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Year Number of Results
1999 1
2004 1
2005 1
2007 3
2008 2
2010 3
2011 3
2012 12
2013 12
2014 17
2015 25
2016 21
2017 21
2018 16
2019 30
2020 36
2021 45
2022 40
2023 33
2024 7

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Page 1
Lactate metabolism in human health and disease.
Li X, Yang Y, Zhang B, Lin X, Fu X, An Y, Zou Y, Wang JX, Wang Z, Yu T. Li X, et al. Signal Transduct Target Ther. 2022 Sep 1;7(1):305. doi: 10.1038/s41392-022-01151-3. Signal Transduct Target Ther. 2022. PMID: 36050306 Free PMC article. Review.
The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging sig …
The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by …
Glutamine Metabolism in Cancer.
Li T, Copeland C, Le A. Li T, et al. Adv Exp Med Biol. 2021;1311:17-38. doi: 10.1007/978-3-030-65768-0_2. Adv Exp Med Biol. 2021. PMID: 34014532 Free PMC article.
These cells display crucial modifications in many metabolic pathways, such as glycolysis and glutaminolysis, which include the tricarboxylic acid (TCA) cycle, the electron transport chain (ETC), and the pentose phosphate pathway (PPP) [1]. Since the discovery of the Warburg …
These cells display crucial modifications in many metabolic pathways, such as glycolysis and glutaminolysis, which include the tricarboxylic …
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect.
Luo P, Zhang Q, Zhong TY, Chen JY, Zhang JZ, Tian Y, Zheng LH, Yang F, Dai LY, Zou C, Li ZJ, Liu JH, Wang JG. Luo P, et al. Mil Med Res. 2022 May 20;9(1):22. doi: 10.1186/s40779-022-00381-4. Mil Med Res. 2022. PMID: 35596191 Free PMC article.
Cel bound to Cys424 of pyruvate kinase M2 (PKM2), inhibiting the enzyme and thereby suppressing aerobic glycolysis (Warburg effect). Cel also bound to Cys106 in high mobility group box 1 (HMGB1) protein, reducing the secretion of inflammatory cytokine interleukin (I …
Cel bound to Cys424 of pyruvate kinase M2 (PKM2), inhibiting the enzyme and thereby suppressing aerobic glycolysis (Warburg effect …
Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer.
Kasprzak A. Kasprzak A. Int J Mol Sci. 2021 Jun 16;22(12):6434. doi: 10.3390/ijms22126434. Int J Mol Sci. 2021. PMID: 34208601 Free PMC article. Review.
However, the underlying mechanisms linking IGF-1 and MetS are still poorly understood. Hyperactivated glucose uptake and aerobic glycolysis (the Warburg effect) are considered as a one of six hallmarks of cancer, including CRC. ...This review describes the role of I …
However, the underlying mechanisms linking IGF-1 and MetS are still poorly understood. Hyperactivated glucose uptake and aerobic glycolysis …
Could ketogenic diet "starve" cancer? Emerging evidence.
Barrea L, Caprio M, Tuccinardi D, Moriconi E, Di Renzo L, Muscogiuri G, Colao A, Savastano S; Obesity Programs of nutrition, Education, Research and Assessment (OPERA) group. Barrea L, et al. Crit Rev Food Sci Nutr. 2022;62(7):1800-1821. doi: 10.1080/10408398.2020.1847030. Epub 2020 Dec 4. Crit Rev Food Sci Nutr. 2022. PMID: 33274644 Free article. Review.
Cancer cells (CCs) predominantly use aerobic glycolysis (Warburg effect) for their metabolism. This important characteristic of CCs represents a potential metabolic pathway to be targeted in the context of tumor treatment. ...
Cancer cells (CCs) predominantly use aerobic glycolysis (Warburg effect) for their metabolism. This important characteristic o …
Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes.
Mu X, Xiang Z, Xu Y, He J, Lu J, Chen Y, Wang X, Tu CR, Zhang Y, Zhang W, Yin Z, Leung WH, Lau YL, Liu Y, Tu W. Mu X, et al. Cell Mol Immunol. 2022 Aug;19(8):944-956. doi: 10.1038/s41423-022-00894-x. Epub 2022 Jul 11. Cell Mol Immunol. 2022. PMID: 35821253 Free PMC article.
The effect of glucose metabolism on gammadelta T cells and their impact on tumor surveillance remain unknown. Here, we showed that high glucose induced Warburg effect type of bioenergetic profile in Vgamma9Vdelta2 T cells, leading to excessive lactate accumulation, …
The effect of glucose metabolism on gammadelta T cells and their impact on tumor surveillance remain unknown. Here, we showed that high gluc …
Ketogenic Diet for Cancer: Critical Assessment and Research Recommendations.
Lane J, Brown NI, Williams S, Plaisance EP, Fontaine KR. Lane J, et al. Nutrients. 2021 Oct 12;13(10):3562. doi: 10.3390/nu13103562. Nutrients. 2021. PMID: 34684564 Free PMC article. Review.
The mechanisms underlying the hypothesized effects of KD, most notably the Warburg Effect, suggest that restricting carbohydrate content may impede cancer development and progression via several pathways (e.g., tumor metabolism, gene expression). ...
The mechanisms underlying the hypothesized effects of KD, most notably the Warburg Effect, suggest that restricting carbohydra …
Formaldehyde: Another hormesis-inducing chemical.
Agathokleous E, Calabrese EJ. Agathokleous E, et al. Environ Res. 2021 Aug;199:111395. doi: 10.1016/j.envres.2021.111395. Epub 2021 May 25. Environ Res. 2021. PMID: 34048749 Review.
In various animal cells, hormesis was observed in cell proliferation and viability, responses that were related to mechanisms, such as activation of phosphorylated ERK (extra-cellular signaling-regulated kinase) expression, acceleration of the process of cell division, and enhanc …
In various animal cells, hormesis was observed in cell proliferation and viability, responses that were related to mechanisms, such as activ …
Glutamine Metabolism in Cancer.
Li T, Le A. Li T, et al. Adv Exp Med Biol. 2018;1063:13-32. doi: 10.1007/978-3-319-77736-8_2. Adv Exp Med Biol. 2018. PMID: 29946773 Review.
These cells display crucial modifications in many metabolic pathways, including glucose transport, glutaminolysis which includes the tricarboxylic acid (TCA) cycle, the electron transport chain (ETC), and the pentose phosphate pathway (PPP) [1]. Since the discovery of the Warb …
These cells display crucial modifications in many metabolic pathways, including glucose transport, glutaminolysis which includes the tricarb …
278 results