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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1998 1
2000 2
2001 1
2002 3
2003 3
2004 1
2005 5
2006 6
2007 7
2008 4
2009 6
2010 4
2011 7
2012 4
2013 6
2014 8
2015 7
2016 14
2017 9
2018 8
2019 1
2020 8
2021 7
2022 10
2023 10
2024 5

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132 results

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Page 1
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL. Thenappan T, et al. BMJ. 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. BMJ. 2018. PMID: 29540357 Free PMC article. Review.
Progress has been made in identifying the causes of PAH and approving new drug therapies. A cancer-like increase in cell proliferation and resistance to apoptosis reflects acquired abnormalities of mitochondrial metabolism and dynamics. ...Complex changes in cyto …
Progress has been made in identifying the causes of PAH and approving new drug therapies. A cancer-like increase in cell proliferatio …
Deucravacitinib for the Treatment of Psoriatic Disease.
Lé AM, Puig L, Torres T. Lé AM, et al. Am J Clin Dermatol. 2022 Nov;23(6):813-822. doi: 10.1007/s40257-022-00720-0. Epub 2022 Aug 12. Am J Clin Dermatol. 2022. PMID: 35960487 Free PMC article. Review.
Tyrosine kinase 2 (TYK2) is responsible for mediating immune signalling of IL-12, IL-23 and type I interferons, without interfering with other critical systemic functions as other JAK proteins do. ...There were no reports of serious infections, thromboembolic events, or la …
Tyrosine kinase 2 (TYK2) is responsible for mediating immune signalling of IL-12, IL-23 and type I interferons, without interfering w …
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease.
Shen S, Liao Q, Wong YK, Chen X, Yang C, Xu C, Sun J, Wang J. Shen S, et al. Int J Biol Sci. 2022 Jan 1;18(3):983-994. doi: 10.7150/ijbs.66871. eCollection 2022. Int J Biol Sci. 2022. PMID: 35173531 Free PMC article. Review.
In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal protein processing, oxidative stress and proinflammatory cytokines will drive the activation of inflammatory pathways, leading to low-grade chronic inflammation and insulin resis …
In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal protein processing, oxidative stress and proi …
The Role of Maternal Immune Activation in the Pathogenesis of Autism: A Review of the Evidence, Proposed Mechanisms and Implications for Treatment.
Zawadzka A, Cieślik M, Adamczyk A. Zawadzka A, et al. Int J Mol Sci. 2021 Oct 26;22(21):11516. doi: 10.3390/ijms222111516. Int J Mol Sci. 2021. PMID: 34768946 Free PMC article. Review.
Infection during pregnancy activates the mother's immune system to release proinflammatory cytokines, such as IL-6, TNF-alpha, and others. Furthermore, these cytokines can directly cross the placenta and enter the fetal circulation, or activate resident immune cells …
Infection during pregnancy activates the mother's immune system to release proinflammatory cytokines, such as IL-6, TNF-alpha, and ot …
Molecular Mechanisms and Management of a Cutaneous Inflammatory Disorder: Psoriasis.
Woo YR, Cho DH, Park HJ. Woo YR, et al. Int J Mol Sci. 2017 Dec 11;18(12):2684. doi: 10.3390/ijms18122684. Int J Mol Sci. 2017. PMID: 29232931 Free PMC article. Review.
Among diverse aberrant immunopathogenetic mechanisms, the current model emphasizes the role of Th1 and the IL-23/Th17 axis, skin-resident immune cells and major signal transduction pathways involved in psoriasis. The multiple genetic risk loci for psoriasis have bee …
Among diverse aberrant immunopathogenetic mechanisms, the current model emphasizes the role of Th1 and the IL-23/Th17 axis, skin-resident im …
Low-Dose IL-2 in the Treatment of Lupus.
Mizui M, Tsokos GC. Mizui M, et al. Curr Rheumatol Rep. 2016 Nov;18(11):68. doi: 10.1007/s11926-016-0617-5. Curr Rheumatol Rep. 2016. PMID: 27734211 Review.
In SLE, T cells show aberrant function such as deficient IL-2 production and abnormal signaling events. Expansion of Treg by IL-2 represents a specific strategy to control self-tolerance; however, restoration of abnormal immune function and responses should b …
In SLE, T cells show aberrant function such as deficient IL-2 production and abnormal signaling events. Expansion of Treg by I …
Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases.
Jiang J, Zhao M, Chang C, Wu H, Lu Q. Jiang J, et al. Clin Rev Allergy Immunol. 2020 Oct;59(2):248-272. doi: 10.1007/s12016-020-08798-2. Clin Rev Allergy Immunol. 2020. PMID: 32557263 Review.
Furthermore, both interventions in animal models and clinical trials of therapies targeting the type I IFN signaling pathway have shown efficacy in the treatment of autoimmune diseases. Our review aims to summarize the functions and targeted therapies (as wel …
Furthermore, both interventions in animal models and clinical trials of therapies targeting the type I IFN signaling pathway h …
Management of myelofibrosis: JAK inhibition and beyond.
Stahl M, Zeidan AM. Stahl M, et al. Expert Rev Hematol. 2017 May;10(5):459-477. doi: 10.1080/17474086.2017.1317590. Epub 2017 Apr 26. Expert Rev Hematol. 2017. PMID: 28395559 Review.
Myelofibrosis (MF) is characterized by bone marrow fibrosis with subsequent extramedullary hematopoiesis and abnormal cytokine expression leading to splenomegaly, constitutional symptoms and cytopenias. ...Finally, we review novel therapeutic options for MF i …
Myelofibrosis (MF) is characterized by bone marrow fibrosis with subsequent extramedullary hematopoiesis and abnormal cytokine …
Implantation failure: molecular mechanisms and clinical treatment.
Cakmak H, Taylor HS. Cakmak H, et al. Hum Reprod Update. 2011 Mar-Apr;17(2):242-53. doi: 10.1093/humupd/dmq037. Epub 2010 Aug 21. Hum Reprod Update. 2011. PMID: 20729534 Free PMC article. Review.
RESULTS: The absence or suppression of molecules essential for endometrial receptivity results in decreased implantation rates in animal models and gynecological diseases, including endometriosis, hydrosalpinx, leiomyoma and polycystic ovarian syndrome. The mechanisms are diverse …
RESULTS: The absence or suppression of molecules essential for endometrial receptivity results in decreased implantation rates in animal mod …
Current insights and future prospects for the pathogenesis and treatment for rheumatoid arthritis.
Koga T, Kawakami A, Tsokos GC. Koga T, et al. Clin Immunol. 2021 Apr;225:108680. doi: 10.1016/j.clim.2021.108680. Epub 2021 Jan 23. Clin Immunol. 2021. PMID: 33493672 Review.
Genetic, environmental, and epigenetic factors simultaneously or serially contribute to immune cells and resident joint tissue cell abnormalities, invariably leading to joint destruction. Understanding the immune cell dysfunction in earlier years has brought forward life-c …
Genetic, environmental, and epigenetic factors simultaneously or serially contribute to immune cells and resident joint tissue cell abnor …
132 results