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Year Number of Results
1989 1
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1992 2
1993 4
1994 2
1995 4
1996 2
1997 3
1998 1
1999 1
2000 4
2002 1
2003 1
2004 1
2005 3
2007 4
2008 3
2009 2
2010 1
2011 4
2012 1
2013 2
2014 2
2015 1
2016 3
2017 2
2018 3
2019 3
2020 2
2023 2
2024 0

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65 results

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Page 1
X chromosome linked immunodeficiency.
Schwaber J, Rosen FS. Schwaber J, et al. Immunodefic Rev. 1990;2(3):233-51. Immunodefic Rev. 1990. PMID: 1981831 Review.
X-linked chronic granulomatous disease and Wiskott-Aldrich syndrome map to loci on the short arm of the X chromosome; X-linked severe combined immunodeficiency, X-linked agammaglobulinemia, X-linked immunodeficiency with hyper-IgM, and X-linked …
X-linked chronic granulomatous disease and Wiskott-Aldrich syndrome map to loci on the short arm of the X chromosome; X-linked …
A modified gamma-retrovirus vector for X-linked severe combined immunodeficiency.
Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernández KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot F, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD, Fischer A, Kohn DB, Filipovich AH, Notarangelo LD, Cavazzana M, Williams DA, Thrasher AJ. Hacein-Bey-Abina S, et al. N Engl J Med. 2014 Oct 9;371(15):1407-17. doi: 10.1056/NEJMoa1404588. N Engl J Med. 2014. PMID: 25295500 Free PMC article. Clinical Trial.
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based gamma-retrovirus vector expressing interleukin-2 receptor gamma-chain (gammac) complementa …
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency …
Thymocytes self-renewal: a major hope or a major threat?
Peaudecerf L, Krenn G, Gonçalves P, Vasseur F, Rocha B. Peaudecerf L, et al. Immunol Rev. 2016 May;271(1):173-84. doi: 10.1111/imr.12408. Immunol Rev. 2016. PMID: 27088914 Review.
These results indicate a potential use of neonatal thymus transplants to correct T-cell intrinsic deficiencies. The other group observed that continuous thymocyte renewal from BM precursors was fundamental to prevent tumor development. ...Moreover, they suggested that the …
These results indicate a potential use of neonatal thymus transplants to correct T-cell intrinsic deficiencies. The other group observed …
Thymus autonomy as a prelude to leukemia.
Paiva RA, Ramos CV, Martins VC. Paiva RA, et al. FEBS J. 2018 Dec;285(24):4565-4574. doi: 10.1111/febs.14651. Epub 2018 Sep 17. FEBS J. 2018. PMID: 30187694 Free article.
If cell competition is impaired and no cells seed the thymus, the organ is capable of sustaining T lymphocyte production, a state termed thymus autonomy. However, we observed consistently that prolonged autonomy is permissive to the emergence of T cell acute lymphoblastic …
If cell competition is impaired and no cells seed the thymus, the organ is capable of sustaining T lymphocyte production, a state termed thy …
Review: Oncogenic Insertional Mutagenesis as a Consequence of Retroviral Gene Therapy for X-Linked Severe Combined Immunodeficiency Disease.
Ahmed B, Zafar M, Qadir MI. Ahmed B, et al. Crit Rev Eukaryot Gene Expr. 2019;29(6):511-520. doi: 10.1615/CritRevEukaryotGeneExpr.2019026820. Crit Rev Eukaryot Gene Expr. 2019. PMID: 32422006 Review.
For X-linked severe combined immunodeficiency (SCID-X1), the practice of gene therapy has revealed an unusual effect: insertional mutagenesis that can lead to leukemia. Even though incorporation of the retrovirus close to the oncogene for T-cell …
For X-linked severe combined immunodeficiency (SCID-X1), the practice of gene therapy has revealed an unu …
Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia.
Ginn SL, Curtin JA, Kramer B, Smyth CM, Wong M, Kakakios A, McCowage GB, Watson D, Alexander SI, Latham M, Cunningham SC, Zheng M, Hobson L, Rowe PB, Fischer A, Cavazzana-Calvo M, Hacein-Bey-Abina S, Alexander IE. Ginn SL, et al. Med J Aust. 2005 May 2;182(9):458-63. doi: 10.5694/j.1326-5377.2005.tb06785.x. Med J Aust. 2005. PMID: 15865589
OBJECTIVE: To report the outcome of gene therapy in an infant with X-linked severe combined immunodeficiency (SCID-X1), which typically causes a lack of T and natural killer (NK) cells. ...Gene-modified cells (equivalent to 1.3 x 10(6) CD34+/gam …
OBJECTIVE: To report the outcome of gene therapy in an infant with X-linked severe combined immunodeficiency …
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.
Wu C, Dunbar CE. Wu C, et al. Front Med. 2011 Dec;5(4):356-71. doi: 10.1007/s11684-011-0159-1. Epub 2011 Dec 27. Front Med. 2011. PMID: 22198747 Free PMC article. Review.
To date, HSC gene therapy has been successfully employed in the clinic for improving clinical outcomes in small numbers of patients with X-linked severe combined immunodeficiency (SCID-X1), adenosine deaminase deficiency (ADA-SCID), adrenoleukod …
To date, HSC gene therapy has been successfully employed in the clinic for improving clinical outcomes in small numbers of patients with …
Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development.
Leonard WJ, Shores EW, Love PE. Leonard WJ, et al. Immunol Rev. 1995 Dec;148:97-114. doi: 10.1111/j.1600-065x.1995.tb00095.x. Immunol Rev. 1995. PMID: 8825284 Review.
To examine the role of gamma c in lymphoid development, we have analyzed mice in which the gamma c gene was specifically inactivated by homologous recombination. These mice also serve as an animal model of human X-linked severe combined immunodefici …
To examine the role of gamma c in lymphoid development, we have analyzed mice in which the gamma c gene was specifically inactivated by homo …
Nuclease-free Adeno-Associated Virus-Mediated Il2rg Gene Editing in X-SCID Mice.
Hiramoto T, Li LB, Funk SE, Hirata RK, Russell DW. Hiramoto T, et al. Mol Ther. 2018 May 2;26(5):1255-1265. doi: 10.1016/j.ymthe.2018.02.028. Epub 2018 Mar 6. Mol Ther. 2018. PMID: 29606506 Free PMC article.
X-linked severe combined immunodeficiency (X-SCID) has been successfully treated by hematopoietic stem cell (HSC) transduction with retroviral vectors expressing the interleukin-2 receptor subunit gamma gene (IL2RG), but several patients develop …
X-linked severe combined immunodeficiency (X-SCID) has been successfully treated by hematopoietic stem ce …
Carrier and prenatal diagnosis of X-linked severe combined immunodeficiency: mutation detection methods and utilization.
Puck JM, Middelton L, Pepper AE. Puck JM, et al. Hum Genet. 1997 May;99(5):628-33. doi: 10.1007/s004390050418. Hum Genet. 1997. PMID: 9150730
Originally using linkage analysis and, more recently, specific detection of IL2RG mutations, we evaluated pregnancies at risk for X-linked SCID prospectively on a research basis. Of 27 male fetuses tested 14 were predicted to be unaffected and confirmed to have normal immu …
Originally using linkage analysis and, more recently, specific detection of IL2RG mutations, we evaluated pregnancies at risk for X-linked S …
65 results