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Year Number of Results
1999 1
2001 1
2002 1
2003 3
2004 4
2005 59
2006 14
2007 84
2008 469
2009 1852
2010 2780
2011 3222
2012 3162
2013 3330
2014 3273
2015 3555
2016 3587
2017 3720
2018 3827
2019 4293
2020 4354
2021 5078
2022 4864
2023 5331
2024 2421

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52,327 results

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Page 1
['Millennium Project' of MHLW].
Tsujimoto G. Tsujimoto G. Nihon Rinsho. 2001 Oct;59(10):1884-8. Nihon Rinsho. 2001. PMID: 11676126 Review. Japanese.
In Japan, 'Millennium Project' based on SNPs has started in 2000, and National Research Centers of MHLW are performing genome-wide association study on five common diseases (dementia, cancer, diabetes mellitus, hypertension, and asthma/allergy). ...
In Japan, 'Millennium Project' based on SNPs has started in 2000, and National Research Centers of MHLW are performing genome-wide …
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease.
Carrasquillo MM, McCallion AS, Puffenberger EG, Kashuk CS, Nouri N, Chakravarti A. Carrasquillo MM, et al. Nat Genet. 2002 Oct;32(2):237-44. doi: 10.1038/ng998. Epub 2002 Sep 23. Nat Genet. 2002. PMID: 12355085
Mutations at individual loci are, however, neither necessary nor sufficient to cause clinical disease. We conducted a genome-wide association study in 43 Mennonite family trios using 2,083 microsatellites and single-nucleotide polymorphisms and a new m …
Mutations at individual loci are, however, neither necessary nor sufficient to cause clinical disease. We conducted a genome-wide …
Genetic aspects of diabetic nephropathy.
Lindner TH, Mönks D, Wanner C, Berger M. Lindner TH, et al. Kidney Int Suppl. 2003 May;(84):S186-91. doi: 10.1046/j.1523-1755.63.s84.24.x. Kidney Int Suppl. 2003. PMID: 12694341 Free article. Review.
With the development of better technologies for an affordable genome-wide association study using thousands of markers, it might become possible to unravel the genetic causes of diabetic nephropathy....
With the development of better technologies for an affordable genome-wide association study using thousands of m …
Multicenter initiative seeking critical genes in respiratory papillomatosis.
Buchinsky FJ, Derkay CS, Leal SM, Donfack J, Ehrlich GD, Post JC. Buchinsky FJ, et al. Laryngoscope. 2004 Feb;114(2):349-57. doi: 10.1097/00005537-200402000-00032. Laryngoscope. 2004. PMID: 14755217 Free PMC article.
Determining the host genes that govern susceptibility will enhance our understanding not only of RRP but also of host-viral interaction in general. STUDY DESIGN: A genome-wide association study on familial triads consisting of an RRP-affected child and …
Determining the host genes that govern susceptibility will enhance our understanding not only of RRP but also of host-viral interaction in g …
Genetics of myocardial infarction.
Topol EJ. Topol EJ. J Invasive Cardiol. 2004 Jul;16(7 Suppl):32S-35S. J Invasive Cardiol. 2004. PMID: 23573570
Genome-wide analysis of the parkinsonism-dementia complex of Guam.
Morris HR, Steele JC, Crook R, Wavrant-De Vrièze F, Onstead-Cardinale L, Gwinn-Hardy K, Wood NW, Farrer M, Lees AJ, McGeer PL, Siddique T, Hardy J, Perez-Tur J. Morris HR, et al. Arch Neurol. 2004 Dec;61(12):1889-97. doi: 10.1001/archneur.61.12.1889. Arch Neurol. 2004. PMID: 15596609
OBJECTIVE: To determine whether a genetic locus could be identified, linked, or associated with PDC. DESIGN AND PATIENTS: We performed a genome-wide association study of 22 Guamanian PDC and 19 control subjects using 834 microsatellite markers with an …
OBJECTIVE: To determine whether a genetic locus could be identified, linked, or associated with PDC. DESIGN AND PATIENTS: We performed a …
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines.
Smith MW, O'Brien SJ. Smith MW, et al. Nat Rev Genet. 2005 Aug;6(8):623-32. doi: 10.1038/nrg1657. Nat Rev Genet. 2005. PMID: 16012528 Review.
Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. ...
Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide associ …
Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis.
Laxton R, Pearce E, Kyriakou T, Ye S. Laxton R, et al. Genes Immun. 2005 Sep;6(6):539-41. doi: 10.1038/sj.gene.6364236. Genes Immun. 2005. PMID: 15973460
A recent large-scale, genome-wide association study of single nucleotide polymorphisms showed a strong association between susceptibility to myocardial infarction and the Thr26Asn polymorphism in the lymphotoxin-alpha (LTA) gene. ...
