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Page 1
Endocan in Acute Leukemia: Current Knowledge and Future Perspectives.
Reikvam H, Hatfield KJ, Wendelbo Ø, Lindås R, Lassalle P, Bruserud Ø. Reikvam H, et al. Biomolecules. 2022 Mar 24;12(4):492. doi: 10.3390/biom12040492. Biomolecules. 2022. PMID: 35454082 Free PMC article. Review.
Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor levels) has an adverse prognostic impact in several malignancies. The p14 endocan degradation product can also be detected in serum/pla …
Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor le …
Cleaved endocan acts as a biologic competitor of endocan in the control of ICAM-1-dependent leukocyte diapedesis.
Gaudet A, Portier L, Mathieu D, Hureau M, Tsicopoulos A, Lassalle P, De Freitas Caires N. Gaudet A, et al. J Leukoc Biol. 2020 May;107(5):833-841. doi: 10.1002/JLB.3AB0320-612RR. Epub 2020 Apr 9. J Leukoc Biol. 2020. PMID: 32272492
Recent data have highlighted the hypothetic role of p14, endocan's major catabolite found in the bloodstream of septic patients, as a potential antagonist of endocan, thus participating in the regulation of acute inflammation. We hereby characterize the role of p14 …
Recent data have highlighted the hypothetic role of p14, endocan's major catabolite found in the bloodstream of septic patients, as a …
Can endocan serve as a molecular "hepatostat" in liver regeneration?
Yazici SE, Gedik ME, Leblebici CB, Kosemehmetoglu K, Gunaydin G, Dogrul AB. Yazici SE, et al. Mol Med. 2023 Feb 27;29(1):29. doi: 10.1186/s10020-023-00622-9. Mol Med. 2023. PMID: 36849916 Free PMC article.
Liver tissue protein levels of endostatin, endocan and p-eEF2K/eEF2K were determined with Western blot. Serum levels of endostatin and endocan were assessed with ELISA. RESULTS: Pcna expression level in residual liver tissues peaked on day-1, while Vegf expression r …
Liver tissue protein levels of endostatin, endocan and p-eEF2K/eEF2K were determined with Western blot. Serum levels of endostatin an …
Downregulation of ENDOCAN in myeloid leukemia cells inhibits proliferation and promotes apoptosis by suppressing nuclear factor-kappaB activity.
Sun L, Sun C, Sun J, Yang W. Sun L, et al. Mol Med Rep. 2019 Apr;19(4):3247-3254. doi: 10.3892/mmr.2019.9969. Epub 2019 Feb 19. Mol Med Rep. 2019. PMID: 30816462
Subsequently, ENDOCAN was knocked down in U937 and K562 cells via lentiviral infection. ...Furthermore, cell apoptosis was increased in response to ENDOCAN silencing, which was accompanied by the downregulation of B-cell lymphoma (BCL2) and the upregulation of BCL2- …
Subsequently, ENDOCAN was knocked down in U937 and K562 cells via lentiviral infection. ...Furthermore, cell apoptosis was increased …
Endothelial Cell-Specific Molecule-1 in Critically Ill Patients With Hematologic Malignancy.
Zafrani L, Resche-Rigon M, De Freitas Caires N, Gaudet A, Mathieu D, Parmentier-Decrucq E, Lemiale V, Mokart D, Pène F, Kouatchet A, Mayaux J, Vincent F, N'yunga M, Bruneel F, Rabbat A, Lebert C, Perez P, Meert AP, Benoit D, Darmon M, Azoulay E. Zafrani L, et al. Crit Care Med. 2018 Mar;46(3):e250-e257. doi: 10.1097/CCM.0000000000002934. Crit Care Med. 2018. PMID: 29474336
The predictive value of endocan peptide fragments of 14 kDa in terms of mortality and life-sustaining therapies requirement was inferior to that of total endocan. Endocan levels were higher in critically ill hematology patients compared with healthy su …
The predictive value of endocan peptide fragments of 14 kDa in terms of mortality and life-sustaining therapies requirement wa …
Increased Extravascular Lung Water and Plasma Biomarkers of Acute Lung Injury Precede Oxygenation Impairment in Primary Graft Dysfunction After Lung Transplantation.
