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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 6
1974 3
1975 9
1976 9
1977 6
1978 12
1979 15
1980 13
1981 18
1982 10
1983 12
1984 31
1985 31
1986 43
1987 72
1988 91
1989 110
1990 122
1991 152
1992 141
1993 183
1994 197
1995 202
1996 237
1997 231
1998 241
1999 256
2000 243
2001 259
2002 287
2003 264
2004 282
2005 298
2006 331
2007 312
2008 338
2009 358
2010 375
2011 403
2012 426
2013 423
2014 431
2015 410
2016 423
2017 445
2018 404
2019 430
2020 407
2021 497
2022 440
2023 405
2024 204

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10,701 results

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Page 1
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.
Martinez NM, Su A, Burns MC, Nussbacher JK, Schaening C, Sathe S, Yeo GW, Gilbert WV. Martinez NM, et al. Mol Cell. 2022 Feb 3;82(3):645-659.e9. doi: 10.1016/j.molcel.2021.12.023. Epub 2022 Jan 19. Mol Cell. 2022. PMID: 35051350 Free PMC article.
In vitro splicing assays establish a direct effect of individual endogenous pre-mRNA pseudouridines on splicing efficiency. We validate hundreds of pre-mRNA sites as direct targets of distinct pseudouridine synthases and show that PUS1, PUS7, and RPUSD …
In vitro splicing assays establish a direct effect of individual endogenous pre-mRNA pseudouridines on splicing efficiency. We …
Pre-mRNA structures forming circular RNAs.
Welden JR, Stamm S. Welden JR, et al. Biochim Biophys Acta Gene Regul Mech. 2019 Nov-Dec;1862(11-12):194410. doi: 10.1016/j.bbagrm.2019.194410. Epub 2019 Aug 14. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 31421281 Review.
For back-splicing to occur, the back-splice sites must frequently be brought into close proximity, which is achieved through the formation of secondary structures in the pre-mRNA. In general, these pre-mRNA structures are formed by RNA base pairing bet …
For back-splicing to occur, the back-splice sites must frequently be brought into close proximity, which is achieved through the formation o …
Light-regulated pre-mRNA splicing in plants.
Kathare PK, Huq E. Kathare PK, et al. Curr Opin Plant Biol. 2021 Oct;63:102037. doi: 10.1016/j.pbi.2021.102037. Epub 2021 Apr 3. Curr Opin Plant Biol. 2021. PMID: 33823333 Free PMC article. Review.
Recent large-scale RNA-seq studies have demonstrated the roles of phys in altering the global transcript diversity by modulating the pre-mRNA splicing in response to light. Moreover, several phy-interacting splicing factors/regulators from different species have bee …
Recent large-scale RNA-seq studies have demonstrated the roles of phys in altering the global transcript diversity by modulating the pre …
Targeting pre-mRNA splicing in cancers: roles, inhibitors, and therapeutic opportunities.
Araki S, Ohori M, Yugami M. Araki S, et al. Front Oncol. 2023 Jun 5;13:1152087. doi: 10.3389/fonc.2023.1152087. eCollection 2023. Front Oncol. 2023. PMID: 37342192 Free PMC article. Review.
Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety of physiological processes, including development of multiple diseases. ...Furthermore, molecular mechanism-based combination strategies and patient stratification strategie …
Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety of physiological processes, inclu …
Pre-mRNA splicing.
Newman AJ. Newman AJ. Curr Opin Genet Dev. 1994 Apr;4(2):298-304. doi: 10.1016/s0959-437x(05)80057-7. Curr Opin Genet Dev. 1994. PMID: 8032208 Review.
Information from yeast and mammalian pre-mRNA splicing systems has advanced our understanding of the roles of protein factors in the early steps of spliceosome assembly. New results on the stereochemistry of nuclear pre-mRNA splicing and data on the tr …
Information from yeast and mammalian pre-mRNA splicing systems has advanced our understanding of the roles of protein factors …
Intron specificity in pre-mRNA splicing.
Mishra SK, Thakran P. Mishra SK, et al. Curr Genet. 2018 Aug;64(4):777-784. doi: 10.1007/s00294-017-0802-8. Epub 2018 Jan 3. Curr Genet. 2018. PMID: 29299619 Review.
Higher intronic density and diversity in genetically complex organisms relies on increased efficiency and accuracy of spliceosomes for pre-mRNA splicing. Since intron diversity is critical for functions in RNA stability, regulation of gene expression and alternative …
Higher intronic density and diversity in genetically complex organisms relies on increased efficiency and accuracy of spliceosomes for pr …
Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors.
Kretova M, Selicky T, Cipakova I, Cipak L. Kretova M, et al. Life (Basel). 2023 Feb 21;13(3):604. doi: 10.3390/life13030604. Life (Basel). 2023. PMID: 36983760 Free PMC article. Review.
Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. ...In recent years, various post-translational modifications of splicing factors have been shown to contribute significantly to regulation of pro …
Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. ...In …
Oncogenic dysregulation of pre-mRNA processing by protein kinases: challenges and therapeutic opportunities.
Naro C, Bielli P, Sette C. Naro C, et al. FEBS J. 2021 Nov;288(21):6250-6272. doi: 10.1111/febs.16057. Epub 2021 Jun 27. FEBS J. 2021. PMID: 34092037 Free PMC article. Review.
Alternative splicing and polyadenylation represent two major steps in pre-mRNA-processing, which ensure proper gene expression and diversification of human transcriptomes. ...A prominent role in fine-tuning pre-mRNA-processing mechanisms is played by t …
Alternative splicing and polyadenylation represent two major steps in pre-mRNA-processing, which ensure proper gene expression …
Insights from structures of cancer-relevant pre-mRNA splicing factors.
Kielkopf CL. Kielkopf CL. Curr Opin Genet Dev. 2018 Feb;48:57-66. doi: 10.1016/j.gde.2017.10.008. Epub 2017 Nov 10. Curr Opin Genet Dev. 2018. PMID: 29128695 Free PMC article. Review.
Pre-mRNA splicing factors recognize consensus signals within preliminary transcripts, and as cogs of the spliceosome machine, orchestrate the excision and rejoining of pre-mRNA regions for gene expression. ...This revelation offers new therapeutic oppo …
Pre-mRNA splicing factors recognize consensus signals within preliminary transcripts, and as cogs of the spliceosome machine, …
Pre-mRNA Splicing in the Nuclear Landscape.
Carrocci TJ, Neugebauer KM. Carrocci TJ, et al. Cold Spring Harb Symp Quant Biol. 2019;84:11-20. doi: 10.1101/sqb.2019.84.040402. Epub 2020 Jun 3. Cold Spring Harb Symp Quant Biol. 2019. PMID: 32493763 Free PMC article.
Eukaryotic gene expression requires the cumulative activity of multiple molecular machines to synthesize and process newly transcribed pre-messenger RNA. Introns, the noncoding regions in pre-mRNA, must be removed by the spliceosome, which assembles on the pre …
Eukaryotic gene expression requires the cumulative activity of multiple molecular machines to synthesize and process newly transcribed pre-m …
10,701 results
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