups, including Caucasians, Africans and Asians. Some …
A spectrum of molecular variation in a cohort of Italian families with trimethylaminuria: identification of three novel mutations of the FM03 gene.
Teresa E, Lonardo F, Fiumara A, Lombardi C, Russo P, Zuppi C, Scarano G, Musumeci S, Gianfrancesco F. Teresa E, et al. Mol Genet Metab. 2006 Jun;88(2):192-5. doi: 10.1016/j.ymgme.2006.02.014. Epub 2006 Apr 4. Mol Genet Metab. 2006. PMID: 16600650
Fish-odor syndrome or trimethylaminuria, is a rare inborn error of metabolism inherited in an autosomal recessive fashion, involving the dysfunction of hepatic enzyme flavin-containing monooxygenase 3 (FMO3) that converts fishy-smelling trimethylamine (TMA) into odorless t …
Fish-odor syndrome or trimethylaminuria, is a rare inborn error of metabolism inherited in an autosomal recessive fashion, involving …
19 results