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Page 1
Flavin-containing monooxygenases: mutations, disease and drug response.
Phillips IR, Shephard EA. Phillips IR, et al. Trends Pharmacol Sci. 2008 Jun;29(6):294-301. doi: 10.1016/j.tips.2008.03.004. Epub 2008 Apr 16. Trends Pharmacol Sci. 2008. PMID: 18423897 Free article. Review.
But a substantial proportion of sub-Saharan Africans express functional FMO2 and, thus, are predicted to respond differently to drugs and other foreign chemicals....
But a substantial proportion of sub-Saharan Africans express functional FMO2 and, thus, are predicted to respond differently to drugs …
Fish odor syndrome.
Rehman HU. Rehman HU. Postgrad Med J. 1999 Aug;75(886):451-2. doi: 10.1136/pgmj.75.886.451. Postgrad Med J. 1999. PMID: 10646019 Free PMC article.
Recognition of the condition is important as dietary adjustments reduce the excretion of trimethylamine and may reduce the odour. Occasionally, a short course of metronidazole, neomycin and lactulose may suppress production of trimethylamine by reducing the activity of gut …
Recognition of the condition is important as dietary adjustments reduce the excretion of trimethylamine and may reduce the odour. Occasional …
Adaptive Modelling of Mutated FMO3 Enzyme Could Unveil Unexplored Scenarios Linking Variant Haplotypes to TMAU Phenotypes.
Alibrandi S, Nicita F, Donato L, Scimone C, Rinaldi C, D'Angelo R, Sidoti A. Alibrandi S, et al. Molecules. 2021 Nov 22;26(22):7045. doi: 10.3390/molecules26227045. Molecules. 2021. PMID: 34834137 Free PMC article.
Detected variants were, subsequently, deeply statistically and in silico characterized to determine their possible effects on the enzyme activity. To achieve this goal, a docking prediction for TMA/FMO3 and an unbinding pathway study were performed. ...CONCLUSIONS: Even if …
Detected variants were, subsequently, deeply statistically and in silico characterized to determine their possible effects on the enzyme act …
Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.
Bloom AJ, Murphy SE, Martinez M, von Weymarn LB, Bierut LJ, Goate A. Bloom AJ, et al. Pharmacogenet Genomics. 2013 Feb;23(2):62-8. doi: 10.1097/FPC.0b013e32835c3b48. Pharmacogenet Genomics. 2013. PMID: 23211429 Free PMC article.
RESULTS: FMO3 haplotype, based on all common coding variants in Europeans, significantly predicts nicotine metabolism and accounts for 2% of variance in the apparent percent of nicotine metabolized to cotinine. ...Cross-validation demonstrates calculated FMO3 haplotype par …
RESULTS: FMO3 haplotype, based on all common coding variants in Europeans, significantly predicts nicotine metabolism and accounts fo …
Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.
Shimizu M, Kobayashi Y, Hayashi S, Aoki Y, Yamazaki H. Shimizu M, et al. Mol Genet Metab. 2012 Nov;107(3):330-4. doi: 10.1016/j.ymgme.2012.06.014. Epub 2012 Jul 1. Mol Genet Metab. 2012. PMID: 22819296
In addition, single nucleotide substitutions p.Val58Ile, p.Pro70Leu, and p.Gly421Val in FMO3 were found in probands 3-7. In the course of DNA sequencing, another FMO3 variant, p.Thr488Ala, was found in two unrelated heterozygous subjects. ...
In addition, single nucleotide substitutions p.Val58Ile, p.Pro70Leu, and p.Gly421Val in FMO3 were found in probands 3-7. In the course …
Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome.
Dolphin CT, Janmohamed A, Smith RL, Shephard EA, Phillips IR. Dolphin CT, et al. Nat Genet. 1997 Dec;17(4):491-4. doi: 10.1038/ng1297-491. Nat Genet. 1997. PMID: 9398858
Although one of these represented a common polymorphism, the other, a C-->T transition in exon 4, was found only in an affected pedigree, in which it segregated with the disorder. The latter mutation predicts a proline-->leucine substitution at residue 153 and abolis …
Although one of these represented a common polymorphism, the other, a C-->T transition in exon 4, was found only in an affected pedigree, …
A novel mutation in the flavin-containing monooxygenase 3 gene (FMO3) of a Norwegian family causes trimethylaminuria.
Allerston CK, Vetti HH, Houge G, Phillips IR, Shephard EA. Allerston CK, et al. Mol Genet Metab. 2009 Sep-Oct;98(1-2):198-202. doi: 10.1016/j.ymgme.2009.06.002. Epub 2009 Jun 6. Mol Genet Metab. 2009. PMID: 19577495
Because the child is heterozygous for the R238Q mutation and no other mutation known to cause TMAuria was detected in her DNA she is predicted to suffer from transient childhood TMAuria, whereas her great-uncle has primary TMAuria....
Because the child is heterozygous for the R238Q mutation and no other mutation known to cause TMAuria was detected in her DNA she is pred …
Trimethylaminuria: fishy odors in children.
Lee CW, Yu JS, Turner BB, Murray KE. Lee CW, et al. N Engl J Med. 1976 Oct 21;295(17):937-8. doi: 10.1056/NEJM197610212951706. N Engl J Med. 1976. PMID: 987531 No abstract available.
13 results