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60 results

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Page 1
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G. Henter JI, et al. Pediatr Blood Cancer. 2007 Feb;48(2):124-31. doi: 10.1002/pbc.21039. Pediatr Blood Cancer. 2007. PMID: 16937360
HLH-2004 chemo-immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids. Subsequent hematopoietic stem cell transplantation (HSCT) is recommended for patients with familial …
HLH-2004 chemo-immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy …
Massive obstetric hemorrhage: Current approach to management.
Guasch E, Gilsanz F. Guasch E, et al. Med Intensiva. 2016 Jun-Jul;40(5):298-310. doi: 10.1016/j.medin.2016.02.010. Epub 2016 May 13. Med Intensiva. 2016. PMID: 27184441 Free article. Review. English, Spanish.
It is defined (among others) as the loss of>2,500ml of blood, and is associated to a need for admission to critical care and/or hysterectomy. The relative hemodilution and high cardiac output found in normal pregnancy allows substantial bleeding before a drop in hemoglo …
It is defined (among others) as the loss of>2,500ml of blood, and is associated to a need for admission to critical care and/or hy …
Etiology and management of hypofibrinogenemia in trauma.
Nathwani R, Proumen A, Blaine KP. Nathwani R, et al. Curr Opin Anaesthesiol. 2023 Jun 1;36(3):382-387. doi: 10.1097/ACO.0000000000001265. Epub 2023 Mar 6. Curr Opin Anaesthesiol. 2023. PMID: 36994749 Review.
PURPOSE OF REVIEW: Fibrin polymerization is essential for stable clot formation in trauma, and hypofibrinogenemia reduces hemostasis in trauma. This review considers fibrinogen biology, the changes that fibrinogen undergoes after major trauma, and current evidence for lab …
PURPOSE OF REVIEW: Fibrin polymerization is essential for stable clot formation in trauma, and hypofibrinogenemia reduces hemostasis …
Coagulation management and transfusion in massive postpartum hemorrhage.
Massoth C, Wenk M, Meybohm P, Kranke P. Massoth C, et al. Curr Opin Anaesthesiol. 2023 Jun 1;36(3):281-287. doi: 10.1097/ACO.0000000000001258. Epub 2023 Feb 22. Curr Opin Anaesthesiol. 2023. PMID: 36815533 Review.
SUMMARY: Factor deficiency is uncommon at the beginning of most etiologies of PPH but will eventually develop from consumption and depletion in the absence of bleeding control. The sensitivity of point-of-care tests for fibrinolysis is too low and may delay treatment, ther …
SUMMARY: Factor deficiency is uncommon at the beginning of most etiologies of PPH but will eventually develop from consumption and depletion …
Similar but not the same: Differential diagnosis of HLH and sepsis.
Machowicz R, Janka G, Wiktor-Jedrzejczak W. Machowicz R, et al. Crit Rev Oncol Hematol. 2017 Jun;114:1-12. doi: 10.1016/j.critrevonc.2017.03.023. Epub 2017 Mar 23. Crit Rev Oncol Hematol. 2017. PMID: 28477737 Review.
Differential diagnosis of hemophagocytic lymphohistiocytosis (HLH; hemophagocytic syndrome) and sepsis is critically important because the life-saving aggressive immunosuppressive treatment, required in the effective HLH therapy, is absent in sepsis guidelines. Moreover, H …
Differential diagnosis of hemophagocytic lymphohistiocytosis (HLH; hemophagocytic syndrome) and sepsis is critically important because the l …
Clinical Features and Management of Congenital Fibrinogen Deficiencies.
Casini A, de Moerloose P, Neerman-Arbez M. Casini A, et al. Semin Thromb Hemost. 2016 Jun;42(4):366-74. doi: 10.1055/s-0036-1571339. Epub 2016 Mar 28. Semin Thromb Hemost. 2016. PMID: 27019462 Review.
Congenital fibrinogen disorders are rare diseases affecting either the quantity (afibrinogenemia and hypofibrinogenemia) or the quality (dysfibrinogenemia) or both (hypodysfibrinogenemia) of plasmatic fibrinogen. ...
Congenital fibrinogen disorders are rare diseases affecting either the quantity (afibrinogenemia and hypofibrinogenemia) or the quali …
Clinical characteristics, treatment, and management of pembrolizumab induced hemophagocytic lymphohistiocytosis.
Wang C, Sun W, Li Z, Wu T, Fang W. Wang C, et al. Invest New Drugs. 2023 Dec;41(6):834-841. doi: 10.1007/s10637-023-01404-0. Epub 2023 Oct 28. Invest New Drugs. 2023. PMID: 37897650
Laboratory examination revealed revealed anemia (18 cases, 75.0%), leukopenia (12 cases, 50.0%), thrombocytopenia (20 cases, 83.3%), hypertriglyceridemia (11 cases, 45.8%), hypofibrinogenemia (11 cases, 45.8%). decreased natural killer cell function (7 cases, 29.2%), and e …
Laboratory examination revealed revealed anemia (18 cases, 75.0%), leukopenia (12 cases, 50.0%), thrombocytopenia (20 cases, 83.3%), hypertr …
Fibrinogen for the management of critical obstetric hemorrhage.
Matsunaga S, Takai Y, Seki H. Matsunaga S, et al. J Obstet Gynaecol Res. 2019 Jan;45(1):13-21. doi: 10.1111/jog.13788. Epub 2018 Aug 28. J Obstet Gynaecol Res. 2019. PMID: 30155944 Free PMC article. Review.
In this review, we investigated the effect of fibrinogen level on hemostasis and what we can do to treat hypofibrinogenemia efficiently and improve patients' outcome. METHODS: We reviewed numerous articles related to hypofibrinogenemia in critical obstetric hemorrha …
In this review, we investigated the effect of fibrinogen level on hemostasis and what we can do to treat hypofibrinogenemia efficient …
Role of fibrinogen concentrates for treatment of critical perioperative hemorrhage.
Koller T, Parera Ruiz A, Diaz-Ricart M, Gómez Caro AM. Koller T, et al. Drugs Today (Barc). 2021 Mar;57(3):219-239. doi: 10.1358/dot.2021.57.3.3250287. Drugs Today (Barc). 2021. PMID: 33729219 Review.
Acquired hypofibrinogenemia is a frequent cause of maintained bleeding in perioperative high-risk settings. Loss, consumption and dilution under resuscitation fluid therapy are the principal causes for fibrinogen depletion. Severe hypofibrinogenemia is freque …
Acquired hypofibrinogenemia is a frequent cause of maintained bleeding in perioperative high-risk settings. Loss, consumption and dil …
Transfusion and coagulation management in major obstetric hemorrhage.
Butwick AJ, Goodnough LT. Butwick AJ, et al. Curr Opin Anaesthesiol. 2015 Jun;28(3):275-84. doi: 10.1097/ACO.0000000000000180. Curr Opin Anaesthesiol. 2015. PMID: 25812005 Free PMC article. Review.
During early postpartum bleeding, recent studies have shown that hypofibrinogenemia is an important predictor for the later development of severe PPH. ...However, future studies are needed to assess whether formula-driven vs. goal-directed transfusion therapy improv …
During early postpartum bleeding, recent studies have shown that hypofibrinogenemia is an important predictor for the later developme …
60 results