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Glioma epigenetics: From subclassification to novel treatment options.
Gusyatiner O, Hegi ME. Gusyatiner O, et al. Semin Cancer Biol. 2018 Aug;51:50-58. doi: 10.1016/j.semcancer.2017.11.010. Epub 2017 Nov 21. Semin Cancer Biol. 2018. PMID: 29170066 Review.
Gliomas are the most common malignant primary brain tumors, of which glioblastoma is the most malignant form (WHO grade IV), and notorious for treatment resistance. ...Most characteristic are mutations in IDH1 or IDH2 in lower grade gliomas, and histone 3 mutations in pedi …
Gliomas are the most common malignant primary brain tumors, of which glioblastoma is the most malignant form (WHO grade IV), and noto …
Treatment outcome and prognostic factors of adult glioblastoma multiforme.
Ahmadloo N, Kani AA, Mohammadianpanah M, Nasrolahi H, Omidvari S, Mosalaei A, Ansari M. Ahmadloo N, et al. J Egypt Natl Canc Inst. 2013 Mar;25(1):21-30. doi: 10.1016/j.jnci.2012.11.001. Epub 2012 Dec 21. J Egypt Natl Canc Inst. 2013. PMID: 23499203 Free article. Review.
INTRODUCTION: This study aimed to report the characteristics, prognostic factors and treatment outcome of 223 patients with glioblastoma multiforme (GBM). SUBJECTS AND METHOD: This retrospective study was carried out by reviewing the medical records of 223 adult pat …
INTRODUCTION: This study aimed to report the characteristics, prognostic factors and treatment outcome of 223 patients with glioblastoma …
Plasma PD-L1 as a biomarker in the clinical management of glioblastoma multiforme-a retrospective cohort study.
Masood AB, Batool S, Bhatti SN, Ali A, Valko M, Jomova K, Kuca K. Masood AB, et al. Front Immunol. 2023 Jul 17;14:1202098. doi: 10.3389/fimmu.2023.1202098. eCollection 2023. Front Immunol. 2023. PMID: 37529045 Free PMC article.
BACKGROUND AND OBJECTIVES: Glioblastoma multiforme (GBM) is the most aggressive, malignant, and therapy-resistant tumor of the brain. ...This study has quantified the plasma levels of PD-L1 as a biomarker for the clinical management of GBM. METHODS: A cohort (n = 12 …
BACKGROUND AND OBJECTIVES: Glioblastoma multiforme (GBM) is the most aggressive, malignant, and therapy-resistant tumor of the …
Biologic and immune modulating agents in the treatment of childhood brain tumors.
Packer RJ, Kramer ED, Ryan JA. Packer RJ, et al. Neurol Clin. 1991 May;9(2):405-22. Neurol Clin. 1991. PMID: 1944107 Review.
Given the limited alternatives for many of these patients, and the neurotoxicity of other means of therapy, future studies are clearly indicated in children with malignant brain tumors. The lack of evidence of efficacy in adult glioblastoma trials cannot be u …
Given the limited alternatives for many of these patients, and the neurotoxicity of other means of therapy, future studies are clearl …
Patient and treatment factors associated with survival among adult glioblastoma patients: A USA population-based study from 2000-2010.
Pan IW, Ferguson SD, Lam S. Pan IW, et al. J Clin Neurosci. 2015 Oct;22(10):1575-81. doi: 10.1016/j.jocn.2015.03.032. Epub 2015 Jun 26. J Clin Neurosci. 2015. PMID: 26122381
In this study, we utilized the USA surveillance, epidemiology, and end results (SEER) database to examine factors influencing survival of glioblastoma multiforme (GBM) patients. GBM is the most common primary malignant brain tumor in adults and despite advances in treatmen …
In this study, we utilized the USA surveillance, epidemiology, and end results (SEER) database to examine factors influencing survival of …
Serum IgE and Allergy Related Genotypes of IL-4R alpha and IL-13 Genes: Association with Glioma Susceptibility and Glioblastoma Prognosis.
Gohar MK, Ammar MG, Alnagar AA, Abd-ElAziz HA. Gohar MK, et al. Egypt J Immunol. 2018 Jan;25(1):19-33. Egypt J Immunol. 2018. PMID: 30242995
Gliomas are the commonest type of primary brain tumor in adult. Glioblastoma maltiforms (GBM) is the malignant form with poor prognosis. ...We also found that C allele of IL-13 is risk factor for glioma susceptibility with p value = 0.006. Longer median survival per …
Gliomas are the commonest type of primary brain tumor in adult. Glioblastoma maltiforms (GBM) is the malignant form with poor …
Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.
Keir ST, Dewhirst MW, Kirkpatrick JP, Bigner DD, Batinic-Haberle I. Keir ST, et al. Anticancer Agents Med Chem. 2011 Feb;11(2):202-12. doi: 10.2174/187152011795255957. Anticancer Agents Med Chem. 2011. PMID: 21291403 Free PMC article.
This study is the first report of the antitumor properties of MnTnHex-2-PyP(5+) as a single agent in adult and pediatric glioblastoma multiforme (D-54 MG, D-245 MG, D-256 MG, D-456 MG) and pediatric medulloblastoma (D-341 MED), and is the first case where a redox-ab …
This study is the first report of the antitumor properties of MnTnHex-2-PyP(5+) as a single agent in adult and pediatric glioblast …
VCF2CNA: A tool for efficiently detecting copy-number alterations in VCF genotype data and tumor purity.
Putnam DK, Ma X, Rice SV, Liu Y, Newman S, Zhang J, Chen X. Putnam DK, et al. Sci Rep. 2019 Jul 17;9(1):10357. doi: 10.1038/s41598-019-45938-x. Sci Rep. 2019. PMID: 31316100 Free PMC article.
It operates on whole genome and whole exome datasets. To benchmark its performance, we applied it to 46 adult glioblastoma and 146 pediatric neuroblastoma samples sequenced by Illumina and Complete Genomics (CGI) platforms respectively. VCF2CNA was highly consistent …
It operates on whole genome and whole exome datasets. To benchmark its performance, we applied it to 46 adult glioblastoma and …