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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1983 3
1984 2
1986 2
1987 6
1988 4
1989 3
1990 1
1991 6
1992 6
1993 6
1994 6
1995 6
1996 5
1997 5
1998 10
1999 11
2000 1
2001 2
2002 2
2003 5
2004 5
2005 5
2006 9
2007 6
2008 9
2009 9
2010 6
2011 7
2012 7
2013 10
2014 8
2015 8
2016 11
2017 11
2018 6
2019 2
2020 9
2021 3
2022 2
2023 3
2024 0

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209 results

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Page 1
Ibrutinib Treatment for First-Line and Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Analysis of the Pivotal Phase Ib/II PCYC-1102 Study.
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S. Byrd JC, et al. Clin Cancer Res. 2020 Aug 1;26(15):3918-3927. doi: 10.1158/1078-0432.CCR-19-2856. Epub 2020 Mar 24. Clin Cancer Res. 2020. PMID: 32209572 Free PMC article. Clinical Trial.
In relapsed/refractory CLL/SLL, median PFS was 52 months overall, 26 months in patients with chromosome 17p deletion, 51 months with 11q deletion, not reached with trisomy 12 or 13q deletion, and 88 months in patients without these cytogenetic abnormalities. ...CONC …
In relapsed/refractory CLL/SLL, median PFS was 52 months overall, 26 months in patients with chromosome 17p deletion, 51 months with 11q del …
Subgroup-specific gene expression profiles and mixed epistasis in chronic lymphocytic leukemia.
Lütge A, Lu J, Hüllein J, Walther T, Sellner L, Wu B, Rosenquist R, Oakes CC, Dietrich S, Huber W, Zenz T. Lütge A, et al. Haematologica. 2023 Oct 1;108(10):2664-2676. doi: 10.3324/haematol.2022.281869. Haematologica. 2023. PMID: 37226709 Free PMC article.
Unsupervised analysis revealed two major, orthogonal axes of gene expression variation: the first one represented the mutational status of the immunoglobulin heavy variable (IGHV) genes, and concomitantly, the three-group stratification of CLL by global DNA methylation. The secon …
Unsupervised analysis revealed two major, orthogonal axes of gene expression variation: the first one represented the mutational status of t …
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L. Sagatys EM, et al. Cancer Control. 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. Cancer Control. 2012. PMID: 22143059 Free article. Review.
The Rai and Binet clinical staging systems are used to define disease extent and predict survival. The pathology laboratory also provides important prognostic information. ...RESULTS: Novel biological and cytogenetic features such as immunoglobulin heavy-chain variable gen …
The Rai and Binet clinical staging systems are used to define disease extent and predict survival. The pathology laboratory also prov …
Biomarkers in chronic lymphocytic leukemia: Clinical applications and prognostic markers.
Amaya-Chanaga CI, Rassenti LZ. Amaya-Chanaga CI, et al. Best Pract Res Clin Haematol. 2016 Mar;29(1):79-89. doi: 10.1016/j.beha.2016.08.005. Epub 2016 Aug 10. Best Pract Res Clin Haematol. 2016. PMID: 27742074 Review.
Prognostic factors such as chromosome abnormalities (trisomy 12, 11q deletions and 17p deletions), beta2 microglobulin, thymidine kinase, CD38 and ZAP-70 expression, IGHV mutation status, and mutations in genes such as NOTCH1, MYD88, SF3B1, and ATM are also predi …
Prognostic factors such as chromosome abnormalities (trisomy 12, 11q deletions and 17p deletions), beta2 microglobulin, thymid …
Morphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review.
Autore F, Strati P, Laurenti L, Ferrajoli A. Autore F, et al. Haematologica. 2018 Jun;103(6):931-938. doi: 10.3324/haematol.2017.186684. Epub 2018 May 10. Haematologica. 2018. PMID: 29748447 Free PMC article. Review.
Chronic lymphocytic leukemia is an extremely heterogeneous disease and prognostic factors such as chromosomal abnormalities are important predictors of time to first treatment and survival. Trisomy 12 is the second most frequent aberration detected by fluores …
Chronic lymphocytic leukemia is an extremely heterogeneous disease and prognostic factors such as chromosomal abnormalities are important …
The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatment.
Gaidano G, Rossi D. Gaidano G, et al. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):329-337. doi: 10.1182/asheducation-2017.1.329. Hematology Am Soc Hematol Educ Program. 2017. PMID: 29222275 Free PMC article. Review.
Approximately 80% of CLL patients carry at least 1 of 4 common chromosomal alterations, namely deletion 13q14, deletion 11q22-23, deletion 17p12, and trisomy 12. Knowledge of the CLL genome has translated into the availability of molecular biomarkers for prognosis a …
Approximately 80% of CLL patients carry at least 1 of 4 common chromosomal alterations, namely deletion 13q14, deletion 11q22-23, deletion 1 …
Genetics and risk-stratified approach to therapy in chronic lymphocytic leukemia.
Zenz T, Döhner H, Stilgenbauer S. Zenz T, et al. Best Pract Res Clin Haematol. 2007 Sep;20(3):439-53. doi: 10.1016/j.beha.2007.02.006. Best Pract Res Clin Haematol. 2007. PMID: 17707832 Review.
In recent years molecular and cellular markers have helped to predict the prognosis of patients with CLL. Ig V(H) status and genomic aberrations subdivide CLL into distinct clinical subgroups. ...The most frequent aberrations are deletions in 13q, 11q, or 17p, and triso …
In recent years molecular and cellular markers have helped to predict the prognosis of patients with CLL. Ig V(H) status and genomic …
The concept of typical and atypical chronic lymphocytic leukaemia.
Criel A, Michaux L, De Wolf-Peeters C. Criel A, et al. Leuk Lymphoma. 1999 Mar;33(1-2):33-45. doi: 10.3109/10428199909093723. Leuk Lymphoma. 1999. PMID: 10194119 Review.
In recent years, however, a strong correlation was found between atypical morphology trisomy 12 and an aberrant immunophenotype. In the first part of this review we discuss current concepts and generally accepted data on morphology, immunophenotype, genetic abnormal …
In recent years, however, a strong correlation was found between atypical morphology trisomy 12 and an aberrant immunophenotyp …
Cytogenetic studies in patients with Richter's syndrome.
Hébert J, Jonveaux P, d'Agay MF, Berger R. Hébert J, et al. Cancer Genet Cytogenet. 1994 Mar;73(1):65-8. doi: 10.1016/0165-4608(94)90184-8. Cancer Genet Cytogenet. 1994. PMID: 8174077 Review.
Chromosomes 14 and 11 were the most frequently involved. Neither deletion of 13q14 nor complete trisomy 12 was observed. Two patients had structural rearrangement of 12q with t(5;12)(q21-q22;q23-q24). ...
Chromosomes 14 and 11 were the most frequently involved. Neither deletion of 13q14 nor complete trisomy 12 was observed …
Morphological and immunophenotypic features of chronic lymphocytic leukemia.
Matutes E, Polliack A. Matutes E, et al. Rev Clin Exp Hematol. 2000 Mar;4(1):22-47. doi: 10.1046/j.1468-0734.2000.00002.x. Rev Clin Exp Hematol. 2000. PMID: 11486329 Review.
There is strong evidence of a close association between atypical morphology (CLL/PL) and atypical (CLL) and clinical features, e.g. disease progression, advanced stage and survival, molecular genetics, particularly trisomy 12, but also the rare cases with t(11;14) o …
There is strong evidence of a close association between atypical morphology (CLL/PL) and atypical (CLL) and clinical features, e.g. disease …
209 results