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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 2
1952 1
1955 2
1956 1
1957 2
1960 1
1961 1
1962 2
1963 1
1967 1
1970 1
1971 1
1972 1
1974 1
1975 6
1976 6
1977 4
1978 9
1979 11
1980 9
1981 12
1982 9
1983 12
1984 14
1985 14
1986 16
1987 17
1988 17
1989 18
1990 32
1991 18
1992 44
1993 42
1994 53
1995 45
1996 36
1997 51
1998 68
1999 42
2000 48
2001 42
2002 58
2003 59
2004 66
2005 61
2006 79
2007 90
2008 94
2009 85
2010 96
2011 114
2012 97
2013 113
2014 111
2015 114
2016 121
2017 117
2018 104
2019 105
2020 116
2021 139
2022 111
2023 119
2024 34

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2,635 results

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Page 1
Molecular genetics of beta-thalassemia: A narrative review.
Jaing TH, Chang TY, Chen SH, Lin CW, Wen YC, Chiu CC. Jaing TH, et al. Medicine (Baltimore). 2021 Nov 12;100(45):e27522. doi: 10.1097/MD.0000000000027522. Medicine (Baltimore). 2021. PMID: 34766559 Free PMC article. Review.
beta-thalassemia is a hereditary hematological disease caused by over 350 mutations in the beta-globin gene (HBB). Identifying the genetic variants affecting fetal hemoglobin (HbF) production combined with the alpha-globin genotype provides some prediction of …
beta-thalassemia is a hereditary hematological disease caused by over 350 mutations in the beta-globin gene (HBB). Identifying …
Fetal Hemoglobin Regulation in Beta-Thalassemia.
Lu HY, Orkin SH, Sankaran VG. Lu HY, et al. Hematol Oncol Clin North Am. 2023 Apr;37(2):301-312. doi: 10.1016/j.hoc.2022.12.002. Hematol Oncol Clin North Am. 2023. PMID: 36907604 Review.
beta-thalassemia is caused by mutations that reduce beta-globin production, causing globin chain imbalance, ineffective erythropoiesis, and consequent anemia. Increased fetal hemoglobin (HbF) levels can ameliorate the severity of beta-thalassemia by co …
beta-thalassemia is caused by mutations that reduce beta-globin production, causing globin chain imbalance, ineffective erythr …
Beta-thalassaemia.
Thein SL. Thein SL. Baillieres Clin Haematol. 1998 Mar;11(1):91-126. doi: 10.1016/s0950-3536(98)80071-1. Baillieres Clin Haematol. 1998. PMID: 10872474 Review.
The presence of other interacting loci is implicated by their interactions in increasing gamma gene expression or by an increased proteolytic capacity of the erythroid precursors. It is hoped that observations from the genotype-phenotype relationship might form the basis f …
The presence of other interacting loci is implicated by their interactions in increasing gamma gene expression or by an increased proteolyti …
Homeobox A5 and A9 expression and beta-thalassemia.
Badr E, El-Sayed IT, Alasadi M. Badr E, et al. Br J Biomed Sci. 2021 Jul;78(3):117-121. doi: 10.1080/09674845.2021.1877926. Epub 2021 Mar 12. Br J Biomed Sci. 2021. PMID: 33461426
Background and aim: The pathogenesis of beta-thalassemia has been attributed to ineffective erythropoiesis. ...HoxA gene expression is a promising diagnostic and prognostic marker in patients with beta-thalassemia....
Background and aim: The pathogenesis of beta-thalassemia has been attributed to ineffective erythropoiesis. ...HoxA gene expre …
Pathomechanisms of Immunological Disturbances in beta-Thalassemia.
Gluba-Brzózka A, Franczyk B, Rysz-Górzyńska M, Rokicki R, Koziarska-Rościszewska M, Rysz J. Gluba-Brzózka A, et al. Int J Mol Sci. 2021 Sep 7;22(18):9677. doi: 10.3390/ijms22189677. Int J Mol Sci. 2021. PMID: 34575839 Free PMC article. Review.
