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Page 1
Polyclonal hypergammaglobulinaemia: assessment, clinical interpretation, and management.
Zhao EJ, Cheng CV, Mattman A, Chen LYC. Zhao EJ, et al. Lancet Haematol. 2021 May;8(5):e365-e375. doi: 10.1016/S2352-3026(21)00056-9. Lancet Haematol. 2021. PMID: 33894171 Review.
Polyclonal hypergammaglobulinaemia is most commonly caused by liver disease, immune dysregulation, or inflammation, but can also provide an important diagnostic clue of rare diseases such as histiocyte disorders, autoimmune lymphoproliferative syndrome, Castl …
Polyclonal hypergammaglobulinaemia is most commonly caused by liver disease, immune dysregulation, or inflammation, but can also provide an …
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.
Oliveira JB, Bleesing JJ, Dianzani U, Fleisher TA, Jaffe ES, Lenardo MJ, Rieux-Laucat F, Siegel RM, Su HC, Teachey DT, Rao VK. Oliveira JB, et al. Blood. 2010 Oct 7;116(14):e35-40. doi: 10.1182/blood-2010-04-280347. Epub 2010 Jun 10. Blood. 2010. PMID: 20538792 Free PMC article.
Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in an accumula …
Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. A …
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management.
López-Nevado M, González-Granado LI, Ruiz-García R, Pleguezuelo D, Cabrera-Marante O, Salmón N, Blanco-Lobo P, Domínguez-Pinilla N, Rodríguez-Pena R, Sebastián E, Cruz-Rojo J, Olbrich P, Ruiz-Contreras J, Paz-Artal E, Neth O, Allende LM. López-Nevado M, et al. Front Immunol. 2021 Aug 10;12:671755. doi: 10.3389/fimmu.2021.671755. eCollection 2021. Front Immunol. 2021. PMID: 34447369 Free PMC article.
Primary immune regulatory disorders (PIRD) are associated with autoimmunity, autoinflammation and/or dysregulation of lymphocyte homeostasis. Autoimmune lymphoproliferative syndrome (ALPS) is a PIRD due to an apoptotic defect in Fas-FasL pathway and character …
Primary immune regulatory disorders (PIRD) are associated with autoimmunity, autoinflammation and/or dysregulation of lymphocyte homeostasis …
Optimal Management of Autoimmune Lymphoproliferative Syndrome in Children.
George LA, Teachey DT. George LA, et al. Paediatr Drugs. 2016 Aug;18(4):261-72. doi: 10.1007/s40272-016-0175-3. Paediatr Drugs. 2016. PMID: 27139496 Free PMC article. Review.
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte homeostasis, resulting from mutations in the Fas apoptotic pathway. ...Sirolimus and mycophenolate mofetil are the best-studied and most effective corticosteroid-sparing th …
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte homeostasis, resulting from mutatio …
Diagnosis and management of autoimmune cytopenias in childhood.
Teachey DT, Lambert MP. Teachey DT, et al. Pediatr Clin North Am. 2013 Dec;60(6):1489-511. doi: 10.1016/j.pcl.2013.08.009. Epub 2013 Oct 5. Pediatr Clin North Am. 2013. PMID: 24237984 Free PMC article. Review.
The diagnosis and management of children with autoimmune cytopenias can be challenging. Children can present with immune-mediated destruction of a single-cell lineage or multiple cell lineages, including platelets (immune thrombocytopenia [ITP]), erythrocytes (autoimmun …
The diagnosis and management of children with autoimmune cytopenias can be challenging. Children can present with immune-mediated des …
Genomics Driving Diagnosis and Treatment of Inborn Errors of Immunity With Cancer Predisposition.
Barmettler S, Sharapova SO, Milota T, Greif PA, Magg T, Hauck F. Barmettler S, et al. J Allergy Clin Immunol Pract. 2022 Jul;10(7):1725-1736.e2. doi: 10.1016/j.jaip.2022.03.012. Epub 2022 Mar 29. J Allergy Clin Immunol Pract. 2022. PMID: 35364342 Review.
However, broad application of unbiased genetics in these neighboring disciplines still needs to be deployed, and joined therapeutic strategies guided by germline and somatic genetic risk factors are lacking. We illustrate the current difficulties encountered in clinical pr …
However, broad application of unbiased genetics in these neighboring disciplines still needs to be deployed, and joined therapeutic s …
Advances in the management and understanding of autoimmune lymphoproliferative syndrome (ALPS).
Teachey DT, Seif AE, Grupp SA. Teachey DT, et al. Br J Haematol. 2010 Jan;148(2):205-16. doi: 10.1111/j.1365-2141.2009.07991.x. Epub 2009 Nov 23. Br J Haematol. 2010. PMID: 19930184 Free PMC article. Review.
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of T cell dysregulation caused by defective Fas-mediated apoptosis. ...As the pathophysiology of ALPS is better characterized, a number of targeted therapies are in preclinical development an …
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of T cell dysregulation caused by defective Fas-mediated a …
Autoimmune lymphoproliferative syndrome: etiology, diagnosis, and management.
van der Werff ten Bosch J. van der Werff ten Bosch J. Paediatr Drugs. 2003;5(3):185-93. doi: 10.2165/00128072-200305030-00005. Paediatr Drugs. 2003. PMID: 12608883 Review.
Autoimmune lymphoproliferative syndrome (ALPS) is a childhood disorder characterized by chronic, nonmalignant lymphoproliferation and autoimmunity, most commonly involving cells of hematopoietic origin. ...Although the syndrome has a benign nature, lif …
Autoimmune lymphoproliferative syndrome (ALPS) is a childhood disorder characterized by chronic, nonmalignant lymphopro …
New advances in the diagnosis and treatment of autoimmune lymphoproliferative syndrome.
Teachey DT. Teachey DT. Curr Opin Pediatr. 2012 Feb;24(1):1-8. doi: 10.1097/MOP.0b013e32834ea739. Curr Opin Pediatr. 2012. PMID: 22157362 Free PMC article. Review.
PURPOSE OF REVIEW: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of disrupted lymphocyte homeostasis, resulting from mutations in the Fas apoptotic pathway. Clinical manifestations include lymphadenopathy, splenomegaly, and autoimmune cy …
PURPOSE OF REVIEW: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of disrupted lymphocyte homeostasis, re …
Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS).
Casamayor-Polo L, López-Nevado M, Paz-Artal E, Anel A, Rieux-Laucat F, Allende LM. Casamayor-Polo L, et al. Crit Rev Clin Lab Sci. 2021 Jun;58(4):253-274. doi: 10.1080/10408363.2020.1855623. Epub 2020 Dec 23. Crit Rev Clin Lab Sci. 2021. PMID: 33356695
In the last 25 years, inherited human diseases of the Fas-FasL pathway have been recognized. Autoimmune lymphoproliferative syndrome (ALPS) is an inborn error of immunity, characterized clinically by nonmalignant and noninfectious lymphoproliferation, autoimm …
In the last 25 years, inherited human diseases of the Fas-FasL pathway have been recognized. Autoimmune lymphoproliferative …
17 results