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Page 1
The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline.
Brown RJ, Araujo-Vilar D, Cheung PT, Dunger D, Garg A, Jack M, Mungai L, Oral EA, Patni N, Rother KI, von Schnurbein J, Sorkina E, Stanley T, Vigouroux C, Wabitsch M, Williams R, Yorifuji T. Brown RJ, et al. J Clin Endocrinol Metab. 2016 Dec;101(12):4500-4511. doi: 10.1210/jc.2016-2466. Epub 2016 Oct 6. J Clin Endocrinol Metab. 2016. PMID: 27710244 Free PMC article. Review.
This practice guideline summarizes the diagnosis and management of lipodystrophy syndromes not associated with HIV or injectable drugs. ...Diet is essential for the management of metabolic complications of lipodystrophy. Metreleptin therapy is effective for m …
This practice guideline summarizes the diagnosis and management of lipodystrophy syndromes not associated with HIV or injectable drug …
Diagnosis and treatment of lipodystrophy: a step-by-step approach.
Araújo-Vilar D, Santini F. Araújo-Vilar D, et al. J Endocrinol Invest. 2019 Jan;42(1):61-73. doi: 10.1007/s40618-018-0887-z. Epub 2018 Apr 27. J Endocrinol Invest. 2019. PMID: 29704234 Free PMC article. Review.
Leptin replacement therapy (metreleptin) has been found to improve metabolic parameters in many patients with lipodystrophy. Metreleptin is approved in the United States as replacement therapy to treat the complications of leptin deficiency in patients with c …
Leptin replacement therapy (metreleptin) has been found to improve metabolic parameters in many patients with lipodystrophy. M …
Treatment Options for Lipodystrophy in Children.
Mainieri F, Tagi VM, Chiarelli F. Mainieri F, et al. Front Endocrinol (Lausanne). 2022 May 4;13:879979. doi: 10.3389/fendo.2022.879979. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35600578 Free PMC article. Review.
Given the evidence of leptin deficiency in lipodystrophy syndromes, leptin replacement therapy has been considered as a treatment option. ...Recently, metreleptin was approved by Food and Drug Administration (FDA) for the treatment of generalized lipodystr …
Given the evidence of leptin deficiency in lipodystrophy syndromes, leptin replacement therapy has been considered as a treatm …
Clinical Features and Management of Non-HIV-Related Lipodystrophy in Children: A Systematic Review.
Gupta N, Asi N, Farah W, Almasri J, Barrionuevo P, Alsawas M, Wang Z, Haymond MW, Brown RJ, Murad MH. Gupta N, et al. J Clin Endocrinol Metab. 2017 Feb 1;102(2):363-374. doi: 10.1210/jc.2016-2271. J Clin Endocrinol Metab. 2017. PMID: 27967300 Free PMC article. Review.
CONTEXT: Lipodystrophy syndromes are characterized by generalized or partial absence of adipose tissue. ...Generalized fat loss involving face, neck, abdomen, thorax, and upper and lower limbs was explicitly reported in 65% to 93% of patients with congenital …
CONTEXT: Lipodystrophy syndromes are characterized by generalized or partial absence of adipose tissue. ...Generalized …
Metreleptin Treatment in Patients with Non-HIV Associated Lipodystrophy.
Akinci G, Akinci B. Akinci G, et al. Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):74-8. doi: 10.2174/1574892811666151111142554. Recent Pat Endocr Metab Immune Drug Discov. 2015. PMID: 26556498 Review.
Recently, metreleptin, a recombinant human leptin analog, has been approved for the treatment of patients with generalized lipodystrophy. Leptin is an adipokine which has a fundamental role in glucose and lipid homeostasis. Metreleptin treatment has been demonstrate …
Recently, metreleptin, a recombinant human leptin analog, has been approved for the treatment of patients with generalized lipodys …
Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.
Brown RJ, Oral EA, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Gorden P. Brown RJ, et al. Endocrine. 2018 Jun;60(3):479-489. doi: 10.1007/s12020-018-1589-1. Epub 2018 Apr 12. Endocrine. 2018. PMID: 29644599 Free PMC article.
PURPOSE: The purpose of this study is to summarize the effectiveness and safety of metreleptin in patients with congenital or acquired generalized lipodystrophy. METHODS: Patients (n = 66) aged 6 months had lipodystrophy, low circulating leptin, and 1 metabol …
PURPOSE: The purpose of this study is to summarize the effectiveness and safety of metreleptin in patients with congenital or acquired ge …
Genetic basis of lipodystrophies and management of metabolic complications.
Agarwal AK, Garg A. Agarwal AK, et al. Annu Rev Med. 2006;57:297-311. doi: 10.1146/annurev.med.57.022605.114424. Annu Rev Med. 2006. PMID: 16409151 Review.
Among genetic lipodystrophies, fat loss is observed either from birth, as in congenital generalized lipodystrophy, or later in life, as in familial partial lipodystrophy. ...We discuss features of autosomal recessive and dominant types of lipodystrophies and …
Among genetic lipodystrophies, fat loss is observed either from birth, as in congenital generalized lipodystrophy, or later in …
Facial soft tissue volume decreases during metreleptin treatment in patients with partial and generalized lipodystrophy.
Miehle K, Stumvoll M, Fasshauer M, Hierl T. Miehle K, et al. Endocrine. 2017 Nov;58(2):262-266. doi: 10.1007/s12020-017-1437-8. Epub 2017 Oct 9. Endocrine. 2017. PMID: 28993984
The effect of recombinant leptin (metreleptin) therapy on facial soft tissue volume in patients with non-human immunodeficiency virus LD has not been quantified to date. ...Five of the six patients with FPLD lost between 4 and 114 cm(3) of facial soft tissue volume in the …
The effect of recombinant leptin (metreleptin) therapy on facial soft tissue volume in patients with non-human immunodeficiency virus …
Mandibuloacral dysplasia type B (MADB): a cohort of eight patients from Suriname with a homozygous founder mutation in ZMPSTE24 (FACE1), clinical diagnostic criteria and management guidelines.
Hitzert MM, van der Crabben SN, Baldewsingh G, van Amstel HKP, van den Wijngaard A, van Ravenswaaij-Arts CMA, Zijlmans CWR. Hitzert MM, et al. Orphanet J Rare Dis. 2019 Dec 19;14(1):294. doi: 10.1186/s13023-019-1269-0. Orphanet J Rare Dis. 2019. PMID: 31856865 Free PMC article.
BACKGROUND: Mandibuloacral Dysplasia with type B lipodystrophy (MADB) is a rare premature aging disorder with an autosomal recessive inheritance pattern. MADB is characterized by brittle hair, mottled, atrophic skin, generalized lipodystrophy, insulin resista …
BACKGROUND: Mandibuloacral Dysplasia with type B lipodystrophy (MADB) is a rare premature aging disorder with an autosomal recessive …
11 results