Thalassemia, a chronic disease with chronic anemia, is caused by mutations in the beta-globin gene, leading to reduced levels or complete deficiency of beta-globin chain synthesis. Patients with beta-thalassemia display variable clinical severity which ranges from a …
Thalassemia, a chronic disease with chronic anemia, is caused by mutations in the beta-globin gene, leading to reduced levels or complete de …
Prediction of Heart and Liver Iron Overload in beta-Thalassemia Major Patients Using Machine Learning Methods.
Asmarian N, Kamalipour A, Hosseini-Bensenjan M, Karimi M, Haghpanah S. Asmarian N, et al. Hemoglobin. 2022 Nov;46(6):303-307. doi: 10.1080/03630269.2022.2158100. Epub 2023 Feb 7. Hemoglobin. 2022. PMID: 36748392
Patients with beta-thalassemia major (beta-TM) face a wide range of complications as a result of excess iron in vital organs, including the heart and liver. ...Ferritin, duration of transfusion, and age were determined as the most effective predictors of iron …
Patients with beta-thalassemia major (beta-TM) face a wide range of complications as a result of excess iron in vital organs, …
beta-thalassemia intermedia: a clinical perspective.
Musallam KM, Taher AT, Rachmilewitz EA. Musallam KM, et al. Cold Spring Harb Perspect Med. 2012 Jul;2(7):a013482. doi: 10.1101/cshperspect.a013482. Cold Spring Harb Perspect Med. 2012. PMID: 22762026 Free PMC article. Review.
Our understanding of the molecular and pathophysiological mechanisms underlying the disease process in patients with beta-thalassemia intermedia has substantially increased over the past decade. Earlier studies observed that patients with beta-thala …
Our understanding of the molecular and pathophysiological mechanisms underlying the disease process in patients with beta-thalasse …
Predictive SNPs for beta(0)-thalassemia/HbE disease severity.
Munkongdee T, Tongsima S, Ngamphiw C, Wangkumhang P, Peerapittayamongkol C, Hashim HB, Fucharoen S, Svasti S. Munkongdee T, et al. Sci Rep. 2021 May 14;11(1):10352. doi: 10.1038/s41598-021-89641-2. Sci Rep. 2021. PMID: 33990643 Free PMC article.
A thalassemia severity score has been developed from Mediterranean beta-thalassemia patients. ...The SNP risk score could be used for prediction of clinical severity for Southeast Asia beta(0)-thalassemia/HbE population....
A thalassemia severity score has been developed from Mediterranean beta-thalassemia patients. ...The SNP risk score …
Molecular basis of beta thalassemia and potential therapeutic targets.
Thein SL. Thein SL. Blood Cells Mol Dis. 2018 May;70:54-65. doi: 10.1016/j.bcmd.2017.06.001. Epub 2017 Jun 20. Blood Cells Mol Dis. 2018. PMID: 28651846 Free PMC article. Review.
The remarkable phenotypic diversity of beta thalassemia that range from severe anemia and transfusion-dependency, to a clinically asymptomatic state exemplifies how a spectrum of disease severity can be generated in single gene disorders. ...Identification of the ge …
The remarkable phenotypic diversity of beta thalassemia that range from severe anemia and transfusion-dependency, to a clinica …
Genetic Basis and Genetic Modifiers of beta-Thalassemia and Sickle Cell Disease.
Thein SL. Thein SL. Adv Exp Med Biol. 2017;1013:27-57. doi: 10.1007/978-1-4939-7299-9_2. Adv Exp Med Biol. 2017. PMID: 29127676 Review.
beta-thalassemia and sickle cell disease (SCD) are prototypical Mendelian single gene disorders, both caused by mutations affecting the adult beta-globin gene. ...Identification of the genetic variants modifying HbF production in combination with alpha-globin genoty …
beta-thalassemia and sickle cell disease (SCD) are prototypical Mendelian single gene disorders, both caused by mutations affe …
2,635 results