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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1996 3
1997 3
1998 3
1999 6
2000 10
2001 10
2002 13
2003 14
2004 5
2005 13
2006 8
2007 8
2008 7
2009 7
2010 15
2011 5
2012 5
2013 3
2014 3
2015 2
2016 7
2017 3
2018 3
2019 6
2020 5
2021 4
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2023 6
2024 2

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165 results

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Page 1
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Levin BL, Varga E. Levin BL, et al. J Genet Couns. 2016 Oct;25(5):901-11. doi: 10.1007/s10897-016-9956-7. Epub 2016 Apr 30. J Genet Couns. 2016. PMID: 27130656 Review.
In addition, two polymorphic variants in this gene (C677T and A1298C) have been implicated in a mild form of MTHFR deficiency associated with hyperhomocysteinemia. Mild to moderate hyperhomocysteinemia has been previously implicated as a risk factor for cardiovascul …
In addition, two polymorphic variants in this gene (C677T and A1298C) have been implicated in a mild form of MTHFR deficiency associated wit …
ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.
Hickey SE, Curry CJ, Toriello HV. Hickey SE, et al. Genet Med. 2013 Feb;15(2):153-6. doi: 10.1038/gim.2012.165. Epub 2013 Jan 3. Genet Med. 2013. PMID: 23288205 Free article.
It was previously hypothesized that reduced enzyme activity of MTHFR led to mild hyperhomocysteinemia which led to an increased risk for venous thromboembolism, coronary heart disease, and recurrent pregnancy loss. Recent meta-analyses have disproven an association between …
It was previously hypothesized that reduced enzyme activity of MTHFR led to mild hyperhomocysteinemia which led to an increased risk …
Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management.
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Wu YC, Sun A. Chiang CP, et al. J Formos Med Assoc. 2019 Sep;118(9):1279-1289. doi: 10.1016/j.jfma.2018.10.023. Epub 2018 Nov 14. J Formos Med Assoc. 2019. PMID: 30446298 Free article. Review.
We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 20.9%, 20.1%, 4.8%, 2.6%, and 7.7% of 273 RAS patients, respectively. ...Because RAS is an immunologically-mediated disease, topical and systemic corticosteroid thera …
We also found anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia in 20.9%, 20.1%, 4.8%, 2.6%, and …
Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies.
Hamed SA. Hamed SA. Expert Rev Clin Pharmacol. 2019 Jan;12(1):61-90. doi: 10.1080/17512433.2019.1555468. Epub 2019 Jan 11. Expert Rev Clin Pharmacol. 2019. PMID: 30501441 Review.
They include (1) accumulation of uremic toxins resulting in neurotoxicity, blood-brain barrier injury, neuroinflammation, oxidative stress, apoptosis, brain neurotransmitters imbalance, ischemic/microvascular changes, and brain metabolism dysfunction (e.g. dopamine deficiency), ( …
They include (1) accumulation of uremic toxins resulting in neurotoxicity, blood-brain barrier injury, neuroinflammation, oxidative stress, …
The treatment of hyperhomocysteinemia.
Maron BA, Loscalzo J. Maron BA, et al. Annu Rev Med. 2009;60:39-54. doi: 10.1146/annurev.med.60.041807.123308. Annu Rev Med. 2009. PMID: 18729731 Free PMC article. Review.
Although combined folic acid and B-vitamin therapy substantially reduces homocysteine levels, results from randomized placebo-controlled clinical trials testing the effect of vitamin therapy on outcome in these diseases have generally fallen short of expectations. . …
Although combined folic acid and B-vitamin therapy substantially reduces homocysteine levels, results from randomized placebo-control …
Diagnosis and treatment of hyperhomocysteinemia.
Keebler ME, De Souza C, Fonseca V. Keebler ME, et al. Curr Atheroscler Rep. 2001 Jan;3(1):54-63. doi: 10.1007/s11883-001-0011-1. Curr Atheroscler Rep. 2001. PMID: 11123849 Review.
Hyperhomocysteinemia has emerged as an important risk factor for cardiovascular disease. However, its place in clinical practice is somewhat unclear, due to the lack of clinical trials documenting the benefit of treatment on reducing cardiovascular events. Vitamin thera …
Hyperhomocysteinemia has emerged as an important risk factor for cardiovascular disease. However, its place in clinical practice is s …
Investigation and Management of Recurrent Pregnancy Loss: A Comprehensive Review of Guidelines.
Giouleka S, Tsakiridis I, Arsenaki E, Kalogiannidis I, Mamopoulos A, Papanikolaou E, Athanasiadis A, Dagklis T. Giouleka S, et al. Obstet Gynecol Surv. 2023 May;78(5):287-301. doi: 10.1097/OGX.0000000000001133. Obstet Gynecol Surv. 2023. PMID: 37263963 Review.
IMPORTANCE: Recurrent pregnancy loss (RPL) is one of the most frustrating clinical entities in reproductive medicine requiring not only diagnostic investigation and therapeutic intervention, but also evaluation of the risk for recurrence. ...Several differences exist regar …
IMPORTANCE: Recurrent pregnancy loss (RPL) is one of the most frustrating clinical entities in reproductive medicine requiring not only diag …
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
Barić I, Staufner C, Augoustides-Savvopoulou P, Chien YH, Dobbelaere D, Grünert SC, Opladen T, Petković Ramadža D, Rakić B, Wedell A, Blom HJ. Barić I, et al. J Inherit Metab Dis. 2017 Jan;40(1):5-20. doi: 10.1007/s10545-016-9972-7. Epub 2016 Sep 26. J Inherit Metab Dis. 2017. PMID: 27671891 Free PMC article. Review.
Following search of the literature and evaluation according to the SIGN-methodology of all reported patients with methylation defects, graded recommendations are provided in a structured way comprising diagnosis (clinical presentation, biochemical abnormalities, differential diag …
Following search of the literature and evaluation according to the SIGN-methodology of all reported patients with methylation defects, grade …
Combination of Taurine and Black Pepper Extract as a Treatment for Cardiovascular and Coronary Artery Diseases.
Swiderski J, Sakkal S, Apostolopoulos V, Zulli A, Gadanec LK. Swiderski J, et al. Nutrients. 2023 May 30;15(11):2562. doi: 10.3390/nu15112562. Nutrients. 2023. PMID: 37299525 Free PMC article. Review.
This comprehensive review of the literature focuses on determining whether the combination of taurine and black pepper extract is an effective natural treatment for reducing cardiovascular diseases risk factors (i.e., hypertension and hyperhomocysteinemia) and for driving …
This comprehensive review of the literature focuses on determining whether the combination of taurine and black pepper extract is an effecti …
Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease.
Kang SS, Rosenson RS. Kang SS, et al. Cardiovasc Drugs Ther. 2018 Apr;32(2):233-240. doi: 10.1007/s10557-018-6790-1. Cardiovasc Drugs Ther. 2018. PMID: 29679304 Review.

The majority of subjects with homocysteine > 15 mumol/L exhibit plasma folate < 9 nmol/ L, indicating that depletion of folate is the main cause of hyperhomocysteinemia irrespective of the presence or absence of vascular disease. ...Whether correction of hyperhomo

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The majority of subjects with homocysteine > 15 mumol/L exhibit plasma folate < 9 nmol/ L, indicating that depletion of folate is the

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165 results