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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1978 1
1979 1
1980 1
1981 2
1982 1
1984 1
1985 1
1986 1
1987 2
1989 1
1990 1
1992 1
1994 2
1995 3
1996 1
1998 3
1999 1
2000 3
2001 1
2002 5
2003 1
2004 7
2005 10
2006 11
2007 12
2008 13
2009 10
2010 13
2011 12
2012 18
2013 22
2014 23
2015 29
2016 27
2017 33
2018 45
2019 58
2020 87
2021 106
2022 122
2023 151
2024 58

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830 results

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Page 1
A pan-cancer single-cell panorama of human natural killer cells.
Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L, Peng H, Wang D, Zhang Z. Tang F, et al. Cell. 2023 Sep 14;186(19):4235-4251.e20. doi: 10.1016/j.cell.2023.07.034. Epub 2023 Aug 21. Cell. 2023. PMID: 37607536 Free article.
Specific myeloid cell subpopulations, in particular LAMP3(+) dendritic cells, appear to mediate the regulation of NK cell anti-tumor immunity. Our study provides insights into NK-cell-based cancer immunity and highlights potential clinical utilities of NK cell subse …
Specific myeloid cell subpopulations, in particular LAMP3(+) dendritic cells, appear to mediate the regulation of NK cell anti-tumor …
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC. Ringel AE, et al. Cell. 2020 Dec 23;183(7):1848-1866.e26. doi: 10.1016/j.cell.2020.11.009. Epub 2020 Dec 9. Cell. 2020. PMID: 33301708 Free PMC article.
Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we demonstrate that high-fat diet (HFD)-induced obesity impairs CD8(+) T cell function i …
Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti- …
Cancer-associated adipocytes: key players in breast cancer progression.
Wu Q, Li B, Li Z, Li J, Sun S, Sun S. Wu Q, et al. J Hematol Oncol. 2019 Sep 10;12(1):95. doi: 10.1186/s13045-019-0778-6. J Hematol Oncol. 2019. PMID: 31500658 Free PMC article. Review.
We envisage that besides having a direct impact on tumor cells, CAAs systemically preconditions the tumor microenvironment by favoring anti-tumor immunity. A better understanding of cancer-associated adipocytes and the key molecular events in the adipocyte-cancer ce …
We envisage that besides having a direct impact on tumor cells, CAAs systemically preconditions the tumor microenvironment by favoring anti- …
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion.
Fang W, Zhou T, Shi H, Yao M, Zhang D, Qian H, Zeng Q, Wang Y, Jin F, Chai C, Chen T. Fang W, et al. J Exp Clin Cancer Res. 2021 Jan 4;40(1):4. doi: 10.1186/s13046-020-01786-6. J Exp Clin Cancer Res. 2021. PMID: 33390170 Free PMC article.
BACKGROUND: Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molec …
BACKGROUND: Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor …
CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis.
Lerner EC, Woroniecka KI, D'Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, Waibl-Polania J, Wachsmuth LP, Miggelbrink AM, Jackson JD, Cui X, Raj JA, Tomaszewski WH, Cook SL, Sampson JH, Patel AP, Khasraw M, Gunn MD, Fecci PE. Lerner EC, et al. Nat Cancer. 2023 Sep;4(9):1258-1272. doi: 10.1038/s43018-023-00600-4. Epub 2023 Aug 3. Nat Cancer. 2023. PMID: 37537301 Free PMC article.
The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell killing by CD8(+) T cells recognizing cognate antigens presented in the context of target cell major histocompatibility complex (MHC) class I (MHC-I) molecules. ...These studies c …
The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell killing by CD8(+) T cells recognizing c …
CAR γδ T cells for cancer immunotherapy. Is the field more yellow than green?
Ganapathy T, Radhakrishnan R, Sakshi S, Martin S. Ganapathy T, et al. Cancer Immunol Immunother. 2023 Feb;72(2):277-286. doi: 10.1007/s00262-022-03260-y. Epub 2022 Aug 12. Cancer Immunol Immunother. 2023. PMID: 35960333 Free PMC article. Review.
The HLA independent, multivalent, versatile and systemic anti-tumor immunity increases the desirability of gammadelta T cells as an alternate chassis for CAR. ...
The HLA independent, multivalent, versatile and systemic anti-tumor immunity increases the desirability of gammadelta T cells …
Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity.
Liu L, Li S, Qu Y, Bai H, Pan X, Wang J, Wang Z, Duan J, Zhong J, Wan R, Fei K, Xu J, Yuan L, Wang C, Xue P, Zhang X, Ma Z, Wang J. Liu L, et al. Cell Rep Med. 2023 Oct 17;4(10):101206. doi: 10.1016/j.xcrm.2023.101206. Epub 2023 Sep 27. Cell Rep Med. 2023. PMID: 37769655 Free PMC article.
Mechanistically, ERO1A ablation impairs the balance between IRE1alpha and PERK signaling activities and induces lethal unfolded protein responses in tumor cells undergoing endoplasmic reticulum stress, thereby enhancing anti-tumor immunity via immunogenic cell death …
Mechanistically, ERO1A ablation impairs the balance between IRE1alpha and PERK signaling activities and induces lethal unfolded protein resp …
Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma.
Calderaro J, Petitprez F, Becht E, Laurent A, Hirsch TZ, Rousseau B, Luciani A, Amaddeo G, Derman J, Charpy C, Zucman-Rossi J, Fridman WH, Sautès-Fridman C. Calderaro J, et al. J Hepatol. 2019 Jan;70(1):58-65. doi: 10.1016/j.jhep.2018.09.003. Epub 2018 Sep 11. J Hepatol. 2019. PMID: 30213589
Thus, intra-tumoral TLSs may reflect the existence of ongoing, effective anti-tumor immunity. LAY SUMMARY: Tertiary lymphoid structures provide a critical microenvironment for generating anti-tumor immune responses, and are associated with improved clinical outcome …
Thus, intra-tumoral TLSs may reflect the existence of ongoing, effective anti-tumor immunity. LAY SUMMARY: Tertiary lymphoid s …
830 results