A recent large-scale, genome-wide association study of single nucleotide polymorphisms showed a strong associati …
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease.
Yamazaki K, McGovern D, Ragoussis J, Paolucci M, Butler H, Jewell D, Cardon L, Takazoe M, Tanaka T, Ichimori T, Saito S, Sekine A, Iida A, Takahashi A, Tsunoda T, Lathrop M, Nakamura Y. Yamazaki K, et al. Hum Mol Genet. 2005 Nov 15;14(22):3499-506. doi: 10.1093/hmg/ddi379. Epub 2005 Oct 12. Hum Mol Genet. 2005. PMID: 16221758
To identify genetic susceptibility factors in CD, we performed a genome-wide association study in Japanese patients and controls using nearly 80,000 gene-based single nucleotide polymorphism (SNP) markers and investigated the haplotype structure of the …
To identify genetic susceptibility factors in CD, we performed a genome-wide association study in Japanese patie …
Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans.
Bailey-Wilson JE, Almasy L, de Andrade M, Bailey J, Bickeböller H, Cordell HJ, Daw EW, Goldin L, Goode EL, Gray-McGuire C, Hening W, Jarvik G, Maher BS, Mendell N, Paterson AD, Rice J, Satten G, Suarez B, Vieland V, Wilcox M, Zhang H, Ziegler A, MacCluer JW. Bailey-Wilson JE, et al. BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S1. doi: 10.1186/1471-2156-6-S1-S1. BMC Genet. 2005. PMID: 16451554 Free PMC article. No abstract available.
Genomic screening in family-based association testing.
Murphy A, McQueen MB, Su J, Kraft P, Lazarus R, Laird NM, Lange C, Van Steen K. Murphy A, et al. BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S115. doi: 10.1186/1471-2156-6-S1-S115. BMC Genet. 2005. PMID: 16451572 Free PMC article.
Will the real disease gene please stand up?
Shephard N, John S, Cardon L, McCarthy MI, Zeggini E. Shephard N, et al. BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S66. doi: 10.1186/1471-2156-6-S1-S66. BMC Genet. 2005. PMID: 16451679 Free PMC article.
Genome-wide association study to identify single-nucleotide polymorphisms conferring risk of myocardial infarction.
Ozaki K, Tanaka T. Ozaki K, et al. Methods Mol Med. 2006;128:173-80. doi: 10.1007/978-1-59745-159-8_12. Methods Mol Med. 2006. PMID: 17071996
This chapter describes a detailed protocol for performing a genome-wide association study as used in our MI study....
This chapter describes a detailed protocol for performing a genome-wide association study as used in our MI stud …
A fast boosting-based screening method for large-scale association study in complex traits with genetic heterogeneity.
Wang LY, Fasulo D. Wang LY, et al. Conf Proc IEEE Eng Med Biol Soc. 2006;2006:5771-4. doi: 10.1109/IEMBS.2006.260585. Conf Proc IEEE Eng Med Biol Soc. 2006. PMID: 17946332
Genome-wide association study for complex diseases will generate massive amount of single nucleotide polymorphisms (SNPs) data. ...
Genome-wide association study for complex diseases will generate massive amount of single nucleotide polymorphis …
An utter refutation of the "fundamental theorem of the HapMap".
Terwilliger JD, Hiekkalinna T. Terwilliger JD, et al. Eur J Hum Genet. 2006 Apr;14(4):426-37. doi: 10.1038/sj.ejhg.5201583. Eur J Hum Genet. 2006. PMID: 16479260
The International HapMap Project was proposed in order to quantify linkage disequilibrium (LD) relationships among human DNA polymorphisms in an assortment of populations, in order to facilitate the process of selecting a minimal set of markers that could capture most of the sign …
The International HapMap Project was proposed in order to quantify linkage disequilibrium (LD) relationships among human DNA polymorphisms i …
Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia.
Mah S, Nelson MR, Delisi LE, Reneland RH, Markward N, James MR, Nyholt DR, Hayward N, Handoko H, Mowry B, Kammerer S, Braun A. Mah S, et al. Mol Psychiatry. 2006 May;11(5):471-8. doi: 10.1038/sj.mp.4001785. Mol Psychiatry. 2006. PMID: 16402134
Here, we report the identification of a novel schizophrenia candidate gene on chromosome 1q32, plexin A2 (PLXNA2), in a genome-wide association study using 320 patients with schizophrenia of European descent and 325 matched controls. ...
