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Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P. Adsay V, et al. Am J Surg Pathol. 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. Am J Surg Pathol. 2012. PMID: 22895264
Intracholecystic papillary-tubular neoplasms are relatively indolent neoplasia with significantly better prognosis compared with pancreatobiliary-type GB carcinomas. In contrast, even seemingly innocuous examples such as those referred to as "pyloric gland adenomas" can pr …
Intracholecystic papillary-tubular neoplasms are relatively indolent neoplasia with significantly better prognosis compared with panc …
The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D. Abdelal H, et al. Surg Pathol Clin. 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. Surg Pathol Clin. 2022. PMID: 36049837 Review.
Invasive carcinoma arising from intracholecystic papillary-tubular neoplasm have a better prognosis than de novo gallbladder carcinomas. The pathology of intracholecystic papillary-tubular neoplasm, including the challenges involved in the diagnosis of this entity, is disc …
Invasive carcinoma arising from intracholecystic papillary-tubular neoplasm have a better prognosis than de novo gallbladder carcinom …
Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K. Zulfiqar M, et al. Radiographics. 2022 Sep-Oct;42(5):1320-1337. doi: 10.1148/rg.210194. Epub 2022 Aug 5. Radiographics. 2022. PMID: 35930475 Review.
Biliary-type adenocarcinoma constitutes the most common histologic type of ampullary and gallbladder malignancies. Its prognosis is poor and surgical resection is considered curative, so early detection is key, with multimodality imaging playing a central role in making th …
Biliary-type adenocarcinoma constitutes the most common histologic type of ampullary and gallbladder malignancies. Its prognosis is p …
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD. Xue Y, et al. Surg Pathol Clin. 2020 Sep;13(3):453-467. doi: 10.1016/j.path.2020.05.005. Epub 2020 Jul 15. Surg Pathol Clin. 2020. PMID: 32773194 Review.
Ampullary cancer can also be subclassified based on immunohistochemical features, however these classification systems fail to show robust prognostic reliability. More recently, the molecular landscape of AC has been uncovered, and has been shown to have prognostic
Ampullary cancer can also be subclassified based on immunohistochemical features, however these classification systems fail to show robust …
Intra-Ampullary Papillary-Tubular Neoplasm: A Population-Based Analysis.
Ren D, Li D, Jin X, Meng Z, Wu H. Ren D, et al. Med Sci Monit. 2019 Sep 30;25:7332-7341. doi: 10.12659/MSM.916411. Med Sci Monit. 2019. PMID: 31564715 Free PMC article.
CONCLUSIONS Analysis of the SEER database clearly demonstrated that IAPN was a precancerous lesion tend to be diagnosed earlier compared with OBIPMN, which contributed to the better prognosis, and surgery was suggested if possible....
CONCLUSIONS Analysis of the SEER database clearly demonstrated that IAPN was a precancerous lesion tend to be diagnosed earlier compared wit …
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D. Argon A, et al. Int J Surg Pathol. 2016 Sep;24(6):504-11. doi: 10.1177/1066896916644781. Epub 2016 Apr 27. Int J Surg Pathol. 2016. PMID: 27122163
However, there are not enough data concerning the features of large lesions with high-grade dysplasia and their prognoses. Our data suggest that cases with diffuse high-grade dysplasia and tubulopapillary/papillary growth pattern, large tumor size, and high Ki67 proliferat …
However, there are not enough data concerning the features of large lesions with high-grade dysplasia and their prognoses. Our data s …
Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern.
Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M. Tsukahara T, et al. Mod Pathol. 2016 Mar;29(3):293-301. doi: 10.1038/modpathol.2015.152. Epub 2016 Jan 15. Mod Pathol. 2016. PMID: 26769137 Free article.
Intraductal neoplasms of the bile duct are macroscopically characterized by exophytic or polypoid growth patterns and have a favorable prognosis. Although some tumors with a predominantly tubular microscopic pattern have been reported, they have not been well characterized …
Intraductal neoplasms of the bile duct are macroscopically characterized by exophytic or polypoid growth patterns and have a favorable pr
Prognostic Impact of Intra-Ampullary Papillary-Tubular Neoplasm versus Flat Dysplasia as Precursor Lesions of Ampullary Adenocarcinoma.
Han S, Jang KT, Choi DW, Choi SH, Heo JS, Han IW, Park D, Ryu Y. Han S, et al. Dig Surg. 2020;37(6):505-514. doi: 10.1159/000510961. Epub 2020 Oct 20. Dig Surg. 2020. PMID: 33080609
BACKGROUND: The aim of this study is to compare the prognostic impact of 2 precursor lesions of ampullary adenocarcinoma, intra-ampullary papillary-tubular neoplasm (IAPN) and flat dysplasia (FD). ...On multivariate analysis, higher levels of tumor markers including CEA an …
BACKGROUND: The aim of this study is to compare the prognostic impact of 2 precursor lesions of ampullary adenocarcinoma, intra-ampul …
Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice.
Nagao M, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Taketo MM, Ferrer J, Tsuruyama T, Nakanuma Y, Taura K, Uemoto S, Seno H. Nagao M, et al. Cancer Res. 2022 May 3;82(9):1803-1817. doi: 10.1158/0008-5472.CAN-21-2176. Cancer Res. 2022. PMID: 35247892
Biliary cancer has long been known to carry a poor prognosis, yet the molecular pathogenesis of carcinoma of the extrahepatic biliary system and its precursor lesions remains elusive. ...
Biliary cancer has long been known to carry a poor prognosis, yet the molecular pathogenesis of carcinoma of the extrahepatic biliary …
Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst: a link between choledochal cyst and gallbladder cancer?
Michalinos A, Alexandrou P, Papalambros A, Oikonomou D, Sakellariou S, Baliou E, Alexandrou A, Schizas D, Felekouras E. Michalinos A, et al. World J Surg Oncol. 2016 Aug 2;14(1):202. doi: 10.1186/s12957-016-0962-x. World J Surg Oncol. 2016. PMID: 27480698 Free PMC article.
In contrast with the commoner flat-type precursor gallbladder cancer lesions, they follow a more indolent clinical course and probably different genetic pathways to carcinogenesis. ...The patient underwent excision of the extrahepatic biliary tree for a Todani I choledocha …
In contrast with the commoner flat-type precursor gallbladder cancer lesions, they follow a more indolent clinical course and probabl …
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