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Quoted phrase not found in phrase index: "Urine xenobiotic"
Page 1
Toxico-/biokinetics of nanomaterials.
Landsiedel R, Fabian E, Ma-Hock L, van Ravenzwaay B, Wohlleben W, Wiench K, Oesch F. Landsiedel R, et al. Arch Toxicol. 2012 Jul;86(7):1021-60. doi: 10.1007/s00204-012-0858-7. Epub 2012 May 11. Arch Toxicol. 2012. PMID: 22576463 Review.
In most studies with topical skin application, unintentional permeation and systemic availability were not observed; permeation for some NM with distinct properties was observed in animals. ...NM reaching the GI tract are excreted with the feces, but of some NM low …
In most studies with topical skin application, unintentional permeation and systemic availability were not observed; permeation for s …
Xenobiotic Conjugation with Dicarboxylic Acids.
Mitchell SC, Steventon GB. Mitchell SC, et al. Curr Drug Metab. 2018;19(13):1130-1137. doi: 10.2174/1389200219666180803142233. Curr Drug Metab. 2018. PMID: 30073923 Review.
BACKGROUND: Although it is believed widely that the various routes of xenobiotic metabolism are now all known and effectively understood, occasionally there emerges a metabolite that signals a novel biotransformation pathway, especially where the xenobiotic may in s …
BACKGROUND: Although it is believed widely that the various routes of xenobiotic metabolism are now all known and effectively underst …
Toxicology of decamethylcyclopentasiloxane (D5).
Dekant W, Klaunig JE. Dekant W, et al. Regul Toxicol Pharmacol. 2016 Feb;74 Suppl:S67-76. doi: 10.1016/j.yrtph.2015.06.011. Epub 2015 Jun 22. Regul Toxicol Pharmacol. 2016. PMID: 26111607 Free article. Review.
Following inhalation exposure, exhalation of unchanged D5 and excretion of metabolites with urine are major pathways for clearance in mammals. Due to this rapid clearance by exhalation, the potential for bioaccumulation of D5 is considered unlikely. ...In repeated studies …
Following inhalation exposure, exhalation of unchanged D5 and excretion of metabolites with urine are major pathways for clearance in …
Is It Realistic to Propose Determination of a Lifetime Internal Exposome?
Sabbioni G, Berset JD, Day BW. Sabbioni G, et al. Chem Res Toxicol. 2020 Aug 17;33(8):2010-2021. doi: 10.1021/acs.chemrestox.0c00092. Epub 2020 Jul 16. Chem Res Toxicol. 2020. PMID: 32672951 Review.
Biomonitoring of xenobiotics has been performed for many years in occupational and environmental medicine. ...It is likely that only a small fraction of xenobiotics form such adducts. In addition, adduct analyses are more work intensive than the measurement of xe …
Biomonitoring of xenobiotics has been performed for many years in occupational and environmental medicine. ...It is likely that only …
Advances in drug metabolism and pharmacogenetics research in Australia.
Mackenzie PI, Somogyi AA, Miners JO. Mackenzie PI, et al. Pharmacol Res. 2017 Feb;116:7-19. doi: 10.1016/j.phrs.2016.12.008. Epub 2016 Dec 9. Pharmacol Res. 2017. PMID: 27956261 Review.
Metabolism facilitates the elimination, detoxification and excretion in urine or bile (as biotransformation products) of a myriad of structurally diverse drugs and other chemicals. The metabolism of drugs, non-drug xenobiotics and many endogenous compounds is cataly …
Metabolism facilitates the elimination, detoxification and excretion in urine or bile (as biotransformation products) of a myriad of …
Drug toxicity in the proximal tubule: new models, methods and mechanisms.
Hall AM, Trepiccione F, Unwin RJ. Hall AM, et al. Pediatr Nephrol. 2022 May;37(5):973-982. doi: 10.1007/s00467-021-05121-9. Epub 2021 May 28. Pediatr Nephrol. 2022. PMID: 34050397 Free PMC article. Review.
The proximal tubule (PT) reabsorbs most of the glomerular filtrate and plays an important role in the uptake, metabolism and excretion of xenobiotics. Some therapeutic drugs are harmful to the PT, and resulting nephrotoxicity is thought to be responsible for approximately …
The proximal tubule (PT) reabsorbs most of the glomerular filtrate and plays an important role in the uptake, metabolism and excretion of …
The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance.
Koren G. Koren G. Med Toxicol Adverse Drug Exp. 1989 Jan-Feb;4(1):59-72. doi: 10.1007/BF03259903. Med Toxicol Adverse Drug Exp. 1989. PMID: 2651851 Review.
Scores of drugs in common clinical use are capable of inflicting various degrees of damage to the kidney. ...Several drugs including d-penicillamine, thiopronine, captopril, pyrithioxine and methimazole, are believed to exert their damage through their sulfhydryl group whi …
Scores of drugs in common clinical use are capable of inflicting various degrees of damage to the kidney. ...Several drugs including …
Species differences in N-glucuronidation.
Chiu SH, Huskey SW. Chiu SH, et al. Drug Metab Dispos. 1998 Sep;26(9):838-47. Drug Metab Dispos. 1998. PMID: 9733661 Review.
For tertiary amines, most notably the tricyclic antidepressant and antihistamine drugs, N-glucuronidation is commonly observed in non-human primates and man. There are examples, however, of quaternary glucuronidation occurring in lower animal species. In exploring species …
For tertiary amines, most notably the tricyclic antidepressant and antihistamine drugs, N-glucuronidation is commonly observed in non …
Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds - Implications for Health.
Borowska S, Brzoska MM, Tomczyk M. Borowska S, et al. Curr Drug Targets. 2018;19(14):1612-1638. doi: 10.2174/1389450119666180403101555. Curr Drug Targets. 2018. PMID: 29611487 Review.
Nowadays, growing interest in the possibility of prophylactic and therapeutic use of plant products rich in biologically active compounds has been observed. Among them, special interest has been focused on polyphenol-rich products. ...Moreover, data from studies in animal …
Nowadays, growing interest in the possibility of prophylactic and therapeutic use of plant products rich in biologically active compounds ha …
Beta-Glucuronidase Activity: Another Source of Ethyl Glucuronide.
Müller A, Aboutara N, Jungen H, Szewczyk A, Piesch M, Iwersen-Bergmann S. Müller A, et al. J Anal Toxicol. 2023 Mar 21;47(2):114-120. doi: 10.1093/jat/bkac038. J Anal Toxicol. 2023. PMID: 35713221
Numerous classes of endogenous and xenobiotic compounds are conjugated to uridine-5'-diphospho (UDP)-alpha-D-glucuronic acid which is catalyzed by human UDP-Glucuronosyltransferases (UGTs). ...EtG post post-collection synthesis in E.coli coli-contaminated urine samp …
Numerous classes of endogenous and xenobiotic compounds are conjugated to uridine-5'-diphospho (UDP)-alpha-D-glucuronic acid which is …
164 results