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Management of antiphospholipid syndrome.
Uthman I, Noureldine MHA, Ruiz-Irastorza G, Khamashta M. Uthman I, et al. Ann Rheum Dis. 2019 Feb;78(2):155-161. doi: 10.1136/annrheumdis-2018-213846. Epub 2018 Oct 3. Ann Rheum Dis. 2019. PMID: 30282668 Review.
The clinical spectrum of antiphospholipid syndrome involves haematological (thrombocytopaenia, venous thrombosis), obstetrical (recurrent pregnancy loss), neurological (stroke, transient ischaemic attack, migraine, seizures, cognitive dysfunction, chorea, transverse myelitis, mul …
The clinical spectrum of antiphospholipid syndrome involves haematological (thrombocytopaenia, venous thrombosis), obstetrical (recurrent pr …
Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances.
Sciascia S, Amigo MC, Roccatello D, Khamashta M. Sciascia S, et al. Nat Rev Rheumatol. 2017 Sep;13(9):548-560. doi: 10.1038/nrrheum.2017.124. Epub 2017 Aug 3. Nat Rev Rheumatol. 2017. PMID: 28769114 Free article. Review.
However, the clinical spectrum of APS encompasses additional manifestations that can affect many organs and cannot be explained exclusively by patients being in a prothrombotic state; clinical manifestations not listed in the classification criteria (known as extra-criteria manif …
However, the clinical spectrum of APS encompasses additional manifestations that can affect many organs and cannot be explained exclusively …
Cutaneous lupus erythematosus: issues in diagnosis and treatment.
Walling HW, Sontheimer RD. Walling HW, et al. Am J Clin Dermatol. 2009;10(6):365-81. doi: 10.2165/11310780-000000000-00000. Am J Clin Dermatol. 2009. PMID: 19824738 Review.
Common cutaneous disease associated with, but not specific for, LE includes vasculitis, livedo reticularis, alopecia, digital manifestations such as periungual telangiectasia and Raynaud phenomenon, photosensitivity, and bullous lesions. ...Additional systemic therapies …
Common cutaneous disease associated with, but not specific for, LE includes vasculitis, livedo reticularis, alopecia, digital manifes …
Deficiency of Adenosine Deaminase 2 (DADA2): Updates on the Phenotype, Genetics, Pathogenesis, and Treatment.
Meyts I, Aksentijevich I. Meyts I, et al. J Clin Immunol. 2018 Jul;38(5):569-578. doi: 10.1007/s10875-018-0525-8. Epub 2018 Jun 27. J Clin Immunol. 2018. PMID: 29951947 Free PMC article. Review.
Over 60 disease-associated mutations have been identified in all domains of ADA2 affecting the catalytic activity, protein dimerization, and secretion. Vasculopathy ranging from livedo reticularis to polyarteritis nodosa (PAN) and life-threatening ischemic and/or hemorrhag …
Over 60 disease-associated mutations have been identified in all domains of ADA2 affecting the catalytic activity, protein dimerization, and …
Management of Non-criteria Manifestations in Antiphospholipid Syndrome.
Xourgia E, Tektonidou MG. Xourgia E, et al. Curr Rheumatol Rep. 2020 Jul 22;22(9):51. doi: 10.1007/s11926-020-00935-2. Curr Rheumatol Rep. 2020. PMID: 32699944 Review.
PURPOSE OF THE REVIEW: To review the available evidence on the management of a variety of non-criteria manifestations in antiphospholipid syndrome (APS), including valvular disease, alveolar hemorrhage, thrombocytopenia, hemolytic anemia, APS nephropathy, skin ulcers, livedo …
PURPOSE OF THE REVIEW: To review the available evidence on the management of a variety of non-criteria manifestations in antiphospholipid sy …
Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment.
Dabiri G, Damstetter E, Chang Y, Baiyee Ebot E, Powers JG, Phillips T. Dabiri G, et al. J Am Acad Dermatol. 2016 May;74(5):795-804; quiz 805-6. doi: 10.1016/j.jaad.2015.08.071. J Am Acad Dermatol. 2016. PMID: 27085226 Review.
Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, livedo reticularis, and ulcerations. A good history and physical examination are crucial to diagnoses of these conditions. ...Diagnostic stu …
Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, live …
Efficacy and safety of amantadine for the treatment of L-DOPA-induced dyskinesia.
Perez-Lloret S, Rascol O. Perez-Lloret S, et al. J Neural Transm (Vienna). 2018 Aug;125(8):1237-1250. doi: 10.1007/s00702-018-1869-1. Epub 2018 Mar 7. J Neural Transm (Vienna). 2018. PMID: 29511826 Review.
The most common adverse reactions with amantadine are constipation, cardiovascular dysfunction including QT prolongation, orthostatic hypotension and edema, neuropsychiatric symptoms such as hallucinations, confusion and delirium, nausea and livedo reticularis. Corneal deg …
The most common adverse reactions with amantadine are constipation, cardiovascular dysfunction including QT prolongation, orthostatic hypote …
Livedo racemosa in neurological diseases: an update on the differential diagnoses.
Mitri F, Enk A, Bersano A, Kraemer M. Mitri F, et al. Eur J Neurol. 2020 Oct;27(10):1832-1843. doi: 10.1111/ene.14390. Epub 2020 Jul 2. Eur J Neurol. 2020. PMID: 32526049 Review.
Livedo is a net-like violaceous skin pattern. It can be classified as physiological or pathological. The physiological livedo reticularis usually appears in cold conditions, whereas the pathological and irregular livedo, which persists in warm temperatures, i …
Livedo is a net-like violaceous skin pattern. It can be classified as physiological or pathological. The physiological livedo …
Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients.
Li S, Bai Y, Meng J, Wang Q, Tian X, Li M, Zeng X, Zhao J, Hu C. Li S, et al. Front Immunol. 2023 Apr 12;14:1107510. doi: 10.3389/fimmu.2023.1107510. eCollection 2023. Front Immunol. 2023. PMID: 37122726 Free PMC article.
Valve lesion was positively associated with aSM IgM (Fisher test p = 0.039), APS nephropathy was associated with aPC IgG (OR 3.797), and livedo reticularis was associated with aPE IgM (OR 15.391). CONCLUSION: Additional detection of non-criteria aPLs including aPC IgG/M, a …
Valve lesion was positively associated with aSM IgM (Fisher test p = 0.039), APS nephropathy was associated with aPC IgG (OR 3.797), and …
Non-criteria manifestations in primary antiphospholipid syndrome: a French multicenter retrospective cohort study.
Guédon AF, Catano J, Ricard L, Laurent C, de Moreuil C, Urbanski G, Deriaz S, Gerotziafas G, Elalamy I, Audemard A, Chasset F, Alamowitch S, Sellam J, Maillot F, Boffa JJ, Cohen A, Abisror N, Fain O, Mekinian A. Guédon AF, et al. Arthritis Res Ther. 2022 Jan 25;24(1):33. doi: 10.1186/s13075-022-02726-9. Arthritis Res Ther. 2022. PMID: 35078523 Free PMC article.
Among them, forty-three patients (24.0%) presented at least one non-criteria manifestation during the follow-up: autoimmune cytopenias (n = 17; 39.5%), Libman Sachs endocarditis (n = 5; 11.6%), APS nephropathy (n = 4; 9.3%), livedo reticularis (n = 8; 18.6%), and neurologi …
Among them, forty-three patients (24.0%) presented at least one non-criteria manifestation during the follow-up: autoimmune cytopenias (n = …
32 results