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694 results

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Page 1
The Warburg Effect: How Does it Benefit Cancer Cells?
Liberti MV, Locasale JW. Liberti MV, et al. Trends Biochem Sci. 2016 Mar;41(3):211-218. doi: 10.1016/j.tibs.2015.12.001. Epub 2016 Jan 5. Trends Biochem Sci. 2016. PMID: 26778478 Free PMC article. Review.
The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate. This phenomenon is observed even in the presence of completely functioning mitochondria and, together, is known as the 'Warburg Effect'. ...D …
The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate. This phenomenon is …
Glucose Metabolism in Cancer.
Bose S, Le A. Bose S, et al. Adv Exp Med Biol. 2018;1063:3-12. doi: 10.1007/978-3-319-77736-8_1. Adv Exp Med Biol. 2018. PMID: 29946772 Review.
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warbur …
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his …
Otto Warburg's contributions to current concepts of cancer metabolism.
Koppenol WH, Bounds PL, Dang CV. Koppenol WH, et al. Nat Rev Cancer. 2011 May;11(5):325-37. doi: 10.1038/nrc3038. Epub 2011 Apr 14. Nat Rev Cancer. 2011. PMID: 21508971 Review.
Warburg and co-workers showed in the 1920s that, under aerobic conditions, tumour tissues metabolize approximately tenfold more glucose to lactate in a given time than normal tissues, a phenomenon known as the Warburg effect. However, this increase in aerobic glycol …
Warburg and co-workers showed in the 1920s that, under aerobic conditions, tumour tissues metabolize approximately tenfold more glucose to l …
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.
Li Z, Zhang H. Li Z, et al. Cell Mol Life Sci. 2016 Jan;73(2):377-92. doi: 10.1007/s00018-015-2070-4. Epub 2015 Oct 23. Cell Mol Life Sci. 2016. PMID: 26499846 Free PMC article. Review.
Metabolic reprogramming is widely observed during cancer development to confer cancer cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting, conditions. It is famously known that cancer cells favor the "Warburg effect …
Metabolic reprogramming is widely observed during cancer development to confer cancer cells the ability to survive and proliferate, e …
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q. Li L, et al. Cancer Cell. 2018 Mar 12;33(3):368-385.e7. doi: 10.1016/j.ccell.2018.01.010. Epub 2018 Feb 15. Cancer Cell. 2018. PMID: 29455928 Free article.
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly …
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. …
Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells.
Fukushi A, Kim HD, Chang YC, Kim CH. Fukushi A, et al. Int J Mol Sci. 2022 Sep 2;23(17):10037. doi: 10.3390/ijms231710037. Int J Mol Sci. 2022. PMID: 36077431 Free PMC article. Review.
If the basic properties of the Warburg effect, including genetic mutations and signaling shifts are considered, anti-cancer therapeutic targets can be raised. Specific therapeutics targeting metabolic enzymes in aerobic glycolysis and hypoxic microenvironments have …
If the basic properties of the Warburg effect, including genetic mutations and signaling shifts are considered, anti-cancer th …
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS. Park MK, et al. Cell Metab. 2021 Dec 7;33(12):2380-2397.e9. doi: 10.1016/j.cmet.2021.11.011. Cell Metab. 2021. PMID: 34879239 Free PMC article.
Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying molecular mechanisms and their role in cancer progression remain poorly understood. ...These findings establish a direct role for NEAT1 in regulating tumor metabolism, provide new in …
Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying molecular mechanisms and their role in can …
ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.
Ma WK, Voss DM, Scharner J, Costa ASH, Lin KT, Jeon HY, Wilkinson JE, Jackson M, Rigo F, Bennett CF, Krainer AR. Ma WK, et al. Cancer Res. 2022 Mar 1;82(5):900-915. doi: 10.1158/0008-5472.CAN-20-0948. Cancer Res. 2022. PMID: 34921016 Free PMC article.
The M2 pyruvate kinase (PKM2) isoform is upregulated in most cancers and plays a crucial role in regulation of the Warburg effect, which is characterized by the preference for aerobic glycolysis over oxidative phosphorylation for energy metabolism. ...SIGNIFICANCE: …
The M2 pyruvate kinase (PKM2) isoform is upregulated in most cancers and plays a crucial role in regulation of the Warburg effect …
NUSAP1-LDHA-Glycolysis-Lactate feedforward loop promotes Warburg effect and metastasis in pancreatic ductal adenocarcinoma.
Chen M, Cen K, Song Y, Zhang X, Liou YC, Liu P, Huang J, Ruan J, He J, Ye W, Wang T, Huang X, Yang J, Jia Y, Liang X, Shen P, Wang Q, Liang T. Chen M, et al. Cancer Lett. 2023 Jul 28;567:216285. doi: 10.1016/j.canlet.2023.216285. Epub 2023 Jun 22. Cancer Lett. 2023. PMID: 37354982
And the regulation of NUSAP1 on Lactate dehydrogenase A (LDHA)-mediated glycolysis and its underlying mechanism was further clarified by CHIP-seq. NUSAP1 was an independent unfavorable predictor of PDAC prognosis that playing a critical role in metastasis of PDAC by regula …
And the regulation of NUSAP1 on Lactate dehydrogenase A (LDHA)-mediated glycolysis and its underlying mechanism was further clarified by CHI …
Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1alpha/HK2.
Cao L, Wang M, Dong Y, Xu B, Chen J, Ding Y, Qiu S, Li L, Karamfilova Zaharieva E, Zhou X, Xu Y. Cao L, et al. Cell Death Dis. 2020 Feb 24;11(2):145. doi: 10.1038/s41419-020-2336-0. Cell Death Dis. 2020. PMID: 32094325 Free PMC article.
CircRNA microarray sequencing revealed that circRNF20 was one of the upregulated transcripts in BC samples. Increased circRNF20 level predicted the poor clinical outcome in BC specimens. Functionally, circRNF20 promoted the proliferation and Warburg effect (a …
CircRNA microarray sequencing revealed that circRNF20 was one of the upregulated transcripts in BC samples. Increased circRNF20 level pre …
694 results