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Year Number of Results
2003 1
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2007 2
2010 1
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2013 3
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2016 1
2017 1
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2020 4
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50 results

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Page 1
Microglia regulate central nervous system myelin growth and integrity.
McNamara NB, Munro DAD, Bestard-Cuche N, Uyeda A, Bogie JFJ, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJA, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE. McNamara NB, et al. Among authors: bogie jfj, hendriks jja. Nature. 2023 Jan;613(7942):120-129. doi: 10.1038/s41586-022-05534-y. Epub 2022 Dec 14. Nature. 2023. PMID: 36517604 Free PMC article.
We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte state with altered lipid metabolism. Moreover, this mechanism is regulated through disruption of the TGFbeta1-TGFbetaR1 axis. ...
We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte …
Perilipin-2 limits remyelination by preventing lipid droplet degradation.
Loix M, Wouters E, Vanherle S, Dehairs J, McManaman JL, Kemps H, Swinnen JV, Haidar M, Bogie JFJ, Hendriks JJA. Loix M, et al. Among authors: bogie jfj, hendriks jja. Cell Mol Life Sci. 2022 Sep 13;79(10):515. doi: 10.1007/s00018-022-04547-0. Cell Mol Life Sci. 2022. PMID: 36100764 Free PMC article.
Importantly, Plin2-deficiency markedly improves remyelination in the ex vivo brain slice model and in the in vivo cuprizone-induced demyelination model. In summary, we identify PLIN2 as a novel therapeutic target to prevent the pathogenic accumulation of LDs in foamy phago …
Importantly, Plin2-deficiency markedly improves remyelination in the ex vivo brain slice model and in the in vivo cuprizone-induced d …
Targeting lipophagy in macrophages improves repair in multiple sclerosis.
Haidar M, Loix M, Vanherle S, Dierckx T, Vangansewinkel T, Gervois P, Wolfs E, Lambrichts I, Bogie JFJ, Hendriks JJA. Haidar M, et al. Among authors: bogie jfj, hendriks jja. Autophagy. 2022 Nov;18(11):2697-2710. doi: 10.1080/15548627.2022.2047343. Epub 2022 Mar 14. Autophagy. 2022. PMID: 35282773 Free PMC article.
Importantly, trehalose was able to boost remyelination in the ex vivo brain slice model and the in vivo cuprizone-induced demyelination model. In summary, our results provide a molecular rationale for impaired metabolism of myelin-derived lipids in macrophages, and identif …
Importantly, trehalose was able to boost remyelination in the ex vivo brain slice model and the in vivo cuprizone-induced demyelinati …
The physiology of foamy phagocytes in multiple sclerosis.
Grajchen E, Hendriks JJA, Bogie JFJ. Grajchen E, et al. Among authors: bogie jfj, hendriks jja. Acta Neuropathol Commun. 2018 Nov 19;6(1):124. doi: 10.1186/s40478-018-0628-8. Acta Neuropathol Commun. 2018. PMID: 30454040 Free PMC article. Review.
Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination.
Garcia Corrales AV, Verberk SGS, Haidar M, Grajchen E, Dehairs J, Vanherle S, Loix M, Weytjens T, Gervois P, Matsuzaka T, Lambrichts I, Swinnen JV, Bogie JFJ, Hendriks JJA. Garcia Corrales AV, et al. Among authors: bogie jfj, hendriks jja. Proc Natl Acad Sci U S A. 2023 Sep 12;120(37):e2301030120. doi: 10.1073/pnas.2301030120. Epub 2023 Sep 5. Proc Natl Acad Sci U S A. 2023. PMID: 37669365 Free PMC article.
These lesions mainly consist of phagocytes that play a key role in lesion progression and remyelination, and therefore represent a promising therapeutic target in MS. We recently showed that unsaturated fatty acids produced by stearoyl-CoA desaturase-1 induce inflammatory …
These lesions mainly consist of phagocytes that play a key role in lesion progression and remyelination, and therefore represent a pr …
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.
Bogie JFJ, Grajchen E, Wouters E, Corrales AG, Dierckx T, Vanherle S, Mailleux J, Gervois P, Wolfs E, Dehairs J, Van Broeckhoven J, Bowman AP, Lambrichts I, Gustafsson JÅ, Remaley AT, Mulder M, Swinnen JV, Haidar M, Ellis SR, Ntambi JM, Zelcer N, Hendriks JJA. Bogie JFJ, et al. Among authors: hendriks jja. J Exp Med. 2020 May 4;217(5):e20191660. doi: 10.1084/jem.20191660. J Exp Med. 2020. PMID: 32097464 Free PMC article.
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. ...Pharmacological inhibition or phagocyte-specific deficiency of Scd1 accelerated remyelination ex vivo and in vivo. These findings identify SCD1 as a no …
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. ...Pharmacological in …
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, Gervois P, Wolfs E, Lambrichts I, Brullo C, Bruno O, Fedele E, Ricciarelli R, Ffrench-Constant C, Bechler ME, van Schaik P, Baron W, Lefevere E, Wasner K, Grünewald A, Verfaillie C, Baeten P, Broux B, Wieringa P, Hellings N, Prickaerts J, Vanmierlo T. Schepers M, et al. Among authors: vanmierlo t, hellings n. Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020. Epub 2022 Dec 28. Brain Behav Immun. 2023. PMID: 36584795 Free article.
We show that inhibition of PDE4D boosts oligodendrocyte progenitor cells (OPC) differentiation and enhances (re)myelination of both murine OPCs and human iPSC-derived OPCs. In addition, PDE4D inhibition promotes in vivo remyelination in the cuprizone model, which is …
We show that inhibition of PDE4D boosts oligodendrocyte progenitor cells (OPC) differentiation and enhances (re)myelination of both m …
From OPC to Oligodendrocyte: An Epigenetic Journey.
Tiane A, Schepers M, Rombaut B, Hupperts R, Prickaerts J, Hellings N, van den Hove D, Vanmierlo T. Tiane A, et al. Among authors: vanmierlo t, hellings n. Cells. 2019 Oct 11;8(10):1236. doi: 10.3390/cells8101236. Cells. 2019. PMID: 31614602 Free PMC article. Review.
Oligodendrocytes need to be newly formed from a pool of oligodendrocyte precursor cells (OPCs). The differentiation of OPCs into mature and myelinating cells is a multistep process, tightly controlled by spatiotemporal activation and repression of specific growth and trans …
Oligodendrocytes need to be newly formed from a pool of oligodendrocyte precursor cells (OPCs). The differentiation of OPCs into matu …
Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders.
Loix M, Vanherle S, Turri M, Kemp S, Fernandes KJL, Hendriks JJA, Bogie JFJ. Loix M, et al. Among authors: bogie jfj, hendriks jja. Mol Neurodegener. 2024 Nov 19;19(1):85. doi: 10.1186/s13024-024-00778-w. Mol Neurodegener. 2024. PMID: 39563397 Free PMC article. Review.
This protective effect is achieved through different mechanisms including enhanced remyelination, reversal of synaptic and cognitive impairments, and mitigation of alpha-synuclein toxicity. ...
This protective effect is achieved through different mechanisms including enhanced remyelination, reversal of synaptic and cognitive …
50 results