Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.
Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, Baillie R, Han X, Trojanowski JQ, Shaw LM, Martins R, Weiner MW, Trushina E, Toledo JB, Meikle PJ, Bennett DA, Krumsiek J, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Kastenmüller G.
Arnold M, et al.
Nat Commun. 2020 Mar 2;11(1):1148. doi: 10.1038/s41467-020-14959-w.
Nat Commun. 2020.
PMID: 32123170
Free PMC article.
Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE epsilon4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. ...Several group-specific metabolic alterations …
Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE epsilon4 genoty …