Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 2
2006 3
2007 2
2010 1
2011 1
2012 3
2013 3
2015 1
2016 1
2017 1
2018 2
2019 2
2020 4
2021 2
2022 7
2023 9
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

40 results

Results by year

Filters applied: . Clear all
Page 1
Microglia regulate central nervous system myelin growth and integrity.
McNamara NB, Munro DAD, Bestard-Cuche N, Uyeda A, Bogie JFJ, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJA, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE. McNamara NB, et al. Among authors: bogie jfj, hendriks jja. Nature. 2023 Jan;613(7942):120-129. doi: 10.1038/s41586-022-05534-y. Epub 2022 Dec 14. Nature. 2023. PMID: 36517604 Free PMC article.
We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte state with altered lipid metabolism. Moreover, this mechanism is regulated through disruption of the TGFbeta1-TGFbetaR1 axis. ...
We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte …
Perilipin-2 limits remyelination by preventing lipid droplet degradation.
Loix M, Wouters E, Vanherle S, Dehairs J, McManaman JL, Kemps H, Swinnen JV, Haidar M, Bogie JFJ, Hendriks JJA. Loix M, et al. Among authors: bogie jfj, hendriks jja. Cell Mol Life Sci. 2022 Sep 13;79(10):515. doi: 10.1007/s00018-022-04547-0. Cell Mol Life Sci. 2022. PMID: 36100764
Accordingly, loss of Plin2 stimulates LD turnover in foamy phagocytes, driving them towards a less inflammatory phenotype. Importantly, Plin2-deficiency markedly improves remyelination in the ex vivo brain slice model and in the in vivo cuprizone-induced demyelination mode …
Accordingly, loss of Plin2 stimulates LD turnover in foamy phagocytes, driving them towards a less inflammatory phenotype. Importantly, Plin …
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, Gervois P, Wolfs E, Lambrichts I, Brullo C, Bruno O, Fedele E, Ricciarelli R, Ffrench-Constant C, Bechler ME, van Schaik P, Baron W, Lefevere E, Wasner K, Grünewald A, Verfaillie C, Baeten P, Broux B, Wieringa P, Hellings N, Prickaerts J, Vanmierlo T. Schepers M, et al. Among authors: vanmierlo t, hellings n. Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020. Epub 2022 Dec 28. Brain Behav Immun. 2023. PMID: 36584795 Free article.
More specifically, we segregated the myelination-promoting and anti-inflammatory effects into a PDE4D- and PDE4B-dependent process respectively. We show that inhibition of PDE4D boosts oligodendrocyte progenitor cells (OPC) differentiation and enhances (re)myelination of b …
More specifically, we segregated the myelination-promoting and anti-inflammatory effects into a PDE4D- and PDE4B-dependent process respectiv …
Targeting lipophagy in macrophages improves repair in multiple sclerosis.
Haidar M, Loix M, Vanherle S, Dierckx T, Vangansewinkel T, Gervois P, Wolfs E, Lambrichts I, Bogie JFJ, Hendriks JJA. Haidar M, et al. Among authors: bogie jfj, hendriks jja. Autophagy. 2022 Nov;18(11):2697-2710. doi: 10.1080/15548627.2022.2047343. Epub 2022 Mar 14. Autophagy. 2022. PMID: 35282773 Free PMC article.
Stimulating autophagy using the natural disaccharide trehalose reduced the lipid load and inflammatory phenotype of myelin-laden macrophages. Importantly, trehalose was able to boost remyelination in the ex vivo brain slice model and the in vivo cuprizone-induced demyelina …
Stimulating autophagy using the natural disaccharide trehalose reduced the lipid load and inflammatory phenotype of myelin-laden macrophages …
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.
Bogie JFJ, Grajchen E, Wouters E, Corrales AG, Dierckx T, Vanherle S, Mailleux J, Gervois P, Wolfs E, Dehairs J, Van Broeckhoven J, Bowman AP, Lambrichts I, Gustafsson JÅ, Remaley AT, Mulder M, Swinnen JV, Haidar M, Ellis SR, Ntambi JM, Zelcer N, Hendriks JJA. Bogie JFJ, et al. Among authors: hendriks jja. J Exp Med. 2020 May 4;217(5):e20191660. doi: 10.1084/jem.20191660. J Exp Med. 2020. PMID: 32097464 Free PMC article.
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. ...Pharmacological inhibition or phagocyte-specific deficiency of Scd1 accelerated remyelination ex vivo and in vivo. These findings identify SCD1 as a no …
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. ...Pharmacological in …
From OPC to Oligodendrocyte: An Epigenetic Journey.
Tiane A, Schepers M, Rombaut B, Hupperts R, Prickaerts J, Hellings N, van den Hove D, Vanmierlo T. Tiane A, et al. Among authors: vanmierlo t, hellings n. Cells. 2019 Oct 11;8(10):1236. doi: 10.3390/cells8101236. Cells. 2019. PMID: 31614602 Free PMC article. Review.
Oligodendrocytes need to be newly formed from a pool of oligodendrocyte precursor cells (OPCs). The differentiation of OPCs into mature and myelinating cells is a multistep process, tightly controlled by spatiotemporal activation and repression of specific growth and trans …
Oligodendrocytes need to be newly formed from a pool of oligodendrocyte precursor cells (OPCs). The differentiation of OPCs into matu …
Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation.
Dierckx T, Vanherle S, Haidar M, Grajchen E, Mingneau F, Gervois P, Wolfs E, Bylemans D, Voet A, Nguyen T, Hamad I, Kleinewietfeld M, Bogie JFJ, Hendriks JJA. Dierckx T, et al. Among authors: bogie jfj, hendriks jja. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2120393119. doi: 10.1073/pnas.2120393119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343243 Free PMC article.
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. ...Previously, we found that phloretin, a flavonoid abundantly present in apples and strawberries, reduces neuroinflammation by driving macrophages toward an ant …
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. ...Previously, we fou …
Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis.
Spaas J, Van der Stede T, de Jager S, van de Waterweg Berends A, Tiane A, Baelde H, Baba SP, Eckhardt M, Wolfs E, Vanmierlo T, Hellings N, Eijnde BO, Derave W. Spaas J, et al. Among authors: vanmierlo t, hellings n. Prog Neurobiol. 2023 Dec;231:102532. doi: 10.1016/j.pneurobio.2023.102532. Epub 2023 Sep 27. Prog Neurobiol. 2023. PMID: 37774767
Multiple sclerosis (MS) pathology features autoimmune-driven neuroinflammation, demyelination, and failed remyelination. Carnosine is a histidine-containing dipeptide (HCD) with pluripotent homeostatic properties that is able to improve outcomes in an animal MS model (EAE) …
Multiple sclerosis (MS) pathology features autoimmune-driven neuroinflammation, demyelination, and failed remyelination. Carnosine is …
From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions.
Tiane A, Schepers M, Reijnders RA, van Veggel L, Chenine S, Rombaut B, Dempster E, Verfaillie C, Wasner K, Grünewald A, Prickaerts J, Pishva E, Hellings N, van den Hove D, Vanmierlo T. Tiane A, et al. Among authors: vanmierlo t, hellings n. Acta Neuropathol. 2023 Aug;146(2):283-299. doi: 10.1007/s00401-023-02596-8. Epub 2023 Jun 7. Acta Neuropathol. 2023. PMID: 37286732 Free PMC article.
In the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have previously shown that DNA methylation of Id2/Id4 is highly involved in OPC diffe …
In the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of oligodendrocyte precursor cells (OPCs) …
40 results