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New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV. Moorman AV. Haematologica. 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. Haematologica. 2016. PMID: 27033238 Free PMC article. Review.
Chromosomal abnormalities are used as diagnostic, prognostic and predictive biomarkers to provide subtype, outcome and drug response information. t(12;21)/ETV6-RUNX1 and high hyper-diploidy are good-risk prognostic biomarkers whereas KMT2A(MLL) translocations, t(17; …
Chromosomal abnormalities are used as diagnostic, prognostic and predictive biomarkers to provide subtype, outcome and drug response informa …
Translocation t(1;19)(q23;p13) in acute lymphoblastic leukemia. A report on six new cases and an unusual t(17;19)(q11;q13), with special reference to prognostic factors.
Laï JL, Fenaux P, Estienne MH, Huart JJ, Savary JB, Lepelley P, Jouet JP, Nelken B, Bauters F, Deminatti M. Laï JL, et al. Cancer Genet Cytogenet. 1989 Jan;37(1):9-17. doi: 10.1016/0165-4608(89)90068-x. Cancer Genet Cytogenet. 1989. PMID: 2917336
Intracytoplasmic immunoglobulins (cIg) were positive in the three cases where they were found. We also report on another patient, with a t(17;19) involving 17q11 and probably 19q13 regions, although involvement of 19p13 could not be excluded. ...
Intracytoplasmic immunoglobulins (cIg) were positive in the three cases where they were found. We also report on another patient, with a …
Adult precursor-B acute lymphoblastic leukemia with translocations involving chromosome band 19p13 is associated with poor prognosis.
Khalidi HS, O'Donnell MR, Slovak ML, Arber DA. Khalidi HS, et al. Cancer Genet Cytogenet. 1999 Feb;109(1):58-65. doi: 10.1016/s0165-4608(98)00153-8. Cancer Genet Cytogenet. 1999. PMID: 9973961
We studied the frequency, pathologic findings, and clinical course of adults with leukemia with 19p13 translocations. Six patients with t(1;19) (q23;p13) and one patient with t(17;19)(q21;p13), all with ALL, were identified over an 8-year period from among 18 …
We studied the frequency, pathologic findings, and clinical course of adults with leukemia with 19p13 translocations. Six patients with t(1; …
Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia.
Mathew S, Rao PH, Dalton J, Downing JR, Raimondi SC. Mathew S, et al. Leukemia. 2001 Mar;15(3):468-72. doi: 10.1038/sj.leu.2401989. Leukemia. 2001. PMID: 11237073
In two of the 20 patients (10%) with apparently normal karyotypes, SKY identified three cryptic translocations: a t(7;8)(q34-35;q24.1) in one patient and a t(13;17)(q22;q21) and a der(19)t(17;19)(q22;p13) in another. Fluorescence in situ hybridization using s …
In two of the 20 patients (10%) with apparently normal karyotypes, SKY identified three cryptic translocations: a t(7;8)(q34-35;q24.1) in on …
Distinct karyotypes in three breast cancer cell lines --21PTCi, 21NTCi, and 21MT-1 --derived from the same patient and representing different stages of tumor progression.
Xu J, Souter LH, Chambers AF, Rodenhiser DI, Tuck AB. Xu J, et al. Cancer Genet Cytogenet. 2008 Oct;186(1):33-40. doi: 10.1016/j.cancergencyto.2008.05.012. Cancer Genet Cytogenet. 2008. PMID: 18786440
The most common rearrangements differ in each cell line [i.e., der(X)t(X;3), der(4)t(1;4), del(6q) and der(19)t(17;19)(q11.2;q13.4) in 21PTCi; der(4)t(1;4), der(12)t(12;15) and -16 in 21NTCi; and der(1)t(1;10), +5, der(6)t(6;7), der(11)t(11;13), -20, and der( …
The most common rearrangements differ in each cell line [i.e., der(X)t(X;3), der(4)t(1;4), del(6q) and der(19)t(17;19)( …
Hypercalcemia and Disseminated Osteolytic Lesions With Normal Blood Counts and Absence of Circulating Blasts: A Rare Presentation of Childhood B-Lymphoblastic Leukemia.
Khayyam N, Mansoor N, Maqsood S, Jabbar N. Khayyam N, et al. J Pediatr Hematol Oncol. 2021 Mar 1;43(2):e301-e303. doi: 10.1097/MPH.0000000000001822. J Pediatr Hematol Oncol. 2021. PMID: 32404687
A review of the literature highlights the variable clinical outcome of this rare presentation depending on the presence of hypercalcemia and osteolytic lesions with or without chromosomal translocation t(17;19) and coagulation abnormalities. The patient had n …
A review of the literature highlights the variable clinical outcome of this rare presentation depending on the presence of hypercalcemia and …
Miller-Dieker syndrome. Detection of a cryptic chromosome translocation using in situ hybridization in a family with multiple affected offspring.
Alvarado M, Bass HN, Caldwell S, Jamehdor M, Miller AA, Jacob P. Alvarado M, et al. Am J Dis Child. 1993 Dec;147(12):1291-4. doi: 10.1001/archpedi.1993.02160360033012. Am J Dis Child. 1993. PMID: 8249946
As a result, a balanced cryptic translocation between chromosome 17 and chromosome 19 was identified in the father: 46,XY,t(17;19)(p13.3q13.33). An unbalanced form of the translocation, involving a deletion of 17p13.3, was detected with fluorescence in situ h …
As a result, a balanced cryptic translocation between chromosome 17 and chromosome 19 was identified in the father: 46,XY,t(17 …
Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child.
O'Meara E, Stack D, Phelan S, McDonagh N, Kelly L, Sciot R, Debiec-Rychter M, Morris T, Cochrane D, Sorensen P, O'Sullivan MJ. O'Meara E, et al. Genes Chromosomes Cancer. 2014 Dec;53(12):991-8. doi: 10.1002/gcc.22208. Epub 2014 Aug 19. Genes Chromosomes Cancer. 2014. PMID: 25139254
Undifferentiated spindle cell sarcoma (UDS) is a poorly defined or understood entity, essentially a waste-basket for cases failing to fulfill criteria for better-established diagnoses based on combined histology, immunohistochemistry, and tumor genetic assays. We identified a nov …
Undifferentiated spindle cell sarcoma (UDS) is a poorly defined or understood entity, essentially a waste-basket for cases failing to fulfil …