Enantiospecificity of glutamate carboxypeptidase II inhibition.
Tsukamoto T, Majer P, Vitharana D, Ni C, Hin B, Lu XC, Thomas AG, Wozniak KM, Calvin DC, Wu Y, Slusher BS, Scarpetti D, Bonneville GW.
Tsukamoto T, et al.
J Med Chem. 2005 Apr 7;48(7):2319-24. doi: 10.1021/jm049258g.
J Med Chem. 2005.
PMID: 15801825
The two enantiomers of 2 were prepared from previously reported chiral intermediates, (R)- and (S)-2-(hydroxyphosphinoylmethyl)pentanedioic acid benzyl esters 8. The synthesis of (R)- and (S)-3 involves the hydrolysis of (R)- and (S)-3-(2 …
The two enantiomers of 2 were prepared from previously reported chiral intermediates, (R)- and (S)-2-(hydroxyphosphinoylmethyl)pentan …