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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1995 1
1996 2
1997 1
2001 1
2003 2
2005 1
2006 2
2009 1
2010 2
2011 6
2012 1
2013 5
2014 4
2015 2
2016 2
2017 2
2018 4
2020 2
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2024 1

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41 results

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Page 1
Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.
Vahlquist A, Fischer J, Törmä H. Vahlquist A, et al. Am J Clin Dermatol. 2018 Feb;19(1):51-66. doi: 10.1007/s40257-017-0313-x. Am J Clin Dermatol. 2018. PMID: 28815464 Free PMC article. Review.
Hereditary ichthyoses are due to mutations on one or both alleles of more than 30 different genes, mainly expressed in the upper epidermis. Syndromic as well as nonsyndromic forms of ichthyosis exist. ...In nonsyndromic forms, these features are most evident in seve …
Hereditary ichthyoses are due to mutations on one or both alleles of more than 30 different genes, mainly expressed in the upper e …
Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment.
Hailing T, Yonghong P, Yufeng Z, Haitao T. Hailing T, et al. J Control Release. 2022 Sep;349:592-605. doi: 10.1016/j.jconrel.2022.07.018. Epub 2022 Jul 22. J Control Release. 2022. PMID: 35872181 Review.
Its over-expression and mutation status can be served as a biomarker to identify patients who can be benifit from EGFR tyrosine kinase inhibitors and anti-EGFR monocloncal antibody (mAb) therapy. For decades, researches on EGFR targeted ligands were actively carried …
Its over-expression and mutation status can be served as a biomarker to identify patients who can be benifit from EGFR tyrosine kinas …
EGFR Signaling Is Overactive in Pachyonychia Congenita: Effective Treatment with Oral Erlotinib.
Basset J, Marchal L, Hovnanian A. Basset J, et al. J Invest Dermatol. 2023 Feb;143(2):294-304.e8. doi: 10.1016/j.jid.2022.08.045. Epub 2022 Sep 16. J Invest Dermatol. 2023. PMID: 36116508 Free article.
PC is caused by dominant mutations in keratin (K) K6A, K6B, K6C, K16, or K17 genes involved in stress, wound healing, and epidermal barrier formation. Mechanisms leading to pain and painful palmoplantar keratoderma in PC remain elusive. ...EGFR activation was confirmed by …
PC is caused by dominant mutations in keratin (K) K6A, K6B, K6C, K16, or K17 genes involved in stress, wound healing, and epidermal b …
ALK inhibitors in the treatment of advanced NSCLC.
Gridelli C, Peters S, Sgambato A, Casaluce F, Adjei AA, Ciardiello F. Gridelli C, et al. Cancer Treat Rev. 2014 Mar;40(2):300-6. doi: 10.1016/j.ctrv.2013.07.002. Epub 2013 Aug 7. Cancer Treat Rev. 2014. PMID: 23931927 Review.
Currently, the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) represent the standard of care for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring activating EGFR mutations. ...Among these rare genet …
Currently, the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) represent the standard of care for pa …
New molecular targets in the treatment of NSCLC.
Schettino C, Bareschino MA, Sacco PC, Maione P, Rossi A, Casaluce F, Sgambato A, Gridelli C. Schettino C, et al. Curr Pharm Des. 2013;19(30):5333-43. doi: 10.2174/13816128113199990343. Curr Pharm Des. 2013. PMID: 23394083 Review.
Advances in understanding of the molecular pathogenesis of lung cancer have led to the identification of several specific targets for therapeutic agents. Targeting the epidermal growth factor receptor (EGFR) has played a central role in advancing NSCLC research, tre …
Advances in understanding of the molecular pathogenesis of lung cancer have led to the identification of several specific targets for the …
Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis.
Yadav K, Singh D, Singh MR. Yadav K, et al. Int J Biol Macromol. 2018 Oct 15;118(Pt B):1796-1810. doi: 10.1016/j.ijbiomac.2018.07.021. Epub 2018 Jul 11. Int J Biol Macromol. 2018. PMID: 30017989 Review.
It consents to multifaceted and discrete pathology due to the genetic and immunological alteration resulting from abnormal expression of various regulatory and structural proteins. These proteins are associated with various cellular and sub-cellular ac …
It consents to multifaceted and discrete pathology due to the genetic and immunological alteration resulting from abnormal express …
Ceramide Analysis in Combination With Genetic Testing May Provide a Precise Diagnosis for Self-Healing Collodion Babies.
Takeichi T, Ohno Y, Tanahashi K, Ito Y, Shiraishi K, Utsunomiya R, Yoshida S, Ikeda K, Nomura H, Morizane S, Sayama K, Ogi T, Muro Y, Kihara A, Akiyama M. Takeichi T, et al. J Lipid Res. 2022 Dec;63(12):100308. doi: 10.1016/j.jlr.2022.100308. Epub 2022 Nov 1. J Lipid Res. 2022. PMID: 36332686 Free PMC article.
However, during the neonatal period, it is not easy to distinguish SHCB from other inflammatory forms of autosomal recessive congenital ichthyosis, such as congenital ichthyosiform erythroderma. ...CYP4F22 is an ultra-long-chain FA omega-hydroxylase responsible for …
However, during the neonatal period, it is not easy to distinguish SHCB from other inflammatory forms of autosomal recessive congenital …
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer.
Mendelsohn J, Baselga J. Mendelsohn J, et al. J Clin Oncol. 2003 Jul 15;21(14):2787-99. doi: 10.1200/JCO.2003.01.504. J Clin Oncol. 2003. PMID: 12860957 Review.
The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family that is abnormally activated in many epithelial tumors. ...Taken together, these observations indicate that the EGFR is a promising target for cancer therapy. Monoclo …
The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family that is abnormally activated in m …
Disturbed keratin expression and distinct genotype of ichthyosis hystrix Lambert type.
Wang WH, Song SJ, Li LF, Zhang L, Yang SM, Zhang Q, Wang YY, Sun TT. Wang WH, et al. Eur J Dermatol. 2010 Sep-Oct;20(5):567-72. doi: 10.1684/ejd.2010.1015. Epub 2010 Jul 7. Eur J Dermatol. 2010. PMID: 20605767
Immunohistochemistry showed that the distributions, but not the densities of K1/K2/K10 were dramatically changed in the patients. Unlike normal expression of K1/K10 from suprabasal layers and K2 from upper spinous layers, K1/K10 was expressed later from upper spinou …
Immunohistochemistry showed that the distributions, but not the densities of K1/K2/K10 were dramatically changed in the patients. Unlike nor …
Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer.
Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Del Tacca M, Danesi R. Giovannetti E, et al. Mol Cancer Ther. 2006 Jun;5(6):1387-95. doi: 10.1158/1535-7163.MCT-06-0004. Mol Cancer Ther. 2006. PMID: 16818496 Review.
Chemotherapy has produced unsatisfactory results in pancreas cancer and novel approaches, including treatment tailoring by pharmacogenetic analysis and new molecular-targeted drugs, are required. The scarcity of effective therapies may reflect the lack of knowledge about t …
Chemotherapy has produced unsatisfactory results in pancreas cancer and novel approaches, including treatment tailoring by pharmacogenetic a …
41 results