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Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response.
Chanan-Khan A, Miller KC, Lawrence D, Padmanabhan S, Miller A, Hernandez-Illatazurri F, Czuczman MS, Wallace PK, Zeldis JB, Lee K. Chanan-Khan A, et al. Cancer. 2011 May 15;117(10):2127-35. doi: 10.1002/cncr.25748. Epub 2010 Nov 29. Cancer. 2011. PMID: 21523725 Free article. Clinical Trial.
BACKGROUND: In patients with chronic lymphocytic leukemia (CLL), treatment with lenalidomide induces a unique, previously uncharacterized, immune response called tumor flare reaction (TFR). The clinical significance of this reaction remains unknown. ...
BACKGROUND: In patients with chronic lymphocytic leukemia (CLL), treatment with lenalidomide induces a unique, previously uncharacterized, i …
Myocarditis during lenalidomide therapy.
Carver JR, Nasta S, Chong EA, Stonecypher M, Wheeler JE, Ahmadi T, Schuster SJ. Carver JR, et al. Ann Pharmacother. 2010 Nov;44(11):1840-3. doi: 10.1345/aph.1P044. Epub 2010 Sep 28. Ann Pharmacother. 2010. PMID: 20876827
Common toxicities are myelosuppression, fatigue, diarrhea, skin rash, venous thromboembolism, peripheral neuropathy, and tumor flare reaction. Cardiovascular toxicity has been limited to atrial fibrillation and an increased risk for venous thromboembolism. .. …
Common toxicities are myelosuppression, fatigue, diarrhea, skin rash, venous thromboembolism, peripheral neuropathy, and tumor fla …
Sequential ofatumumab and lenalidomide for the treatment of relapsed and refractory chronic lymphocytic leukemia and small lymphocytic lymphoma.
Costa LJ, Fanning SR, Stephenson J Jr, Afrin LB, Kistner-Griffin E, Bentz TA, Stuart RK. Costa LJ, et al. Leuk Lymphoma. 2015 Mar;56(3):645-9. doi: 10.3109/10428194.2014.935369. Leuk Lymphoma. 2015. PMID: 25130476 Clinical Trial.
Neutropenia and thrombocytopenia were the most frequent adverse events. Tumor flare reaction occurred in 43% of subjects. Intracycle sequential ofatumumab plus lenalidomide is active in high-risk R/R CLL and well tolerated except for frequent cytopenias....
Neutropenia and thrombocytopenia were the most frequent adverse events. Tumor flare reaction occurred in 43% of subject …
Similar frequency of testosterone surge after repeat injections of goserelin (Zoladex) 3.6 mg and 10.8 mg: results of a randomized open-label trial.
Zinner NR, Bidair M, Centeno A, Tomera K. Zinner NR, et al. Urology. 2004 Dec;64(6):1177-81. doi: 10.1016/j.urology.2004.07.033. Urology. 2004. PMID: 15596193 Clinical Trial.
No patient with a testosterone surge had clinical symptoms of a tumor flare reaction. CONCLUSIONS: The testosterone levels were consistently maintained within the castrate range (18.5 ng/dL or less) in most (77.4%) patients receiving long-term 3.6 mg or 10.8 …
No patient with a testosterone surge had clinical symptoms of a tumor flare reaction. CONCLUSIONS: The testosterone lev …