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Management of epilepsy in MERRF syndrome.
Finsterer J, Zarrouk-Mahjoub S. Finsterer J, et al. Seizure. 2017 Aug;50:166-170. doi: 10.1016/j.seizure.2017.06.010. Epub 2017 Jun 24. Seizure. 2017. PMID: 28686997 Free article. Review.
Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare syndromic mitochondrial disorder (MID) with a broad phenotypic but narrow genotypic heterogeneity. One of the predominant phenotypic features in addition to myopathy is epilepsy. The most frequent seiz …
Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare syndromic mitochondrial disorder (MID) with a broad phenotypic b …
Genotype and phenotype features and prognostic factors of neonatal-onset pyridoxine-dependent epilepsy: A systematic review.
Fang C, Yang L, Xiao F, Yan K, Zhou W. Fang C, et al. Epilepsy Res. 2024 May;202:107363. doi: 10.1016/j.eplepsyres.2024.107363. Epub 2024 Apr 17. Epilepsy Res. 2024. PMID: 38636407
All patients were treated with pyridoxine; forty patients received dietary intervention therapy. 63.9 % of the patients were completely seizure-free; however, 68.6 % of the patients had neurodevelopmental delays. ...Prenatal movement abnormality (P=0.041; OR: 20.56) …
All patients were treated with pyridoxine; forty patients received dietary intervention therapy. 63.9 % of the patients were complete …
The efficacy and tolerability of pharmacologic treatment options for Lennox-Gastaut syndrome.
Montouris GD, Wheless JW, Glauser TA. Montouris GD, et al. Epilepsia. 2014 Sep;55 Suppl 4:10-20. doi: 10.1111/epi.12732. Epilepsia. 2014. PMID: 25284033 Free article. Review.
LGS is characterized by a slow spike-wave pattern on electroencephalogram (EEG), cognitive impairment, and multiple seizure types. This mixture of seizure types, along with the need to use more than one type of medication, makes LGS one of the most complicated epile …
LGS is characterized by a slow spike-wave pattern on electroencephalogram (EEG), cognitive impairment, and multiple seizure types. Th …
Perampanel for the treatment of patients with myoclonic seizures in clinical practice: Evidence from the PERMIT study.
D'Souza W, Alsaadi T, Montoya J, Carreño M, Di Bonaventura C, Mohanraj R, Yamamoto T, McMurray R, Shastri O, Villanueva V; PERMIT study group. D'Souza W, et al. Seizure. 2022 Aug;100:56-66. doi: 10.1016/j.seizure.2022.06.008. Epub 2022 Jun 15. Seizure. 2022. PMID: 35777333 Free article.
Safety and tolerability were assessed by evaluating adverse events (AEs) and discontinuation due to AEs. RESULTS: 156 patients had myoclonic seizures (59.0% female; mean age, 32.1 years; idiopathic generalised epilepsy, 89.1%; Juvenile Myoclonic Epilepsy, 63.1%; mon …
Safety and tolerability were assessed by evaluating adverse events (AEs) and discontinuation due to AEs. RESULTS: 156 patients had myoclo …
Evolving antiepileptic drug treatment in juvenile myoclonic epilepsy.
Prasad A, Kuzniecky RI, Knowlton RC, Welty TE, Martin RC, Mendez M, Faught RE. Prasad A, et al. Arch Neurol. 2003 Aug;60(8):1100-5. doi: 10.1001/archneur.60.8.1100. Arch Neurol. 2003. PMID: 12925366
The combined data of myoclonic seizure control by all 3 AEDs were poorer when compared with the combined data of generalized tonic-clonic seizure control by all 3 AEDs (P =.03), but not when compared with the combined data of absence seizure control by …
The combined data of myoclonic seizure control by all 3 AEDs were poorer when compared with the combined data of generalized t …
Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open-label study.
Lowrie M, Thomson S, Bessant C, Sparkes A, Harvey RJ, Garosi L. Lowrie M, et al. J Feline Med Surg. 2017 Feb;19(2):200-206. doi: 10.1177/1098612X15622806. Epub 2016 Jul 9. J Feline Med Surg. 2017. PMID: 26690830
Methods This prospective, randomised, open-label trial compared the efficacy and tolerability of levetiracetam (20-25 mg/kg q8h) with phenobarbital (3-5 mg/kg q12h) in cats with suspected FARS that experienced myoclonic seizures. Cats were included that had 12 myoclonic …
Methods This prospective, randomised, open-label trial compared the efficacy and tolerability of levetiracetam (20-25 mg/kg q8h) with phenob …
Vigabatrin in the management of generalized seizures in children.
Appleton RE. Appleton RE. Seizure. 1995 Mar;4(1):45-8. doi: 10.1016/s1059-1311(05)80077-9. Seizure. 1995. PMID: 7788106 Free article. Review.
By contrast West syndrome is easier to evaluate as the spasms are the only, and characteristic, seizure type. Vigabatrin has been used as both add-on, and monotherapy in the treatment of spasms. ...The limited, reported data on VGB-monotherapy in West syndrome have been en …
By contrast West syndrome is easier to evaluate as the spasms are the only, and characteristic, seizure type. Vigabatrin has been use …