Here, we report the identification of a novel schizophrenia candidate gene on chromosome 1q32, plexin A2 (PLXNA2), in a genome-wid …
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marbán E, O'Donnell CJ, Hirschhorn JN, Kääb S, Spooner PM, Meitinger T, Chakravarti A. Arking DE, et al. Nat Genet. 2006 Jun;38(6):644-51. doi: 10.1038/ng1790. Epub 2006 Apr 30. Nat Genet. 2006. PMID: 16648850
We identified a common genetic variant influencing this quantitative trait through a genome-wide association study on 200 subjects at the extremes of a population-based QT interval distribution of 3,966 subjects from the KORA cohort in Germany, with fo …
We identified a common genetic variant influencing this quantitative trait through a genome-wide association study …
Variants in the GH-IGF axis confer susceptibility to lung cancer.
Rudd MF, Webb EL, Matakidou A, Sellick GS, Williams RD, Bridle H, Eisen T, Houlston RS; GELCAPS Consortium. Rudd MF, et al. Genome Res. 2006 Jun;16(6):693-701. doi: 10.1101/gr.5120106. Genome Res. 2006. PMID: 16741161 Free PMC article.
We conducted a large-scale genome-wide association study in UK Caucasians to identify susceptibility alleles for lung cancer, analyzing 1529 cases and 2707 controls. ...
We conducted a large-scale genome-wide association study in UK Caucasians to identify susceptibility alleles for …
Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorder.
Service S, Molina J, Deyoung J, Jawaheer D, Aldana I, Vu T, Araya C, Araya X, Bejarano J, Fournier E, Ramirez M, Mathews CA, Davanzo P, Macaya G, Sandkuijl L, Sabatti C, Reus V, Freimer N. Service S, et al. Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):367-73. doi: 10.1002/ajmg.b.30323. Am J Med Genet B Neuropsychiatr Genet. 2006. PMID: 16652356
The family was identified by tracing genealogical connections among eight persons initially independently ascertained for a genome wide association study of BP-I. For the genome screen in CR201, we trimmed the family down to 168 persons (82 of whom are …
The family was identified by tracing genealogical connections among eight persons initially independently ascertained for a genome …
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.
Elbaz A, Nelson LM, Payami H, Ioannidis JP, Fiske BK, Annesi G, Carmine Belin A, Factor SA, Ferrarese C, Hadjigeorgiou GM, Higgins DS, Kawakami H, Krüger R, Marder KS, Mayeux RP, Mellick GD, Nutt JG, Ritz B, Samii A, Tanner CM, Van Broeckhoven C, Van Den Eeden SK, Wirdefeldt K, Zabetian CP, Dehem M, Montimurro JS, Southwick A, Myers RM, Trikalinos TA. Elbaz A, et al. Lancet Neurol. 2006 Nov;5(11):917-23. doi: 10.1016/S1474-4422(06)70579-8. Lancet Neurol. 2006. PMID: 17052658 Free PMC article.
BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. ...INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the origi …
BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly a …
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. Duerr RH, et al. Science. 2006 Dec 1;314(5804):1461-3. doi: 10.1126/science.1135245. Epub 2006 Oct 26. Science. 2006. PMID: 17068223 Free PMC article.
To identify genetic factors that might contribute to these disorders, we performed a genome-wide association study. We found a highly significant association between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the …
To identify genetic factors that might contribute to these disorders, we performed a genome-wide association study …
Novel genes identified in a high-density genome wide association study for nicotine dependence.
Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, Montgomery GW, Saccone NL, Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG. Bierut LJ, et al. Hum Mol Genet. 2007 Jan 1;16(1):24-35. doi: 10.1093/hmg/ddl441. Epub 2006 Dec 7. Hum Mol Genet. 2007. PMID: 17158188 Free PMC article.
To identify novel genes for which natural variation contributes to the development of nicotine dependence, we performed a comprehensive genome wide association study using nicotine dependent smokers as cases and non-dependent smokers as controls. ...
To identify novel genes for which natural variation contributes to the development of nicotine dependence, we performed a comprehensive g …
Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish.
Post W, Shen H, Damcott C, Arking DE, Kao WH, Sack PA, Ryan KA, Chakravarti A, Mitchell BD, Shuldiner AR. Post W, et al. Hum Hered. 2007;64(4):214-9. doi: 10.1159/000103630. Epub 2007 Jun 12. Hum Hered. 2007. PMID: 17565224 Free PMC article.
BACKGROUND: Through a genome-wide association study, we discovered an association of the electrocardiographic QT interval with polymorphisms in the NOS1AP (CAPON) gene. ...
BACKGROUND: Through a genome-wide association study, we discovered an association of the electrocardiographic QT …
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.
Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB Sr, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. Cupples LA, et al. BMC Med Genet. 2007;8 Suppl 1(Suppl 1):S1. doi: 10.1186/1471-2350-8-S1-S1. BMC Med Genet. 2007. PMID: 17903291 Free PMC article.
CONCLUSION: We have created a full-disclosure resource of results, posted on the dbGaP website, from a genome-wide association study in the FHS. Because we used three analytical approaches to examine the association and linkage of 987 phenotypes with t …
CONCLUSION: We have created a full-disclosure resource of results, posted on the dbGaP website, from a genome-wide associat …
Designing candidate gene and genome-wide case-control association studies.
Zondervan KT, Cardon LR. Zondervan KT, et al. Nat Protoc. 2007;2(10):2492-501. doi: 10.1038/nprot.2007.366. Nat Protoc. 2007. PMID: 17947991 Free PMC article.
General guidelines are given, as well as specific examples of a CG and a genome-wide association study into type 2 diabetes. Software and websites used in this protocol include the International HapMap Consortium website, Genetic Power Calculator, CaT, …
General guidelines are given, as well as specific examples of a CG and a genome-wide association study into type …
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Günther S, Prescott NJ, Onnie CM, Häsler R, Sipos B, Fölsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S. Hampe J, et al. Nat Genet. 2007 Feb;39(2):207-11. doi: 10.1038/ng1954. Epub 2006 Dec 31. Nat Genet. 2007. PMID: 17200669
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. ...
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease …
Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22.
Kikuchi T, Naruse TK, Onizuka M, Li S, Kimura T, Oka A, Morishima Y, Kulski JK, Ichimiya S, Sato N, Inoko H. Kikuchi T, et al. Immunogenetics. 2007 Feb;59(2):99-108. doi: 10.1007/s00251-006-0186-2. Epub 2007 Jan 3. Immunogenetics. 2007. PMID: 17200870
To find novel susceptibility and/or protective loci for aGVHD, a whole genome-wide association study of donors and recipients needs to be performed. ...
To find novel susceptibility and/or protective loci for aGVHD, a whole genome-wide association study of donors a …
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P. Sladek R, et al. Nature. 2007 Feb 22;445(7130):881-5. doi: 10.1038/nature05616. Epub 2007 Feb 11. Nature. 2007. PMID: 17293876
Evidence for association between multiple complement pathway genes and AMD.
Dinu V, Miller PL, Zhao H. Dinu V, et al. Genet Epidemiol. 2007 Apr;31(3):224-37. doi: 10.1002/gepi.20204. Genet Epidemiol. 2007. PMID: 17266113
By focusing on the single nucleotide polymorphisms (SNPs) in the complement pathway, we were able to use the genotype data from a recently published AMD genome wide association study to identify two additional genes, C7 and MBL2, as potentially associa …
By focusing on the single nucleotide polymorphisms (SNPs) in the complement pathway, we were able to use the genotype data from a recently p …
Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data.
Schymick JC, Scholz SW, Fung HC, Britton A, Arepalli S, Gibbs JR, Lombardo F, Matarin M, Kasperaviciute D, Hernandez DG, Crews C, Bruijn L, Rothstein J, Mora G, Restagno G, Chiò A, Singleton A, Hardy J, Traynor BJ. Schymick JC, et al. Lancet Neurol. 2007 Apr;6(4):322-8. doi: 10.1016/S1474-4422(07)70037-6. Lancet Neurol. 2007. PMID: 17362836
We sought to identify genetic variants associated with an increased or decreased risk for developing ALS in a cohort of American sporadic cases. METHODS: We undertook a genome-wide association study using publicly available samples from 276 patients wi …
We sought to identify genetic variants associated with an increased or decreased risk for developing ALS in a cohort of American sporadic ca …
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J, Stephan DA. Coon KD, et al. J Clin Psychiatry. 2007 Apr;68(4):613-8. doi: 10.4088/jcp.v68n0419. J Clin Psychiatry. 2007. PMID: 17474819
We sought here to demonstrate that more precise identification of loci that are associated with complex, multi-genic genetic disorders can be achieved using ultra-high-density whole-genome associations by demonstrating their ability to identify the APOE locus as a major susceptib …
We sought here to demonstrate that more precise identification of loci that are associated with complex, multi-genic genetic disorders can b …
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.
Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, Brayne C, Rubinsztein D, Gill M, Lawlor B, Lovestone S, Holmans P, O'Donovan M, Morris JC, Thal L, Goate A, Owen MJ, Williams J. Grupe A, et al. Hum Mol Genet. 2007 Apr 15;16(8):865-73. doi: 10.1093/hmg/ddm031. Epub 2007 Feb 22. Hum Mol Genet. 2007. PMID: 17317784
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