Pottecher J, Roche AC, Dégot T, Helms O, Hentz JG, Schmitt JP, Falcoz PE, Santelmo N, Levy F, Collange O, Uring-Lambert B, Bahram S, Schaeffer M, Meyer N, Geny B, Lassalle P, Diemunsch P, Massard G, Kessler R, Steib A; Groupe de Transplantation Pulmonaire des Hôpitaux Universitaires de Strasbourg. Pottecher J, et al. Transplantation. 2017 Jan;101(1):112-121. doi: 10.1097/TP.0000000000001434. Transplantation. 2017. PMID: 27495752
Transpulmonary thermodilution-based EVLWi, plasma concentrations of epithelial (soluble receptor for advanced glycation endproducts [sRAGE]) and endothelial biomarkers (soluble intercellular adhesion molecule-1 and endocan [full-length and cleaved p14 fragment …
Transpulmonary thermodilution-based EVLWi, plasma concentrations of epithelial (soluble receptor for advanced glycation endproducts [sRAGE]) …
Identification of a 14 kDa endocan fragment generated by cathepsin G, a novel circulating biomarker in patients with sepsis.
De Freitas Caires N, Legendre B, Parmentier E, Scherpereel A, Tsicopoulos A, Mathieu D, Lassalle P. De Freitas Caires N, et al. J Pharm Biomed Anal. 2013 May 5;78-79:45-51. doi: 10.1016/j.jpba.2013.01.035. Epub 2013 Feb 9. J Pharm Biomed Anal. 2013. PMID: 23454598
We demonstrate that cathepsin G (CG), neutrophil elastase (NE), and to a lesser extent proteinase 3 (PR3), degrade endocan. Interestingly, a novel endocan peptide fragment of 14 kDa, named p14, was identified, resulting from the specific cleavage of endoca …
We demonstrate that cathepsin G (CG), neutrophil elastase (NE), and to a lesser extent proteinase 3 (PR3), degrade endocan. Interesti …
Activation of coagulation and endothelium with concurrent impairment of anticoagulant mechanisms in patients with typhoid fever.
de Jong HK, Parry CM, van der Vaart TW, Kager LM, van den Ende SJ, Maude RR, Wijedoru L, Ghose A, Hassan MU, Hossain MA, Dondorp AM, Baker S, Faiz MA, Meijers JCM, Wiersinga WJ. de Jong HK, et al. J Infect. 2018 Jul;77(1):60-67. doi: 10.1016/j.jinf.2018.03.008. Epub 2018 May 7. J Infect. 2018. PMID: 29746945 Free article.
RESULTS: Patients demonstrated activation of the coagulation system, as reflected by elevated in vitro thrombin generation and high plasma levels of fibrinogen, D-dimer and prothrombin fragment F1 + 2 in concert with consumption of coagulation factors resulting in a prolon …
RESULTS: Patients demonstrated activation of the coagulation system, as reflected by elevated in vitro thrombin generation and high plasma l …
Effects of Dexmedetomidine on Intestinal Microcirculation and Intestinal Epithelial Barrier in Endotoxemic Rats.
Yeh YC, Wu CY, Cheng YJ, Liu CM, Hsiao JK, Chan WS, Wu ZG, Yu LC, Sun WZ. Yeh YC, et al. Anesthesiology. 2016 Aug;125(2):355-67. doi: 10.1097/ALN.0000000000001135. Anesthesiology. 2016. PMID: 27111533 Free article.
RESULTS: The density of perfused small vessels in mucosa, serosal muscular layer, and Peyer patch in the lipopolysaccharide + dexmedetomidine group was higher than that of the lipopolysaccharide group. Serum endocan level was lower in the lipopolysaccharide + dexmedetomidi …
RESULTS: The density of perfused small vessels in mucosa, serosal muscular layer, and Peyer patch in the lipopolysaccharide + dexmedetomidin …
12 results