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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1972 1
1973 1
1974 1
1975 1
1976 1
1977 2
1978 3
1979 2
1980 2
1981 4
1982 5
1983 6
1984 4
1985 10
1986 6
1987 5
1988 11
1989 14
1990 3
1991 11
1992 9
1993 6
1994 10
1995 6
1996 7
1997 6
1998 6
1999 8
2000 4
2001 11
2002 8
2003 15
2004 11
2005 12
2006 9
2007 17
2008 22
2009 12
2010 18
2011 23
2012 17
2013 11
2014 21
2015 22
2016 14
2017 25
2018 24
2019 18
2020 33
2021 25
2022 18
2023 14
2024 6

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508 results

Results by year

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Page 1
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL. Thenappan T, et al. BMJ. 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. BMJ. 2018. PMID: 29540357 Free PMC article. Review.
Progress has been made in identifying the causes of PAH and approving new drug therapies. A cancer-like increase in cell proliferation and resistance to apoptosis reflects acquired abnormalities of mitochondrial metabolism and dynamics. ...Complex changes in cytokin …
Progress has been made in identifying the causes of PAH and approving new drug therapies. A cancer-like increase in cell proliferatio …
Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.
Tefferi A, Vannucchi AM, Barbui T. Tefferi A, et al. Am J Hematol. 2024 Apr;99(4):697-718. doi: 10.1002/ajh.27216. Epub 2024 Jan 25. Am J Hematol. 2024. PMID: 38269572 Review.
Leukemic transformation rate at 10 years is <1% but might be higher in JAK2-mutated patients with extreme thrombocytosis and those with abnormal karyotype. TREATMENT: The main goal of therapy is to prevent thrombosis. In this regard, once-daily low-dose aspirin i …
Leukemic transformation rate at 10 years is <1% but might be higher in JAK2-mutated patients with extreme thrombocytosis and those with …
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A. Miehlke S, et al. Lancet Gastroenterol Hepatol. 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. Lancet Gastroenterol Hepatol. 2019. PMID: 30860066 Review.
These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes …
These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple …
16p13.11 microduplication in 45 new patients: refined clinical significance and genotype-phenotype correlations.
Allach El Khattabi L, Heide S, Caberg JH, Andrieux J, Doco Fenzy M, Vincent-Delorme C, Callier P, Chantot-Bastaraud S, Afenjar A, Boute-Benejean O, Cordier MP, Faivre L, Francannet C, Gerard M, Goldenberg A, Masurel-Paulet A, Mosca-Boidron AL, Marle N, Moncla A, Le Meur N, Mathieu-Dramard M, Plessis G, Lesca G, Rossi M, Edery P, Delahaye-Duriez A, De Pontual L, Tabet AC, Lebbar A, Suiro L, Ioos C, Natiq A, Chafai Elalaoui S, Missirian C, Receveur A, François-Fiquet C, Garnier P, Yardin C, Laroche C, Vago P, Sanlaville D, Dupont JM, Benzacken B, Pipiras E. Allach El Khattabi L, et al. J Med Genet. 2020 May;57(5):301-307. doi: 10.1136/jmedgenet-2018-105389. Epub 2018 Oct 4. J Med Genet. 2020. PMID: 30287593
This study aims to decipher the genotype-phenotype correlations to improve genetic counselling and patients' medical care. METHODS: We retrospectively analysed data from 16 013 patients referred to 12 genetic centers for DD, ID or ASD, and who had a chromosomal microarray …
This study aims to decipher the genotype-phenotype correlations to improve genetic counselling and patients' medical care. METHODS: W …
Current Challenges in Cancer Treatment.
Zugazagoitia J, Guedes C, Ponce S, Ferrer I, Molina-Pinelo S, Paz-Ares L. Zugazagoitia J, et al. Clin Ther. 2016 Jul;38(7):1551-66. doi: 10.1016/j.clinthera.2016.03.026. Epub 2016 May 2. Clin Ther. 2016. PMID: 27158009 Review.
Important challenges are still ongoing in both fields of cancer therapy. On the one hand, druggable genomic alterations are diverse and represent only small subsets of patients in certain tumor types, which limits testing their clinical impact in biomarker-driven clinical …
