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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2003 3
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2006 1
2007 1
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2009 3
2010 1
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2012 2
2013 3
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2018 3
2020 1
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Page 1
Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.
Tripathi R, Fiore LS, Richards DL, Yang Y, Liu J, Wang C, Plattner R. Tripathi R, et al. Among authors: plattner r. Sci Signal. 2018 Feb 20;11(518):eaao0422. doi: 10.1126/scisignal.aao0422. Sci Signal. 2018. PMID: 29463776 Free PMC article.
As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated in primary melanomas, and Abl/Arg-driven invasion in culture and metastasis in vivo required cathepsin secretion. These data suggest …
As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated …
Abl kinase regulation by BRAF/ERK and cooperation with Akt in melanoma.
Jain A, Tripathi R, Turpin CP, Wang C, Plattner R. Jain A, et al. Among authors: plattner r. Oncogene. 2017 Aug 10;36(32):4585-4596. doi: 10.1038/onc.2017.76. Epub 2017 Apr 3. Oncogene. 2017. PMID: 28368422 Free PMC article.
In particular, melanomas harboring BRAF(V600E) and PTEN mutations often are resistant to current therapies, including BRAF inhibitors (BRAFi) and immune checkpoint inhibitors. Abl kinases (Abl/Arg) are activated in melanomas and drive progression; however, their mec …
In particular, melanomas harboring BRAF(V600E) and PTEN mutations often are resistant to current therapies, including BRAF inhibitors (BRAFi …
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.
Plattner R, Kadlec L, DeMali KA, Kazlauskas A, Pendergast AM. Plattner R, et al. Genes Dev. 1999 Sep 15;13(18):2400-11. doi: 10.1101/gad.13.18.2400. Genes Dev. 1999. PMID: 10500097 Free PMC article.
The c-Abl tyrosine kinase localizes to the cytoplasm and plasma membrane in addition to the nucleus. ...We found that c-Abl kinase activity was increased by 10- to 20-fold in these cells, and that Src and Fyn kinases directly phosphorylated c-Abl in vitro. .. …
The c-Abl tyrosine kinase localizes to the cytoplasm and plasma membrane in addition to the nucleus. ...We found that c-Abl ki …
c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.
Fiore LS, Ganguly SS, Sledziona J, Cibull ML, Wang C, Richards DL, Neltner JM, Beach C, McCorkle JR, Kaetzel DM, Plattner R. Fiore LS, et al. Among authors: plattner r. Oncogene. 2014 Sep 4;33(36):4508-4520. doi: 10.1038/onc.2013.399. Epub 2013 Oct 7. Oncogene. 2014. PMID: 24096484 Free PMC article.
Moreover, c-Abl activates cathepsins by promoting endosome maturation, which facilitates trafficking of NM23-H1 to the lysosome where it is degraded. Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM …
Moreover, c-Abl activates cathepsins by promoting endosome maturation, which facilitates trafficking of NM23-H1 to the lysosome where …
c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.
Ganguly SS, Fiore LS, Sims JT, Friend JW, Srinivasan D, Thacker MA, Cibull ML, Wang C, Novak M, Kaetzel DM, Plattner R. Ganguly SS, et al. Among authors: plattner r. Oncogene. 2012 Apr 5;31(14):1804-16. doi: 10.1038/onc.2011.361. Epub 2011 Sep 5. Oncogene. 2012. PMID: 21892207 Free PMC article.
Most importantly, c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo, as inhibition of c-Abl/Arg kinase activity with the c-Abl/Arg inhibitor, nilotinib, dramatically inhibits metastasis i …
Most importantly, c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis i …
Reciprocal regulation of Abl and receptor tyrosine kinases.
Srinivasan D, Kaetzel DM, Plattner R. Srinivasan D, et al. Among authors: plattner r. Cell Signal. 2009 Jul;21(7):1143-50. doi: 10.1016/j.cellsig.2009.03.003. Epub 2009 Mar 9. Cell Signal. 2009. PMID: 19275932 Free PMC article.
In this study, we show that Abl kinase SH2 domains bind directly to Her-2, and like PDGFR-beta , Her-2 directly phosphorylates c-Abl. ...Here, we show that PDGFR-beta-phosphorylation of Abl kinases has functional consequences as PDGFR-beta phosphorylates A …
In this study, we show that Abl kinase SH2 domains bind directly to Her-2, and like PDGFR-beta , Her-2 directly phosphorylates c-A …
EnABLing Cathepsin-Driven Melanoma Metastasis.
Tripathi R, Plattner R. Tripathi R, et al. Among authors: plattner r. Mol Cell Oncol. 2018 Aug 17;5(4):e1458016. doi: 10.1080/23723556.2018.1458016. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250913 Free PMC article.
Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as …
Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce …
EnABLing Tumor Growth and Progression: Recent progress in unraveling the functions of ABL kinases in solid tumor cells.
Tripathi R, Liu Z, Plattner R. Tripathi R, et al. Among authors: plattner r. Curr Pharmacol Rep. 2018 Oct;4(5):367-379. doi: 10.1007/s40495-018-0149-y. Epub 2018 Jul 23. Curr Pharmacol Rep. 2018. PMID: 30746323 Free PMC article.
In some tumor types, the kinases may act to integrate pro- and anti-proliferative and -invasive signals, and also may serve as a switch during EMT/MET (mesenchymal-epithelial) transitions. CONCLUSIONS: Most data indicate that targeting ABL kinases may be effective for redu …
In some tumor types, the kinases may act to integrate pro- and anti-proliferative and -invasive signals, and also may serve as a switch duri …
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham RT, York JD, Pendergast AM. Plattner R, et al. Nat Cell Biol. 2003 Apr;5(4):309-19. doi: 10.1038/ncb949. Nat Cell Biol. 2003. PMID: 12652307
However, the activity of Src kinases alone is not sufficient for activation of c-Abl by PDGFR. Here we show that functional phospholipase C-gamma1 (PLC-gamma1) is required for c-Abl activation by PDGFR. ...PLC-gamma1 and c-Abl form a complex in cells that is …
However, the activity of Src kinases alone is not sufficient for activation of c-Abl by PDGFR. Here we show that functional phospholi …
Activation of abl family kinases in solid tumors.
Ganguly SS, Plattner R. Ganguly SS, et al. Among authors: plattner r. Genes Cancer. 2012 May;3(5-6):414-25. doi: 10.1177/1947601912458586. Genes Cancer. 2012. PMID: 23226579 Free PMC article.
Furthermore, c-Abl/Arg inhibitors have been used in numerous solid tumor clinical trials; however, none of these trials were restricted to patients whose tumors expressed highly activated c-Abl/Arg (targeted trial). Targeted trials are critical for determining wheth …
Furthermore, c-Abl/Arg inhibitors have been used in numerous solid tumor clinical trials; however, none of these trials were restrict …
22 results