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2014 2
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2017 3
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Page 1
Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis.
Zhang H, Xu C, Shi C, Zhang J, Qian T, Wang Z, Ma R, Wu J, Jiang F, Feng J. Zhang H, et al. J Transl Med. 2021 Mar 5;19(1):98. doi: 10.1186/s12967-021-02770-0. J Transl Med. 2021. PMID: 33663522 Free PMC article.
K-M survival analysis showed that hypermethylation-low expression of heparanase 2 (HPSE2) was related to poor patient prognosis. Overexpression of HPSE2 reduced cell proliferation in vivo and in vitro. HPSE2 could regulate the p53 signaling path …
K-M survival analysis showed that hypermethylation-low expression of heparanase 2 (HPSE2) was related to poor patient p …
Urinary tract effects of HPSE2 mutations.
Stuart HM, Roberts NA, Hilton EN, McKenzie EA, Daly SB, Hadfield KD, Rahal JS, Gardiner NJ, Tanley SW, Lewis MA, Sites E, Angle B, Alves C, Lourenço T, Rodrigues M, Calado A, Amado M, Guerreiro N, Serras I, Beetz C, Varga RE, Silay MS, Darlow JM, Dobson MG, Barton DE, Hunziker M, Puri P, Feather SA, Goodship JA, Goodship TH, Lambert HJ, Cordell HJ; UK VUR Study Group; Saggar A, Kinali M; 4C Study Group; Lorenz C, Moeller K, Schaefer F, Bayazit AK, Weber S, Newman WG, Woolf AS. Stuart HM, et al. J Am Soc Nephrol. 2015 Apr;26(4):797-804. doi: 10.1681/ASN.2013090961. Epub 2014 Aug 21. J Am Soc Nephrol. 2015. PMID: 25145936 Free PMC article.
Urofacial syndrome (UFS) is an autosomal recessive congenital disease featuring grimacing and incomplete bladder emptying. Mutations of HPSE2, encoding heparanase 2, a heparanase 1 inhibitor, occur in UFS, but knowledge about the HPSE2 mutation spectru …
Urofacial syndrome (UFS) is an autosomal recessive congenital disease featuring grimacing and incomplete bladder emptying. Mutations of H …
Urofacial (ochoa) syndrome: A literature review.
Osorio S, Rivillas ND, Martinez JA. Osorio S, et al. J Pediatr Urol. 2021 Apr;17(2):246-254. doi: 10.1016/j.jpurol.2021.01.017. Epub 2021 Jan 24. J Pediatr Urol. 2021. PMID: 33558177 Review.
It is associated with autosomal recessive inheritance mutations in the HPSE2 gene, located at 10q23-q24, and the LRGI2 gene, located in 1p13.2; however, in up to 16% of patients, no associated mutations have been found. ...
It is associated with autosomal recessive inheritance mutations in the HPSE2 gene, located at 10q23-q24, and the LRGI2 gene, located …
Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.
Ostrovsky O, Beider K, Magen H, Leiba M, Sanderson RD, Vlodavsky I, Nagler A. Ostrovsky O, et al. Cells. 2023 Mar 16;12(6):913. doi: 10.3390/cells12060913. Cells. 2023. PMID: 36980254 Free PMC article.
SNP rs657442, located in intron 9 of the HPSE2 gene, revealed a significant protective association with primary paraskeletal disease and lytic bone lesions. ...The effect of signal discrepancy between myeloma cells and normal cells of the tumor microenvironment is proposed …
SNP rs657442, located in intron 9 of the HPSE2 gene, revealed a significant protective association with primary paraskeletal disease …
Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease.
