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Treatment potential in APOL1-associated nephropathy.
Friedman DJ, Ma L, Freedman BI. Friedman DJ, et al. Curr Opin Nephrol Hypertens. 2022 Sep 1;31(5):442-448. doi: 10.1097/MNH.0000000000000816. Epub 2022 Jul 11. Curr Opin Nephrol Hypertens. 2022. PMID: 35894278 Review.
RECENT FINDINGS: Since the 2010 discovery of APOL1 as a cause of nondiabetic nephropathy in individuals with sub-Saharan African ancestry, it has become apparent that aggressive hypertension control, renin-angiotensin system blockade, steroids and conventional immunosuppressive a …
RECENT FINDINGS: Since the 2010 discovery of APOL1 as a cause of nondiabetic nephropathy in individuals with sub-Saharan African ancestry, i …
HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment.
Rosenberg AZ, Naicker S, Winkler CA, Kopp JB. Rosenberg AZ, et al. Nat Rev Nephrol. 2015 Mar;11(3):150-60. doi: 10.1038/nrneph.2015.9. Epub 2015 Feb 17. Nat Rev Nephrol. 2015. PMID: 25686569 Review.
HIV is a highly adaptive, rapidly evolving virus, which is associated with renal diseases including collapsing glomerulopathy-the classic histomorphological form of HIV-associated nephropathy. ...The mechanisms responsible for HIVAN, including HIV infection of podoc …
HIV is a highly adaptive, rapidly evolving virus, which is associated with renal diseases including collapsing glomerulopathy- …
Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population.
Neves PD, Watanabe A, Watanabe EH, Narcizo AM, Nunes K, Lerario AM, Ferreira FM, Cavalcante LB, Wongboonsin J, Malheiros DM, Jorge LB, Sampson MG, Noronha IL, Onuchic LF. Neves PD, et al. Kidney Int. 2024 Mar;105(3):593-607. doi: 10.1016/j.kint.2023.11.028. Epub 2023 Dec 22. Kidney Int. 2024. PMID: 38143038
Collapsing glomerulopathy (CG) is most often associated with fast progression to kidney failure with an incidence apparently higher in Brazil than in other countries. ...To better understand this, we performed an integrated analysis of clinical, histological, the …
Collapsing glomerulopathy (CG) is most often associated with fast progression to kidney failure with an incidence apparently h …
AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL 1 High-Risk Genotype.
Wu H, Larsen CP, Hernandez-Arroyo CF, Mohamed MMB, Caza T, Sharshir M, Chughtai A, Xie L, Gimenez JM, Sandow TA, Lusco MA, Yang H, Acheampong E, Rosales IA, Colvin RB, Fogo AB, Velez JCQ. Wu H, et al. J Am Soc Nephrol. 2020 Aug;31(8):1688-1695. doi: 10.1681/ASN.2020050558. Epub 2020 Jun 19. J Am Soc Nephrol. 2020. PMID: 32561682 Free PMC article.
At biopsy day, mean serum creatinine was 6.5 mg/dl and mean urine protein-creatinine ratio was 11.5 g. Kidney biopsy specimens showed collapsing glomerulopathy, extensive foot process effacement, and focal/diffuse acute tubular injury. ...Five patients needed dialys …
At biopsy day, mean serum creatinine was 6.5 mg/dl and mean urine protein-creatinine ratio was 11.5 g. Kidney biopsy specimens showed col …
MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
Kopp JB, Winkler CA, Nelson GW. Kopp JB, et al. Semin Nephrol. 2010 Jul;30(4):409-17. doi: 10.1016/j.semnephrol.2010.06.007. Semin Nephrol. 2010. PMID: 20807613 Free PMC article.
Disease associations include human immunodeficiency virus-associated collapsing glomerulopathy, focal segmental glomerulosclerosis, hypertension-attributed end-stage kidney disease, and diabetes-attributed end-stage kidney disease. ...Such studies will address criti …
Disease associations include human immunodeficiency virus-associated collapsing glomerulopathy, focal segmental glomeruloscler …
Adult onset Still's disease and collapsing glomerulopathy: successful treatment with intravenous immunoglobulins and mycophenolate mofetil.
Bennett AN, Peterson P, Sangle S, Hangartner R, Abbs IC, Hughes GR, D'Cruz DP. Bennett AN, et al. Rheumatology (Oxford). 2004 Jun;43(6):795-9. doi: 10.1093/rheumatology/keh172. Epub 2004 Mar 23. Rheumatology (Oxford). 2004. PMID: 15039497
Primary infection and lymphoma were excluded and he was treated, with dramatic success, with intravenous immunoglobulins (i.v.IG). Subsequent renal biopsy excluded SLE but confirmed collapsing glomerulopathy. The proteinuria improved dramatically following treatment …
Primary infection and lymphoma were excluded and he was treated, with dramatic success, with intravenous immunoglobulins (i.v.IG). Subsequen …
Donor APOL1 high-risk genotypes are associated with increased risk and inferior prognosis of de novo collapsing glomerulopathy in renal allografts.
Santoriello D, Husain SA, De Serres SA, Bomback AS, Crew RJ, Vasilescu ER, Serban G, Campenot ES, Kiryluk K, Mohan S, Hawkins GA, Hicks PJ, Cohen DJ, Radhakrishnan J, Stokes MB, Markowitz GS, Freedman BI, D'Agati VD, Batal I. Santoriello D, et al. Kidney Int. 2018 Dec;94(6):1189-1198. doi: 10.1016/j.kint.2018.06.024. Epub 2018 Oct 2. Kidney Int. 2018. PMID: 30287079 Free PMC article.
Collapsing focal segmental glomerulosclerosis (cFSGS) in the native kidney is associated with heavy proteinuria and accelerated renal failure. ...
Collapsing focal segmental glomerulosclerosis (cFSGS) in the native kidney is associated with heavy proteinuria and accelerated renal …
HIV-associated renal disorders: recent insights into pathogenesis and treatment.
Berggren R, Batuman V. Berggren R, et al. Curr HIV/AIDS Rep. 2005 Aug;2(3):109-15. doi: 10.1007/s11904-005-0002-x. Curr HIV/AIDS Rep. 2005. PMID: 16091256 Review.
Glomerular disorders include IgA nephropathy, cryoglobulinemia, amyloidosis, and a lupus-like immune complex glomerulopathy. The most attention has been focused on collapsing glomerulopathy associated with nephrotic syndrome and progressive renal failure, whi …
Glomerular disorders include IgA nephropathy, cryoglobulinemia, amyloidosis, and a lupus-like immune complex glomerulopathy. The most …
CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases.
Soos TJ, Meijer L, Nelson PJ. Soos TJ, et al. Drug News Perspect. 2006 Jul-Aug;19(6):325-8. doi: 10.1358/dnp.2006.19.6.985939. Drug News Perspect. 2006. PMID: 16971968 Free article. Review.
Given the central role that both cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) play in promoting aberrant proliferation within the kidney, these paralogous serine/threonine kinases are being explored as therapeutic molecular targets in proliferativ …
Given the central role that both cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) play in promoting aberrant prolifera …