Important challenges are still ongoing in both fields of cancer therapy. On the one hand, druggable genomic alterations are diverse a …
Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia.
Albinger N, Pfeifer R, Nitsche M, Mertlitz S, Campe J, Stein K, Kreyenberg H, Schubert R, Quadflieg M, Schneider D, Kühn MWM, Penack O, Zhang C, Möker N, Ullrich E. Albinger N, et al. Blood Cancer J. 2022 Apr 13;12(4):61. doi: 10.1038/s41408-022-00660-2. Blood Cancer J. 2022. PMID: 35418180 Free PMC article.
Acute myeloid leukemia (AML) is a malignant disorder derived from neoplastic myeloid progenitor cells characterized by abnormal proliferation and differentiation. Although novel therapeutics have recently been introduced, AML remains a therapeutic challenge w …
Acute myeloid leukemia (AML) is a malignant disorder derived from neoplastic myeloid progenitor cells characterized by abnormal proli …
B Cells in Rheumatoid Arthritis:Pathogenic Mechanisms and Treatment Prospects.
Wu F, Gao J, Kang J, Wang X, Niu Q, Liu J, Zhang L. Wu F, et al. Front Immunol. 2021 Sep 28;12:750753. doi: 10.3389/fimmu.2021.750753. eCollection 2021. Front Immunol. 2021. PMID: 34650569 Free PMC article. Review.
The basic feature of RA is the body's immune system disorders, in which autoreactive CD4(+)T cells, pathogenic B cells, M1 macrophages, inflammatory cytokines, chemokines and autoantibodies abnormally increase in the body of RA patients B cell depletion therapy has …
The basic feature of RA is the body's immune system disorders, in which autoreactive CD4(+)T cells, pathogenic B cells, M1 macrophages, infl …
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P. Periman LM, et al. J Ocul Pharmacol Ther. 2020 Apr;36(3):137-146. doi: 10.1089/jop.2019.0060. Epub 2020 Mar 12. J Ocul Pharmacol Ther. 2020. PMID: 32175799 Free PMC article. Review.
Several therapeutics are available to break the vicious circle of DED and prevent chronic disease and progression, including immunosuppressive agents (steroids) and immunomodulators (cyclosporine and lifitegrast). ...In this study, we review the immunopathology of DED and …
Several therapeutics are available to break the vicious circle of DED and prevent chronic disease and progression, including immunosu …
Lipids in the tumor microenvironment: From cancer progression to treatment.
Corn KC, Windham MA, Rafat M. Corn KC, et al. Prog Lipid Res. 2020 Nov;80:101055. doi: 10.1016/j.plipres.2020.101055. Epub 2020 Aug 11. Prog Lipid Res. 2020. PMID: 32791170 Free PMC article. Review.
Over the past decade, the study of metabolic abnormalities in cancer cells has risen dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and nutrient-deplete tumor microenvironment or a distant tissue following metastasis. ...In this review …
Over the past decade, the study of metabolic abnormalities in cancer cells has risen dramatically. Cancer cells can thrive in challen …
2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjogren's syndrome: A consensus and data-driven methodology involving three international patient cohorts.
Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ, Mariette X; International Sjögren's Syndrome Criteria Working Group. Shiboski CH, et al. Ann Rheum Dis. 2017 Jan;76(1):9-16. doi: 10.1136/annrheumdis-2016-210571. Epub 2016 Oct 26. Ann Rheum Dis. 2017. PMID: 27789466
RESULTS: The final classification criteria are based on the weighted sum of five items: anti-SSA/Ro antibody positivity and focal lymphocytic sialadenitis with a focus score of 1 foci/4 mm(2), each scoring 3; an abnormal Ocular Staining Score of 5 (or van Bijstervel …
RESULTS: The final classification criteria are based on the weighted sum of five items: anti-SSA/Ro antibody positivity and focal lymphoc …
508 results