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Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer.
Memari E, Khan D, Alkins R, Helfield B. Memari E, et al. J Control Release. 2024 Mar;367:283-299. doi: 10.1016/j.jconrel.2024.01.034. Epub 2024 Jan 29. J Control Release. 2024. PMID: 38266715 Review.
Focused ultrasound (FUS) combined with intravascularly circulating microbubbles can transiently increase the permeability of the blood-brain barrier (BBB) to enable targeted therapeutic delivery to the brain, the clinical testing of which is currently underway in bo …
Focused ultrasound (FUS) combined with intravascularly circulating microbubbles can transiently increase the permeability of t …
Real-time spatiotemporal characterization of mechanics and sonoporation of acoustic droplet vaporization in acoustically responsive scaffolds.
Aliabouzar M, Abeid BA, Kripfgans OD, Fowlkes JB, Estrada JB, Fabiilli ML. Aliabouzar M, et al. Appl Phys Lett. 2023 Sep 11;123(11):114101. doi: 10.1063/5.0159661. Appl Phys Lett. 2023. PMID: 37705893
Phase-shift droplets provide a flexible and dynamic platform for therapeutic and diagnostic applications of ultrasound. The spatiotemporal response of phase-shift droplets to focused ultrasound, via the mechanism termed acoustic droplet vaporization (ADV), ca …
Phase-shift droplets provide a flexible and dynamic platform for therapeutic and diagnostic applications of ultrasound. The spatiotem …
Improved Therapeutic Delivery Targeting Clinically Relevant Orthotopic Human Pancreatic Tumors Engrafted in Immunocompromised Pigs Using Ultrasound-Induced Cavitation: A Pilot Study.
Imran KM, Tintera B, Morrison HA, Tupik JD, Nagai-Singer MA, Ivester H, Council-Troche M, Edwards M, Coutermarsh-Ott S, Byron C, Clark-Deener S, Uh K, Lee K, Boulos P, Rowe C, Coviello C, Allen IC. Imran KM, et al. Pharmaceutics. 2023 May 24;15(6):1585. doi: 10.3390/pharmaceutics15061585. Pharmaceutics. 2023. PMID: 37376034 Free PMC article.
Animals were intravenously injected with the common cancer therapeutics Cetuximab, gemcitabine, and paclitaxel, followed by infusion with SonoTran Particles. Select tumors in each animal were targeted with focused ultrasound to induce cavitation. Cavitation increase …
Animals were intravenously injected with the common cancer therapeutics Cetuximab, gemcitabine, and paclitaxel, followed by infusion with So …
Ultrasound-induced cavitation renders prostate cancer cells susceptible to hyperthermia: Analysis of potential cellular and molecular mechanisms.
Hu S, Zhang X, Melzer A, Landgraf L. Hu S, et al. Front Genet. 2023 Apr 19;14:1122758. doi: 10.3389/fgene.2023.1122758. eCollection 2023. Front Genet. 2023. PMID: 37152995 Free PMC article.
Background: Focused ultrasound (FUS) has become an important non-invasive therapy for prostate tumor ablation via thermal effects in the clinic. The cavitation effect induced by FUS is applied for histotripsy, support drug delivery, and the induction of blood …
Background: Focused ultrasound (FUS) has become an important non-invasive therapy for prostate tumor ablation via therm …
Nonspherical ultrasound microbubbles.
Dasgupta A, Sun T, Palomba R, Rama E, Zhang Y, Power C, Moeckel D, Liu M, Sarode A, Weiler M, Motta A, Porte C, Magnuska Z, Said Elshafei A, Barmin R, Graham A, McClelland A, Rommel D, Stickeler E, Kiessling F, Pallares RM, De Laporte L, Decuzzi P, McDannold N, Mitragotri S, Lammers T. Dasgupta A, et al. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2218847120. doi: 10.1073/pnas.2218847120. Epub 2023 Mar 20. Proc Natl Acad Sci U S A. 2023. PMID: 36940339 Free PMC article.
