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Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration.
Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL 3rd, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, Munoz DG, Dickson DW, Ince PG, Trojanowski JQ, Mann DM; Consortium for Frontotemporal Lobar Degeneration. Cairns NJ, et al. Acta Neuropathol. 2007 Jul;114(1):5-22. doi: 10.1007/s00401-007-0237-2. Epub 2007 Jun 20. Acta Neuropathol. 2007. PMID: 17579875 Free PMC article.
The proposed criteria take into account new disease entities and include the novel molecular pathology, TDP-43 proteinopathy, now recognized to be the most frequent histological finding in FTLD. ...In addition to genetic heterogeneity amongst the TDP- …
The proposed criteria take into account new disease entities and include the novel molecular pathology, TDP-43 proteinopath
Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barre syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.
Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H. Hosokawa M, et al. Int J Neurosci. 2014 May;124(5):344-9. doi: 10.3109/00207454.2013.848440. Epub 2013 Oct 31. Int J Neurosci. 2014. PMID: 24066851
Increased TDP-43 in the CSF could be a hallmark of ALS and other TDP-43 proteinopathy. Sandwich enzyme-linked immunosorbent assay (ELISA) was established to measure the concentration of TDP-43 in biological fluids. Culture supernat …
Increased TDP-43 in the CSF could be a hallmark of ALS and other TDP-43 proteinopathy. Sandwich enzyme-li …
Primary progressive aphasia and the language network: the 2013 H. Houston Merritt Lecture.
Mesulam MM. Mesulam MM. Neurology. 2013 Jul 30;81(5):456-62. doi: 10.1212/WNL.0b013e31829d87df. Neurology. 2013. PMID: 23897873
The most common underlying neuropathology is frontotemporal degeneration with tauopathy in PPA-G, frontotemporal degeneration with TDP-43 proteinopathy in PPA-S, and Alzheimer pathology in PPA-L. ...A history of learning disability, including dyslexia, is eme …
The most common underlying neuropathology is frontotemporal degeneration with tauopathy in PPA-G, frontotemporal degeneration with TDP
Targeting Protein Kinase CK1delta with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?
Bissaro M, Federico S, Salmaso V, Sturlese M, Spalluto G, Moro S. Bissaro M, et al. ChemMedChem. 2018 Dec 20;13(24):2601-2605. doi: 10.1002/cmdc.201800632. Epub 2018 Nov 21. ChemMedChem. 2018. PMID: 30359484 Free article.
The inhibition of CK1delta catalytic activity indeed links the two main pathological hallmarks of ALS: transactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy and glutamate excitotoxicity, exacerbated by the loss of expression of glia …
The inhibition of CK1delta catalytic activity indeed links the two main pathological hallmarks of ALS: transactive response DNA-binding prot …