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Page 1
Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes.
J Exp Med. 2020 Jun 1;217(6):e20192362. doi: 10.1084/jem.20192362.
J Exp Med. 2020.
PMID: 32251514
Free PMC article.
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.
Wan X, Zinselmeyer BH, Zakharov PN, Vomund AN, Taniguchi R, Santambrogio L, Anderson MS, Lichti CF, Unanue ER.
Wan X, et al. Among authors: zakharov pn.
Nature. 2018 Aug;560(7716):107-111. doi: 10.1038/s41586-018-0341-6. Epub 2018 Jul 18.
Nature. 2018.
PMID: 30022165
Free PMC article.
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Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice.
Hu H, Zakharov PN, Peterson OJ, Unanue ER.
Hu H, et al. Among authors: zakharov pn.
Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31319-31330. doi: 10.1073/pnas.2019743117. Epub 2020 Nov 23.
Proc Natl Acad Sci U S A. 2020.
PMID: 33229539
Free PMC article.
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The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.
Ferris ST, Zakharov PN, Wan X, Calderon B, Artyomov MN, Unanue ER, Carrero JA.
Ferris ST, et al. Among authors: zakharov pn.
J Exp Med. 2017 Aug 7;214(8):2369-2385. doi: 10.1084/jem.20170074. Epub 2017 Jun 19.
J Exp Med. 2017.
PMID: 28630088
Free PMC article.
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CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity.
Srivastava N, Hu H, Peterson OJ, Vomund AN, Stremska M, Zaman M, Giri S, Li T, Lichti CF, Zakharov PN, Zhang B, Abumrad NA, Chen YG, Ravichandran KS, Unanue ER, Wan X.
Srivastava N, et al. Among authors: zakharov pn.
Immunity. 2024 May 6:S1074-7613(24)00222-X. doi: 10.1016/j.immuni.2024.04.017. Online ahead of print.
Immunity. 2024.
PMID: 38754432
Free article.
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