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116 results

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Page 1
Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome).
Strassburg CP. Strassburg CP. Best Pract Res Clin Gastroenterol. 2010 Oct;24(5):555-71. doi: 10.1016/j.bpg.2010.07.007. Best Pract Res Clin Gastroenterol. 2010. PMID: 20955959 Review.
Hyperbilirubinemia is an important clinical sign that often indicates severe hepatobiliary disease of different etiologies. ...Dubin-Johnson and Rotor syndromes are rare, exhibit mixed direct and indirect hyperbilirubinemia as well as typical profiles or urinary coproporph …
Hyperbilirubinemia is an important clinical sign that often indicates severe hepatobiliary disease of different etiologies. ...Dubin- …
Gene Therapy in Patients with the Crigler-Najjar Syndrome.
D'Antiga L, Beuers U, Ronzitti G, Brunetti-Pierri N, Baumann U, Di Giorgio A, Aronson S, Hubert A, Romano R, Junge N, Bosma P, Bortolussi G, Muro AF, Soumoudronga RF, Veron P, Collaud F, Knuchel-Legendre N, Labrune P, Mingozzi F. D'Antiga L, et al. N Engl J Med. 2023 Aug 17;389(7):620-631. doi: 10.1056/NEJMoa2214084. N Engl J Med. 2023. PMID: 37585628 Clinical Trial.
BACKGROUND: Patients with the Crigler-Najjar syndrome lack the enzyme uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the absence of which leads to severe unconjugated hyperbilirubinemia that can cause irreversible neurologic injury and death. ...
BACKGROUND: Patients with the Crigler-Najjar syndrome lack the enzyme uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the …
Pharmacological therapies for unconjugated hyperbilirubinemia.
Cuperus FJ, Hafkamp AM, Hulzebos CV, Verkade HJ. Cuperus FJ, et al. Curr Pharm Des. 2009;15(25):2927-38. doi: 10.2174/138161209789058219. Curr Pharm Des. 2009. PMID: 19754369 Review.
Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion. ...
Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for s …
Clofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review.
Xiong T, Chen D, Duan Z, Qu Y, Mu D. Xiong T, et al. Indian Pediatr. 2012 Jan;49(1):35-41. doi: 10.1007/s13312-012-0012-x. Indian Pediatr. 2012. PMID: 22318100 Free article. Review.
OBJECTIVE: To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. METHODS: A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibr …
OBJECTIVE: To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. METHODS: A systematic review …
Breastfeeding and jaundice.
Gartner LM. Gartner LM. J Perinatol. 2001 Dec;21 Suppl 1:S25-9; discussion S35-9. doi: 10.1038/sj.jp.7210629. J Perinatol. 2001. PMID: 11803412
In the breastfed infant, prolongation of unconjugated hyperbilirubinemia into the third and later weeks of life in the healthy newborn is a normal and regularly occurring extension of physiologic jaundice. ...
In the breastfed infant, prolongation of unconjugated hyperbilirubinemia into the third and later weeks of life in the healthy …
Atazanavir-induced unconjugated hyperbilirubinemia prevents vascular hyporeactivity during experimental human endotoxemia.
Dorresteijn MJ, Dekker D, Zwaag J, Heemskerk S, Roelofs HMJ, Smits P, van der Hoeven JG, Wagener FADTG, Pickkers P. Dorresteijn MJ, et al. Front Immunol. 2023 May 16;14:1176775. doi: 10.3389/fimmu.2023.1176775. eCollection 2023. Front Immunol. 2023. PMID: 37261364 Free PMC article.
In the present study, we investigated the impact of atazanavir-induced (unconjugated) hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. ...CONCLUSIONS: Atazanavir-induced hyperbilirubinemia increase …
In the present study, we investigated the impact of atazanavir-induced (unconjugated) hyperbilirubinemia on antioxidant capaci …
Towards liver-directed gene therapy for Crigler-Najjar syndrome.
Miranda PS, Bosma PJ. Miranda PS, et al. Curr Gene Ther. 2009 Apr;9(2):72-82. doi: 10.2174/156652309787909508. Curr Gene Ther. 2009. PMID: 19355865 Review.
This hepatic enzyme catalyzes the glucuronidation of bilirubin, an essential step in excretion into bile of this neurotoxic compound. As a result, CN patients suffer from severe unconjugated hyperbilirubinemia and are at risk of bilirubin encephalopathy. ...Several …
This hepatic enzyme catalyzes the glucuronidation of bilirubin, an essential step in excretion into bile of this neurotoxic compound. As a r …
Bilirubin-albumin binding, bilirubin/albumin ratios, and free bilirubin levels: where do we stand?
Hulzebos CV, Dijk PH. Hulzebos CV, et al. Semin Perinatol. 2014 Nov;38(7):412-21. doi: 10.1053/j.semperi.2014.08.004. Epub 2014 Oct 7. Semin Perinatol. 2014. PMID: 25304058 Review.
Treatment for unconjugated hyperbilirubinemia is predominantly based on one parameter, i.e., total serum bilirubin (TSB) levels. ...Methods to measure bilirubin-albumin binding or UCBfree are neither routinely performed in Western clinical laboratories nor in …
Treatment for unconjugated hyperbilirubinemia is predominantly based on one parameter, i.e., total serum bilirubin (TSB) level …
Antiretroviral and anti-hepatitis C virus direct-acting antiviral-related hepatotoxicity.
Han H, Agarwal R, Martel-Laferriere V, Dieterich DT. Han H, et al. Clin Liver Dis. 2013 Nov;17(4):657-70, ix. doi: 10.1016/j.cld.2013.07.007. Epub 2013 Sep 4. Clin Liver Dis. 2013. PMID: 24099023 Review.
Antiretroviral-related hepatotoxicity occurs commonly in patients with human immunodeficiency virus (HIV). Liver injury ranges from unconjugated hyperbilirubinemia and nodular regenerative hyperplasia to lactic acidosis and toxic hepatitis. ...
Antiretroviral-related hepatotoxicity occurs commonly in patients with human immunodeficiency virus (HIV). Liver injury ranges from uncon …
Is neonatal jaundice associated with Autism Spectrum Disorders: a systematic review.
Amin SB, Smith T, Wang H. Amin SB, et al. J Autism Dev Disord. 2011 Nov;41(11):1455-63. doi: 10.1007/s10803-010-1169-6. J Autism Dev Disord. 2011. PMID: 22009628 Free PMC article. Review.
Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal jaundice (unconjugated hyperbilirubinemia) and Autism Spectrum Disorder (ASD) in term and preterm infants. ...Overall, jaundic …
Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal …
116 results