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IRBIT activates NBCe1-B by releasing the auto-inhibition module from the transmembrane domain.
Su P, Wu H, Wang M, Cai L, Liu Y, Chen LM. Su P, et al. J Physiol. 2021 Feb;599(4):1151-1172. doi: 10.1113/JP280578. Epub 2020 Dec 9. J Physiol. 2021. PMID: 33237573 Free PMC article.
KEY POINTS: The electrogenic Na(+) /HCO(3)(-) cotransporter NBCe1-B is widely expressed in many tissues, including pancreas, submandibular gland, brain, heart, etc. NBCe1-B has very low activity under basal condition due to auto-inhibition, but can be fully activated by pr …
KEY POINTS: The electrogenic Na(+) /HCO(3)(-) cotransporter NBCe1-B is widely expressed in many tissues, including pancreas, submandibular g …
Protein interactions of the vesicular glutamate transporter VGLUT1.
Santos MS, Foss SM, Park CK, Voglmaier SM. Santos MS, et al. PLoS One. 2014 Oct 15;9(10):e109824. doi: 10.1371/journal.pone.0109824. eCollection 2014. PLoS One. 2014. PMID: 25334008 Free PMC article.
While the C-termini of VGLUT1 and 2 share a dileucine-like trafficking motif and a proline-, glutamate-, serine-, and threonine-rich PEST domain, only VGLUT1 contains two polyproline domains and a phosphorylation consensus sequence in a region of acidic amino acids. …
While the C-termini of VGLUT1 and 2 share a dileucine-like trafficking motif and a proline-, glutamate-, serine-, and threonine-rich PEST …
Oxidative stress reduces levels of dysbindin-1A via its PEST domain.
Yap MY, Lo YL, Talbot K, Ong WY. Yap MY, et al. Neurochem Int. 2014 Dec;79:65-9. doi: 10.1016/j.neuint.2014.10.001. Epub 2014 Oct 31. Neurochem Int. 2014. PMID: 25445987
The present study tests the hypothesis that oxidative stress can affect levels of dysbindin-1A, encoded by Dtnbp1, a genetic risk factor for schizophrenia, via its PEST domain. In vitro studies on SH-SY5Y cells indicate that oxidative stress triggers proteasomal deg …
The present study tests the hypothesis that oxidative stress can affect levels of dysbindin-1A, encoded by Dtnbp1, a genetic risk factor for …
Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells.
Sacchi N, Tamanini F, Willemsen R, Denis-Donini S, Campiglio S, Hoogeveen AT. Sacchi N, et al. Oncogene. 1998 May;16(20):2609-15. doi: 10.1038/sj.onc.1201824. Oncogene. 1998. PMID: 9632137
The predicted protein sequence shows two unusual, putative zinc-fingers, three proline-rich regions, a PEST domain and several phosphorylation sites. In addition, we found a region encompassing aa 443-514 predicted to have a significant propensity to form coiled coi …
The predicted protein sequence shows two unusual, putative zinc-fingers, three proline-rich regions, a PEST domain and several …
Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.
Arruga F, Gizdic B, Bologna C, Cignetto S, Buonincontri R, Serra S, Vaisitti T, Gizzi K, Vitale N, Garaffo G, Mereu E, Diop F, Neri F, Incarnato D, Coscia M, Allan J, Piva R, Oliviero S, Furman RR, Rossi D, Gaidano G, Deaglio S. Arruga F, et al. Leukemia. 2017 Sep;31(9):1882-1893. doi: 10.1038/leu.2016.383. Epub 2016 Dec 26. Leukemia. 2017. PMID: 28017968 Free article.
Specifically, NOTCH1 affects the methylation of DUSP22 promoter by modulating a nuclear complex, which tunes the activity of DNA methyltransferase 3A (DNMT3A). These effects are enhanced by PEST-domain mutations, which stabilize the molecule and prolong signaling. . …
Specifically, NOTCH1 affects the methylation of DUSP22 promoter by modulating a nuclear complex, which tunes the activity of DNA methyltrans …
Identification and functional characterization of zebrafish solute carrier Slc16a2 (Mct8) as a thyroid hormone membrane transporter.
Arjona FJ, de Vrieze E, Visser TJ, Flik G, Klaren PH. Arjona FJ, et al. Endocrinology. 2011 Dec;152(12):5065-73. doi: 10.1210/en.2011-1166. Epub 2011 Sep 27. Endocrinology. 2011. PMID: 21952246
The 526-amino-acid sequence contains 12 predicted transmembrane domains. An intracellular N-terminal PEST domain, thought to be involved in proteolytic processing of the protein, is present in the zebrafish sequence. ...When measured at 37 C, zebrafish Slc16a2 trans …
The 526-amino-acid sequence contains 12 predicted transmembrane domains. An intracellular N-terminal PEST domain, thought to b …
A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.
Nelson RF, Glenn KA, Miller VM, Wen H, Paulson HL. Nelson RF, et al. J Biol Chem. 2006 Jul 21;281(29):20242-51. doi: 10.1074/jbc.M602423200. Epub 2006 May 8. J Biol Chem. 2006. PMID: 16682404 Free article.
Only in fully assembled SCF complexes, it is believed, can substrates bound to F-box proteins become ubiquitinated. Here we show that Fbx2, a brain-enriched F-box protein implicated in the ubiquitination of glycoproteins discarded from the endoplasmic reticulum, binds the …
Only in fully assembled SCF complexes, it is believed, can substrates bound to F-box proteins become ubiquitinated. Here we show that Fbx2, …
Proteolytic processing of beta-amyloid precursor by calpain I.
Siman R, Card JP, Davis LG. Siman R, et al. J Neurosci. 1990 Jul;10(7):2400-11. doi: 10.1523/JNEUROSCI.10-07-02400.1990. J Neurosci. 1990. PMID: 2115911 Free PMC article.
Immunoblotting with a specific APP antiserum was used to assess the in vitro degradation of rat brain APP, which appears as a triplet of polypeptides of Mr 110-130 kDa. ...The most protease-sensitive site was located within the highly acidic structural motif called the …
Immunoblotting with a specific APP antiserum was used to assess the in vitro degradation of rat brain APP, which appears as a triplet …