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Glial regulation of the blood-brain barrier in health and disease.
Broux B, Gowing E, Prat A. Broux B, et al. Semin Immunopathol. 2015 Nov;37(6):577-90. doi: 10.1007/s00281-015-0516-2. Epub 2015 Aug 6. Semin Immunopathol. 2015. PMID: 26245144 Review.
Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and toxins. The blood-brain barrier (BBB) is very tightly regulated by specialized endothelial cells, two basement membran …
Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and …
Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
Hermans D, Houben E, Baeten P, Slaets H, Janssens K, Hoeks C, Hosseinkhani B, Duran G, Bormans S, Gowing E, Hoornaert C, Beckers L, Fung WK, Schroten H, Ishikawa H, Fraussen J, Thoelen R, de Vries HE, Kooij G, Zandee S, Prat A, Hellings N, Broux B. Hermans D, et al. Among authors: broux b. Acta Neuropathol. 2022 Aug;144(2):259-281. doi: 10.1007/s00401-022-02445-0. Epub 2022 Jun 6. Acta Neuropathol. 2022. PMID: 35666306
Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood - brain barrier function.
Hosseinkhani B, Duran G, Hoeks C, Hermans D, Schepers M, Baeten P, Poelmans J, Coenen B, Bekar K, Pintelon I, Timmermans JP, Vanmierlo T, Michiels L, Hellings N, Broux B. Hosseinkhani B, et al. Among authors: broux b. Fluids Barriers CNS. 2023 Dec 19;20(1):95. doi: 10.1186/s12987-023-00504-6. Fluids Barriers CNS. 2023. PMID: 38114994 Free PMC article.
Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial role in the initiation of demyelination and neurodegeneration in multiple sclerosis (MS). ...
Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial …
Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs.
Baeten P, Hamad I, Hoeks C, Hiltensperger M, Van Wijmeersch B, Popescu V, Aly L, Somers V, Korn T, Kleinewietfeld M, Hellings N, Broux B. Baeten P, et al. Among authors: broux b. JCI Insight. 2024 Apr 8;9(7):e167457. doi: 10.1172/jci.insight.167457. JCI Insight. 2024. PMID: 38386413 Free PMC article.
In a human in vitro model, we discovered that interaction with inflamed blood-brain barrier endothelial cells (BBB-ECs) induces loss of function by Tregs. ...
In a human in vitro model, we discovered that interaction with inflamed blood-brain barrier endothelial cells (BBB-ECs) …
Regulatory T cell therapy for multiple sclerosis: Breaching (blood-brain) barriers.
Verreycken J, Baeten P, Broux B. Verreycken J, et al. Among authors: broux b. Hum Vaccin Immunother. 2022 Dec 30;18(7):2153534. doi: 10.1080/21645515.2022.2153534. Epub 2022 Dec 28. Hum Vaccin Immunother. 2022. PMID: 36576251 Free PMC article. Review.
However, to perform their local anti-inflammatory and regenerative functions in the brain, they must first migrate across the blood-brain barrier (BBB). This review summarizes the reported results concerning the migration of Tregs across the BBB and the influ …
However, to perform their local anti-inflammatory and regenerative functions in the brain, they must first migrate across the blood- …
EGFL7 reduces CNS inflammation in mouse.
Larochelle C, Uphaus T, Broux B, Gowing E, Paterka M, Michel L, Dudvarski Stankovic N, Bicker F, Lemaître F, Prat A, Schmidt MHH, Zipp F. Larochelle C, et al. Among authors: broux b. Nat Commun. 2018 Feb 26;9(1):819. doi: 10.1038/s41467-018-03186-z. Nat Commun. 2018. PMID: 29483510 Free PMC article.
Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) are implicated in cell trafficking. ...
Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) are implicated in cel …
Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4+ T cells with brain-homing capacity.
Hoeks C, Puijfelik FV, Koetzier SC, Rip J, Corsten CEA, Wierenga-Wolf AF, Melief MJ, Stinissen P, Smolders J, Hellings N, Broux B, van Luijn MM. Hoeks C, et al. Among authors: broux b. Eur J Immunol. 2024 Feb;54(2):e2350544. doi: 10.1002/eji.202350544. Epub 2023 Dec 7. Eur J Immunol. 2024. PMID: 38009648
Under steady-state conditions, granzyme K(high) Th17.1 cells spontaneously passed the blood-brain barrier in vitro. This was only found for other subsets including CD28(-) cells when using inflamed barriers. Altogether, CD4(+) T cells contain small fractions …
Under steady-state conditions, granzyme K(high) Th17.1 cells spontaneously passed the blood-brain barrier in vitro. Thi …
Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function.
Broux B, Zandee S, Gowing E, Charabati M, Lécuyer MA, Tastet O, Hachehouche L, Bourbonnière L, Ouimet JP, Lemaitre F, Larouche S, Cayrol R, Bouthillier A, Moumdjian R, Lahav B, Poirier J, Duquette P, Arbour N, Peelen E, Prat A. Broux B, et al. Neurol Neuroimmunol Neuroinflamm. 2020 Aug 11;7(6):e870. doi: 10.1212/NXI.0000000000000870. Print 2020 Nov. Neurol Neuroimmunol Neuroinflamm. 2020. PMID: 32788322 Free PMC article.
OBJECTIVE: To investigate the involvement of interleukin (IL)-26 in neuroinflammatory processes in multiple sclerosis (MS), in particular in blood-brain barrier (BBB) integrity. METHODS: Expression of IL-26 was measured in serum, CSF, in vitro differentiated …
OBJECTIVE: To investigate the involvement of interleukin (IL)-26 in neuroinflammatory processes in multiple sclerosis (MS), in particular in …
EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Luo H, Broux B, Wang X, Hu Y, Ghannam S, Jin W, Larochelle C, Prat A, Wu J. Luo H, et al. Among authors: broux b. Neurobiol Dis. 2016 Jul;91:292-306. doi: 10.1016/j.nbd.2016.03.013. Epub 2016 Mar 30. Neurobiol Dis. 2016. PMID: 27039370
Reverse signaling through EFNB1 and EFNB2 in human Th17 cells enhances their migration through a monolayer of blood brain barrier endothelial cells. Our study demonstrates that expression of EFNB1 and EFNB2 is implicated in Th cell differentiation and migrati …
Reverse signaling through EFNB1 and EFNB2 in human Th17 cells enhances their migration through a monolayer of blood brain b …