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Page 1
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.
Hwang EI, Hanson D, Filbin MG, Mack SC. Hwang EI, et al. Neoplasia. 2023 May;39:100895. doi: 10.1016/j.neo.2023.100895. Epub 2023 Mar 20. Neoplasia. 2023. PMID: 36944298 Free PMC article.
Pediatric intracranial ependymoma has seen a recent exponential expansion of biological findings, rapidly dividing the diagnosis into several subgroups, each with specific molecular and clinical characteristics. While such subdivision may complicate clinical conclusions fr …
Pediatric intracranial ependymoma has seen a recent exponential expansion of biological findings, rapidly dividing the diagnosis into …
Childhood ependymoma: a systematic review of treatment options and strategies.
Grill J, Pascal C, Chantal K. Grill J, et al. Paediatr Drugs. 2003;5(8):533-43. doi: 10.2165/00148581-200305080-00004. Paediatr Drugs. 2003. PMID: 12895136 Review.
Childhood intracranial ependymoma have a dismal prognosis, especially in young children and when a gross total resection cannot be performed. ...In this respect, hyperfractionation or radiosensitizers may be valuable therapeutic options. The treatment of chil …
Childhood intracranial ependymoma have a dismal prognosis, especially in young children and when a gross total resection canno …
Timing of adjuvant radiotherapy and treatment outcome in childhood ependymoma.
Liu AP, Shing MM, Yuen HL, Li CH, Ling SC, Luk CW, Ha SY, Li CK, Kwong DL, Chan GC. Liu AP, et al. Pediatr Blood Cancer. 2014 Apr;61(4):606-11. doi: 10.1002/pbc.24820. Epub 2013 Oct 26. Pediatr Blood Cancer. 2014. PMID: 24167035
BACKGROUND: Several trials incorporating adjuvant focal RT for treatment of young children with ependymoma have demonstrated improved survival with acceptable adverse effects. ...RESULTS: Thirty-one patients with intracranial ependymoma were identified. Median age w …
BACKGROUND: Several trials incorporating adjuvant focal RT for treatment of young children with ependymoma have demonstrated improved …
Current management of childhood ependymoma.
Merchant TE. Merchant TE. Oncology (Williston Park). 2002 May;16(5):629-42, 644; discussion 645-6, 648. Oncology (Williston Park). 2002. PMID: 12108890 Free article. Review.
Radiation therapy has long been a mainstay in the treatment of ependymoma. Concerns about the long-term effects of radiation therapy have made many parents and caregivers wary of this treatment modality. However, with the advent of conformal radiation and evi …
Radiation therapy has long been a mainstay in the treatment of ependymoma. Concerns about the long-term effects of radiation …
Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment.
Massimino M, Giangaspero F, Garrè ML, Genitori L, Perilongo G, Collini P, Riva D, Valentini L, Scarzello G, Poggi G, Spreafico F, Peretta P, Mascarin M, Modena P, Sozzi G, Bedini N, Biassoni V, Urgesi A, Balestrini MR, Finocchiaro G, Sandri A, Gandola L; AIEOP Neuro-Oncology Group. Massimino M, et al. Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1440-5. doi: 10.1016/j.ijrobp.2006.03.052. Int J Radiat Oncol Biol Phys. 2006. PMID: 16863927
PURPOSE: To discuss the results obtained by giving adjuvant treatment for childhood ependymoma (EPD) at relapse after complete surgery only. ...
PURPOSE: To discuss the results obtained by giving adjuvant treatment for childhood ependymoma (EPD) at relapse after complete …
The history of ependymoma management.
Shim KW, Kim DS, Choi JU. Shim KW, et al. Childs Nerv Syst. 2009 Oct;25(10):1167-83. doi: 10.1007/s00381-009-0900-0. Epub 2009 May 21. Childs Nerv Syst. 2009. PMID: 19458954
RADIATION THERAPY: Radiation treatment has been the option for disseminated disease and residual tumor. ...The history of ependymoma management is still in progress....
RADIATION THERAPY: Radiation treatment has been the option for disseminated disease and residual tumor. ...The history of ependymo …
Adjunctive treatment for recurrent childhood ependymoma of the IV ventricle: chemotherapy with CDDP and MCNU.
Tamura M, Ono N, Kurihara H, Ohye C, Miyazaki M. Tamura M, et al. Childs Nerv Syst. 1990 Jun;6(4):186-9. doi: 10.1007/BF01850968. Childs Nerv Syst. 1990. PMID: 2383872
The prognosis of recurrent IV-ventricle ependymoma in children is poor. Three cases of recurrent ependymoma were treated with combination chemotherapy using cis-diamine dichloro platinum (II) (CDDP) and methyl-6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-alpha-D-gl …
The prognosis of recurrent IV-ventricle ependymoma in children is poor. Three cases of recurrent ependymoma were treated with …
New chemotherapy strategies and biological agents in the treatment of childhood ependymoma.
Wright KD, Gajjar A. Wright KD, et al. Childs Nerv Syst. 2009 Oct;25(10):1275-82. doi: 10.1007/s00381-009-0809-7. Epub 2009 Feb 11. Childs Nerv Syst. 2009. PMID: 19212772 Free PMC article.
INTRODUCTION: With the limited role of current treatment regimens and potential associated side effects of radiation in young children with ependymoma, considerable effort is being focused on new chemotherapeutic strategies and biologic agents. DISCUSSION AND CONCLUSION: I …
INTRODUCTION: With the limited role of current treatment regimens and potential associated side effects of radiation in young children with …
Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice.
Badruddoja MA, Keir ST, King I, Zeidner J, Vredenburgh JJ, Muhlbaier LH, Bigner DD, Friedman HS. Badruddoja MA, et al. Neuro Oncol. 2007 Jul;9(3):240-4. doi: 10.1215/15228517-2007-011. Epub 2007 May 23. Neuro Oncol. 2007. PMID: 17522334 Free PMC article.

The results demonstrated statistically significant (p < 0.05) growth delays of 15.0, 8.3, 51.0, 60+, 60+, and 60+ days in subcutaneous xenografts derived from childhood glioblastoma multiforme (D-456 MG), childhood ependymoma (D-528 EP and D-612 EP), ch

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The results demonstrated statistically significant (p < 0.05) growth delays of 15.0, 8.3, 51.0, 60+, 60+, and 60+ days in subcutaneous xe

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