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Year Number of Results
2014 2
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2017 1
2018 14
2019 20
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2022 19
2023 10
2024 7

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Page 1
Olanzapine/Samidorphan: First Approval.
Paik J. Paik J. Drugs. 2021 Aug;81(12):1431-1436. doi: 10.1007/s40265-021-01568-0. Drugs. 2021. PMID: 34304374 Review.
Olanzapine/samidorphan (LYBALVI()) was recently approved in the USA for the treatment of schizophrenia and bipolar I disorder. This article summarizes the milestones in the development of samidorphan leading to this first approval of olanzapine/samidorphan... …
Olanzapine/samidorphan (LYBALVI()) was recently approved in the USA for the treatment of schizophrenia and bipolar I disorder. This a …
Olanzapine/Samidorphan: New Drug Approved for Treating Bipolar I Disorder and Schizophrenia.
Monahan C, McCoy L, Powell J, Gums JG. Monahan C, et al. Ann Pharmacother. 2022 Sep;56(9):1049-1057. doi: 10.1177/10600280211070330. Epub 2022 Jan 18. Ann Pharmacother. 2022. PMID: 35040357 Review.
OBJECTIVE: To describe the approval of olanzapine/samidorphan, compare the clinical trial data, and summarize key findings, with a focus on impact to clinical practice. ...Additional studies are needed to further define the role of olanzapine/samidorphan in bipolar …
OBJECTIVE: To describe the approval of olanzapine/samidorphan, compare the clinical trial data, and summarize key findings, with a fo …
Olanzapine/Samidorphan: A New Combination Treatment for Schizophrenia and Bipolar I Disorder Intended to Reduce Weight Gain.
Corrao MM, Nelson LA. Corrao MM, et al. CNS Drugs. 2022 Jun;36(6):605-616. doi: 10.1007/s40263-022-00923-3. Epub 2022 May 30. CNS Drugs. 2022. PMID: 35644903 Review.
The combination product olanzapine/samidorphan was approved by the US Food and Drug Administration in June 2021 for the treatment of schizophrenia and bipolar I disorder; this article reviews the pharmacological properties of oral olanzapine/samidorphan and its clin …
The combination product olanzapine/samidorphan was approved by the US Food and Drug Administration in June 2021 for the treatment of …
Combining samidorphan with olanzapine to mitigate weight gain as a side effect in schizophrenia treatment.
Grywińska WB, Głowacka A. Grywińska WB, et al. Postep Psychiatr Neurol. 2023 Sep;32(3):128-137. doi: 10.5114/ppn.2023.132493. Epub 2023 Nov 17. Postep Psychiatr Neurol. 2023. PMID: 38034507 Free PMC article. Review.
Studies have indicated that opioid receptor antagonists, such as samidorphan, have the potential to facilitate weight loss. Consequently, a novel therapy combining samidorphan and olanzapine has been developed and is discussed in detail in this article. ...Moreover, …
Studies have indicated that opioid receptor antagonists, such as samidorphan, have the potential to facilitate weight loss. Consequen …
Samidorphan/olanzapine combination therapy for schizophrenia: Efficacy, tolerance and adverse outcomes of regimen, evidence-based review of clinical trials.
Rehan ST, Siddiqui AH, Khan Z, Imran L, Syed AA, Tahir MJ, Jassani Z, Singh M, Asghar MS, Ahmed A. Rehan ST, et al. Ann Med Surg (Lond). 2022 Jun 30;79:104115. doi: 10.1016/j.amsu.2022.104115. eCollection 2022 Jul. Ann Med Surg (Lond). 2022. PMID: 35860157 Free PMC article. Review.
Recently, FDA approved a combination dose of olanzapine and samidorphan (OLZ/SAM) to mitigate the adverse outcomes associated with olanzapine use for the treatment of Schizophrenia. OBJECTIVES: The approval of olanzapine/samidorphan combination by FDA in treatment o …
Recently, FDA approved a combination dose of olanzapine and samidorphan (OLZ/SAM) to mitigate the adverse outcomes associated with ol …
Olanzapine/Samidorphan: A New Option for the Treatment of Adults With Schizophrenia or Bipolar I Disorder.
