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1989 1
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2010 2
2011 3
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Page 1
Pharmacometabonomics Technique to Identify Warfarin Response Using Nuclear Magnetic Resonance Spectroscopy.
Bawadikji AA, Teh CH, Kader MABSA, Sulaiman SAS, Ibrahim B. Bawadikji AA, et al. Curr Pharm Biotechnol. 2017;18(9):740-747. doi: 10.2174/1389201018666171103141828. Curr Pharm Biotechnol. 2017. PMID: 29110602 Review.
Thus, a technique such as NMR based pharmacometabonomics to find novel biomarkers in plasma and urine might be useful to predict warfarin outcome....
Thus, a technique such as NMR based pharmacometabonomics to find novel biomarkers in plasma and urine might be useful to predict warf …
The importance of including African populations in pharmacogenetics studies of warfarin response.
Dandara C, Ndadza A, Soko N. Dandara C, et al. Pharmacogenomics. 2022 Jan;23(1):1-4. doi: 10.2217/pgs-2021-0142. Epub 2021 Nov 25. Pharmacogenomics. 2022. PMID: 34821506
Tweetable abstract Warfarin will remain in use for a long time to come, thus inclusion of African populations in pharmacogenomics is essential to be able to identify all possible biomarkers that are potential predictors for warfarin drug response. Tweetable abstract Warfar …
Tweetable abstract Warfarin will remain in use for a long time to come, thus inclusion of African populations in pharmacogenomics is essenti …
Association between apolipoprotein E genotype and warfarin response during initial anticoagulation.
He S, Zhang H, Cao Y, Nian F, Chen H, Chen W, Auchoybur ML, Yin L, Tao Z, Tang S, Chen X. He S, et al. Biomed Pharmacother. 2018 May;101:251-256. doi: 10.1016/j.biopha.2018.02.095. Epub 2018 Feb 27. Biomed Pharmacother. 2018. PMID: 29494962

Compared with patients with the epsilon3/epsilon3 genotype, patients with at least one epsilon4 allele had significantly longer times to the first INR of more than 4 during both the initial 20 days (P = 0.001, HR 2.9; 95%CI, 1.54-5.45) and the entire follow-up period (P < 0.00

…
Compared with patients with the epsilon3/epsilon3 genotype, patients with at least one epsilon4 allele had significantly longer times to the …
Impact of CYP2C9-Interacting Drugs on Warfarin Pharmacogenomics.
Agrawal S, Heiss MS, Fenter RB, Abramova TV, Perera MA, Pacheco JA, Smith ME, Rasmussen-Torvik LJ, George AL Jr. Agrawal S, et al. Clin Transl Sci. 2020 Sep;13(5):941-949. doi: 10.1111/cts.12781. Epub 2020 Apr 9. Clin Transl Sci. 2020. PMID: 32270628 Free PMC article.
We investigated retrospectively the combined effects of cytochrome P450 (CYP)2C9 and vitamin K epoxide reductase complex (VKORC)1 genotypes and concurrent exposure to CYP2C9-interacting drugs on long-term measures of warfarin anticoagulation. Study participants predicted t …
We investigated retrospectively the combined effects of cytochrome P450 (CYP)2C9 and vitamin K epoxide reductase complex (VKORC)1 genotypes …
Is personalized medicine a dream or a reality?
Morse BL, Kim RB. Morse BL, et al. Crit Rev Clin Lab Sci. 2015 Feb;52(1):1-11. doi: 10.3109/10408363.2014.950407. Epub 2014 Sep 2. Crit Rev Clin Lab Sci. 2015. PMID: 25181036
Personalized medicine is an emerging field with a goal of applying genomic information as a predictor of disease risk as well as individualization of drug therapy. For optimization of drug therapy, significant progress has been made in the past decade in linking genetic va …
Personalized medicine is an emerging field with a goal of applying genomic information as a predictor of disease risk as well as indi …
Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.
Gong IY, Schwarz UI, Crown N, Dresser GK, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Wells PS, Kim RB, Tirona RG. Gong IY, et al. PLoS One. 2011;6(11):e27808. doi: 10.1371/journal.pone.0027808. Epub 2011 Nov 16. PLoS One. 2011. PMID: 22114699 Free PMC article.
To demonstrate the utility of the global PK-PD model, we compared the predicted initial anticoagulation responses with previously established warfarin dosing algorithms. ...
To demonstrate the utility of the global PK-PD model, we compared the predicted initial anticoagulation responses with previously est …
Predicting Range of Initial Warfarin Dose Based on Pharmacometabolomic and Genetic Inputs.
Huang Q, Cao L, Luo N, Qian H, Wei M, Xue L, Zhou Q, Zou B, Tan L, Chu Y, Ma X, Wang C, Wu H, Zhang L, Sun L, Li D, Fan X, Miao L, Zhou G. Huang Q, et al. Clin Pharmacol Ther. 2021 Dec;110(6):1585-1594. doi: 10.1002/cpt.2407. Epub 2021 Sep 13. Clin Pharmacol Ther. 2021. PMID: 34460938
With these biomarkers, a machine learning algorithm (two-dimensional linear discriminant analysis-multinomial logit model) was used to predict the subgroups with extremely warfarin-sensitive or less warfarin-sensitive patients with a prediction accuracy of 91% for t …
With these biomarkers, a machine learning algorithm (two-dimensional linear discriminant analysis-multinomial logit model) was used to pr …
Urine Metabolites as a Predictor of Warfarin Response Based on INR in Atrial Fibrillation.
Bawadikji AA, Teh CH, Kader MABSA, Sulaiman SAS, Ibrahim B. Bawadikji AA, et al. Curr Drug Metab. 2022 Aug 3;23(5):415-422. doi: 10.2174/1389200223666220413112649. Curr Drug Metab. 2022. PMID: 35422207
OBJECTIVES: The focus of this research was to determine if urine metabolites could predict the warfarin response based on INR in patients who were already taking warfarin (identification; phase I) and to determine if urine metabolites could distinguish between unstable and …
OBJECTIVES: The focus of this research was to determine if urine metabolites could predict the warfarin response based on INR in pati …
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.
Jorgensen AL, Al-Zubiedi S, Zhang JE, Keniry A, Hanson A, Hughes DA, Eker Dv, Stevens L, Hawkins K, Toh CH, Kamali F, Daly AK, Fitzmaurice D, Coffey A, Williamson PR, Park BK, Deloukas P, Pirmohamed M. Jorgensen AL, et al. Pharmacogenet Genomics. 2009 Oct;19(10):800-12. doi: 10.1097/FPC.0b013e3283317ab5. Pharmacogenet Genomics. 2009. PMID: 19752777 Free PMC article. Clinical Trial.
On the basis of the results of microcosting, adverse events were shown to be a significant predictor of total cost. CONCLUSION: Accurate prediction of warfarin dose requirement needs to take into account multiple genetic and environmental factors, the contributions …
On the basis of the results of microcosting, adverse events were shown to be a significant predictor of total cost. CONCLUSION: Accur …
40 results