Compared to their spherical counterparts, nonspherical polymeric MB displayed superior performance in multiple ways, including i) increased margination behavior in blood vessel-like flow chambers, ii) reduced macrophage uptake in vitro, iii) prolonged circulation time in vivo, an …
Compared to their spherical counterparts, nonspherical polymeric MB displayed superior performance in multiple ways, including i) increased …
Barrier-breaking effects of ultrasonic cavitation for drug delivery and biomarker release.
Hu Y, Wei J, Shen Y, Chen S, Chen X. Hu Y, et al. Ultrason Sonochem. 2023 Mar;94:106346. doi: 10.1016/j.ultsonch.2023.106346. Epub 2023 Feb 26. Ultrason Sonochem. 2023. PMID: 36870921 Free PMC article.
To promote the barrier-breaking effects of cavitation for both therapy and diagnosis, we first reviewed recent technical advances of ultrasound and its contrast agents (microbubbles, nanodroplets, and gas-stabilizing nanoparticles) and then reported the newly-revealed cavi …
To promote the barrier-breaking effects of cavitation for both therapy and diagnosis, we first reviewed recent technical advances of ultr …
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors.
Haram M, Snipstad S, Berg S, Mjønes P, Rønne E, Lage J, Mühlenpfordt M, Davies CL. Haram M, et al. Ultrasound Med Biol. 2023 May;49(5):1275-1287. doi: 10.1016/j.ultrasmedbio.2023.01.014. Epub 2023 Feb 25. Ultrasound Med Biol. 2023. PMID: 36842903 Free article.
Results so far are promising, but without clinical impact. Our aim was to investigate whether ultrasound and microbubbles could improve the uptake and therapeutic response of conventional chemotherapy. METHODS: Orthotopic pancreatic tumors growing in mice were treated with …
Results so far are promising, but without clinical impact. Our aim was to investigate whether ultrasound and microbubbles could impro …
Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response.
Do HD, Marie C, Bessoles S, Dhotel H, Seguin J, Larrat B, Doan BT, Scherman D, Escriou V, Hacein-Bey-Abina S, Mignet N. Do HD, et al. Explor Target Antitumor Ther. 2022;3(6):398-413. doi: 10.37349/etat.2022.00090. Epub 2022 Jun 29. Explor Target Antitumor Ther. 2022. PMID: 36046055 Free PMC article.
Here, IL-12 encoding plasmid, non-viral carrier stimulating the immune response and focused ultrasound were combined in order to improve the antitumoral efficiency. METHODS: In order to enhance a gene-based antitumoral immune response, home-made lipids Toll-like rec …
Here, IL-12 encoding plasmid, non-viral carrier stimulating the immune response and focused ultrasound were combined in order …
Development of and Gathering Validity Evidence for a Theoretical Test in Contrast-Enhanced Ultrasound.
Jacobsen N, Nolsøe CP, Konge L, Graumann O, Dietrich CF, Sidhu PS, Gilja OH, Meloni MF, Berzigotti A, Harvey CJ, Deganello A, Prada F, Lerchbaumer MH, Laursen CB. Jacobsen N, et al. Ultrasound Med Biol. 2022 Feb;48(2):248-256. doi: 10.1016/j.ultrasmedbio.2021.10.016. Epub 2021 Nov 21. Ultrasound Med Biol. 2022. PMID: 34815128 Free article.
Contrast-enhanced ultrasound (CEUS) is an imaging modality applied in a broad field of medical specialties for diagnostic uses, guidance during biopsy procedures and ablation therapies and sonoporation therapy. ...
Contrast-enhanced ultrasound (CEUS) is an imaging modality applied in a broad field of medical specialties for diagnostic uses, guida …
High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications.
Bachu VS, Kedda J, Suk I, Green JJ, Tyler B. Bachu VS, et al. Ann Biomed Eng. 2021 Sep;49(9):1975-1991. doi: 10.1007/s10439-021-02833-9. Epub 2021 Aug 10. Ann Biomed Eng. 2021. PMID: 34374945 Free PMC article. Review.
High Intensity Focused Ultrasound (HIFU) is an emerging and increasingly useful modality in the treatment of cancer and other diseases. Although traditional use of ultrasound at lower frequencies has primarily been for diagnostic imaging …
High Intensity Focused Ultrasound (HIFU) is an emerging and increasingly useful modality in the treatment …
56 results