Pham H, Warlick H, Bermudez R, Nguyen Q, Rey JA. Pham H, et al. J Pharm Technol. 2022 Oct;38(5):304-313. doi: 10.1177/87551225221114281. Epub 2022 Jul 29. J Pharm Technol. 2022. PMID: 36046346 Free PMC article. Review.
OBJECTIVE: To review the pharmacology, pharmacokinetics, and efficacy and safety data of a combination of olanzapine and samidorphan (OLZ/SAM) for the treatment of schizophrenia and bipolar I disorder, which mitigates the possible unwanted side effects of weight gain assoc …
OBJECTIVE: To review the pharmacology, pharmacokinetics, and efficacy and safety data of a combination of olanzapine and samidorphan …
Olanzapine and samidorphan combination treatment: A systematic review.
Jawad MY, Alnefeesi Y, Lui LMW, Ceban F, Chen-Li DCJ, Teopiz K, Jaberi S, Gillissie ES, Vincenzo JDD, Rosenblat JD, McIntyre RS. Jawad MY, et al. J Affect Disord. 2022 Mar 15;301:99-106. doi: 10.1016/j.jad.2022.01.004. Epub 2022 Jan 7. J Affect Disord. 2022. PMID: 35007644 Review.
INTRODUCTION: The overarching aim of this review is to synthesize the efficacy, tolerability, and weight-mitigation effects of the olanzapine/samidorphan (OLZ/SAM) combination treatment in adults with schizophrenia and bipolar disorder-I. ...
INTRODUCTION: The overarching aim of this review is to synthesize the efficacy, tolerability, and weight-mitigation effects of the olanzapin …
A Review of Samidorphan: A Novel Opioid Antagonist.
Chaudhary AMD, Khan MF, Dhillon SS, Naveed S. Chaudhary AMD, et al. Cureus. 2019 Jul 15;11(7):e5139. doi: 10.7759/cureus.5139. Cureus. 2019. PMID: 31523568 Free PMC article. Review.
Opioid modulators have been explored as a treatment option for psychiatric disorders, but their use has been limited due to their abuse potential. Samidorphan (SAM), a mu-opioid receptor antagonist, has gained interest due to its favorable pharmacokinetic and pharmacodynam …
Opioid modulators have been explored as a treatment option for psychiatric disorders, but their use has been limited due to their abuse pote …
Olanzapine-samidorphan combination tablets for the treatment of schizophrenia and bipolar I disorder - what is it, and will it be used?
Faden J, Serdenes R, Citrome L. Faden J, et al. Expert Rev Neurother. 2022 May;22(5):365-376. doi: 10.1080/14737175.2022.2060742. Epub 2022 Apr 13. Expert Rev Neurother. 2022. PMID: 35354374 Review.
INTRODUCTION: Although olanzapine remains one of the most efficacious antipsychotic medications for the treatment of schizophrenia, there are significant tolerability concerns related to its weight and metabolic profile. Olanzapine-samidorphan combination tablets (OLZ/SAM) …
INTRODUCTION: Although olanzapine remains one of the most efficacious antipsychotic medications for the treatment of schizophrenia, there ar …
Olanzapine-Samidorphan for Schizophrenia: A Systematic Review and Meta-Analysis.
Gupta D, Singh A. Gupta D, et al. Indian J Psychol Med. 2024 Jan;46(1):14-23. doi: 10.1177/02537176231201326. Epub 2023 Oct 22. Indian J Psychol Med. 2024. PMID: 38524957 Free PMC article. Review.
BACKGROUND AND OBJECTIVE: United States Food and Drug Administration (USFDA) recently approved a novel combination of olanzapine-samidorphan (OLZSAM) for managing olanzapine-associated adverse events (weight gain) in adult patients with schizophrenia and bipolar disorder. …
BACKGROUND AND OBJECTIVE: United States Food and Drug Administration (USFDA) recently approved a novel combination of olanzapine-samidorp …
87 results