García B, Martín C, García-Suárez O, Muñiz-Alonso B, Ordiales H, Fernández-Menéndez S, Santos-Juanes J, Lorente-Gea L, Castañón S, Vicente-Etxenausia I, Piña Batista KM, Ruiz-Díaz I, Caballero-Martínez MC, Merayo-Lloves J, Guerra-Merino I, Quirós LM, Fernández-Vega I. García B, et al. J Alzheimers Dis. 2017;58(1):185-192. doi: 10.3233/JAD-161298. J Alzheimers Dis. 2017. PMID: 28387673
Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS). Heparanase 2 (HPSE2) lacks HS-degrading activity, although it is able to interact with HS with high affinity. OBJECTIVE: To analyze HPSE and HPSE2 expressions at different stages o …
Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS). Heparanase 2 (HPSE2) lacks HS-degrading activit …
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
Roberts NA, Hilton EN, Lopes FM, Singh S, Randles MJ, Gardiner NJ, Chopra K, Coletta R, Bajwa Z, Hall RJ, Yue WW, Schaefer F, Weber S, Henriksson R, Stuart HM, Hedman H, Newman WG, Woolf AS. Roberts NA, et al. Kidney Int. 2019 May;95(5):1138-1152. doi: 10.1016/j.kint.2018.11.040. Epub 2019 Mar 8. Kidney Int. 2019. PMID: 30885509 Free PMC article.
Mutations in leucine-rich-repeats and immunoglobulin-like-domains 2 (LRIG2) or in heparanase 2 (HPSE2) cause urofacial syndrome, a devastating autosomal recessive disease of functional bladder outlet obstruction. ...These observations provide evidence that a …
Mutations in leucine-rich-repeats and immunoglobulin-like-domains 2 (LRIG2) or in heparanase 2 (HPSE2) cause urofacial …
A mouse model of urofacial syndrome with dysfunctional urination.
Guo C, Kaneko S, Sun Y, Huang Y, Vlodavsky I, Li X, Li ZR, Li X. Guo C, et al. Hum Mol Genet. 2015 Apr 1;24(7):1991-9. doi: 10.1093/hmg/ddu613. Epub 2014 Dec 15. Hum Mol Genet. 2015. PMID: 25510506 Free PMC article.
Urofacial syndrome (UFS) is an autosomal recessive disease with severe dysfunctional urination including urinary incontinence (UI). Biallelic mutations of HPSE2 are discovered from UFS patients, suggesting that HPSE2 is a candidate disease gene. ...All Hpse2 …
Urofacial syndrome (UFS) is an autosomal recessive disease with severe dysfunctional urination including urinary incontinence (UI). Bialleli …
Role of heparanase 2 (Hpa2) in gastric cancer.
Liu J, Knani I, Gross-Cohen M, Hu J, Wang S, Tang L, Ilan N, Yang S, Vlodavsky I. Liu J, et al. Neoplasia. 2021 Sep;23(9):966-978. doi: 10.1016/j.neo.2021.07.010. Epub 2021 Jul 31. Neoplasia. 2021. PMID: 34343822 Free PMC article.
In striking contrast, only little attention was given to its close homolog, heparanase 2 (Hpa2), possibly because it lacks heparan sulfate-degrading activity typical of heparanase. ...
In striking contrast, only little attention was given to its close homolog, heparanase 2 (Hpa2), possibly because it lacks hep …
A Genome-Wide Association Study of Prediabetes Status Change.
Liu T, Li H, Conley YP, Primack BA, Wang J, Lo WJ, Li C. Liu T, et al. Front Endocrinol (Lausanne). 2022 Jun 13;13:881633. doi: 10.3389/fendo.2022.881633. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35769078 Free PMC article.

We robustly identified 5 novel genes that are associated with prediabetes status change using gene-based analyses, including SGCZ (ARIC p = 9.9310-6, FHS p = 2.0010-3, Meta p = 3.7210-7) at 8p22, HPSE2 (ARIC p = 8.2610-19, FHS p = 5.8510-3, Meta p < 8.2610-19) at 10q24.

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We robustly identified 5 novel genes that are associated with prediabetes status change using gene-based analyses, including SGCZ (ARIC p = …
Identifying signatures of positive selection in human populations from North Africa.
Caro-Consuegra R, Lucas-Sánchez M, Comas D, Bosch E. Caro-Consuegra R, et al. Sci Rep. 2023 May 20;13(1):8166. doi: 10.1038/s41598-023-35312-3. Sci Rep. 2023. PMID: 37210386 Free PMC article.
We also detect signatures of positive selection related to skin pigmentation (SLC24A5, KITLG), and immunity function (IL1R1, CD44, JAK1) shared with European populations and candidate genes associated with haemoglobin phenotypes (HPSE2, HBE1, HBG2), other immune-related (D …
We also detect signatures of positive selection related to skin pigmentation (SLC24A5, KITLG), and immunity function (IL1R1, CD44, JAK1) sha …
22 results