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Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A. Patnaik MM, et al. Am J Hematol. 2021 Mar 1;96(3):379-394. doi: 10.1002/ajh.26090. Epub 2021 Jan 28. Am J Hematol. 2021. PMID: 33428785 Free article. Review.
DISEASE OVERVIEW: Ring sideroblasts (RS) are erythroid precursors with abnormal perinuclear mitochondrial iron accumulation. ...Aspirin therapy is reasonable in MDS/MPN-RS-T, especially in the presence of JAK2V617F, but the value of platelet-lowering drugs re …
DISEASE OVERVIEW: Ring sideroblasts (RS) are erythroid precursors with abnormal perinuclear mitochondrial iron accumulation. . …
Proposal of criteria for dyserythropoiesis in the diagnosis of myelodysplastic syndromes.
Kawai N, Matsuda A, Jinnai I, Ichimura T, Kayano H, Okamura D, Ishikawa M, Maeda T, Hata T, Miyazaki Y, Asou N, Bessho M, Tomonaga M. Kawai N, et al. Int J Hematol. 2016 Feb;103(2):227-33. doi: 10.1007/s12185-015-1916-8. Epub 2015 Nov 25. Int J Hematol. 2016. PMID: 26608365
In present study, mild megaloblastic erythroblasts were specifically named 'red cell with abnormal chromatin clumping (RCACC)'. RCACC 10 % in erythroblasts was observed in 29 % of ITP patients and 58 % of HA patients. ...
In present study, mild megaloblastic erythroblasts were specifically named 'red cell with abnormal chromatin clumping (RCACC)' …
Clinical potential for noninvasive prenatal diagnosis through detection of fetal cells in maternal blood.
Purwosunu Y, Sekizawa A, Koide K, Okazaki S, Farina A, Okai T. Purwosunu Y, et al. Taiwan J Obstet Gynecol. 2006 Mar;45(1):10-20. doi: 10.1016/S1028-4559(09)60184-4. Taiwan J Obstet Gynecol. 2006. PMID: 17272202 Free article. Review.
Fetal cells circulate in maternal blood and are considered a suitable means by which to detect fetal genetic and chromosomal abnormalities. ...A more recent study has demonstrated the efficiency and success of recovery of NRBCs using a galactose-specific lectin, bas …
Fetal cells circulate in maternal blood and are considered a suitable means by which to detect fetal genetic and chromosomal abnor …
Fetal cells in maternal blood: state of the art for non-invasive prenatal diagnosis.
Ho SS, O'Donoghue K, Choolani M. Ho SS, et al. Ann Acad Med Singap. 2003 Sep;32(5):597-603; quiz 604. Ann Acad Med Singap. 2003. PMID: 14626786 Review.
Development of non-invasive methods for obtaining intact fetal cells would allow accurate prenatal diagnosis for aneuploidy and single gene disorders, without the attendant risks associated with invasive testing, and would increase the uptake of prenatal diagnosis by women …
Development of non-invasive methods for obtaining intact fetal cells would allow accurate prenatal diagnosis for aneuploidy and singl …
Clinical and morphological criteria for the diagnosis of prefibrotic idiopathic (primary) myelofibrosis.
Thiele J, Kvasnicka HM, Zankovich R, Diehl V. Thiele J, et al. Ann Hematol. 2001 Mar;80(3):160-5. doi: 10.1007/s002770000278. Ann Hematol. 2001. PMID: 11320901
Peripheral blood films revealed, only very sparsely, tear drop cells and a few erythroid and myeloid precursors, but no definite leukoerythroblastic reaction. ...Megakaryopoiesis was the most prominent diagnostic hallmark to distinguish initial-prefibrotic IMF from …
Peripheral blood films revealed, only very sparsely, tear drop cells and a few erythroid and myeloid precursors, but no defini …
Megakaryocytes harbour the del(5q) abnormality despite complete clinical and cytogenetic remission induced by lenalidomide treatment.
Scharenberg C, Jansson M, Saft L, Hellström-Lindberg E. Scharenberg C, et al. Br J Haematol. 2018 Feb;180(4):526-533. doi: 10.1111/bjh.15094. Epub 2018 Jan 29. Br J Haematol. 2018. PMID: 29377069 Free article.
The mechanisms underlying lenalidomide-resistance of del(5q) MDS stem cells remain to be elucidated and may include cell-intrinsic as well as microenvironmental causes. ...Using fluorescence in situ hybridisation analysis on flow-sorted stem- and progenitor p …
The mechanisms underlying lenalidomide-resistance of del(5q) MDS stem cells remain to be elucidated and may include cell-intri …
Culture of fetal cells from maternal blood for prenatal diagnosis.
Elicha Gussin HA, Elias S. Elicha Gussin HA, et al. Hum Reprod Update. 2002 Nov-Dec;8(6):523-7. doi: 10.1093/humupd/8.6.523. Hum Reprod Update. 2002. PMID: 12498422
One method that is currently being explored involves culturing fetal cells. Developing conditions which allow the number of fetal-derived cells to expand in culture and the number of maternally derived cells to be suppressed in culture may lead to a new selec …
One method that is currently being explored involves culturing fetal cells. Developing conditions which allow the number of fetal-der …
Prenatal diagnosis using fetal cells from the maternal circulation.
Lamvu G, Kuller JA. Lamvu G, et al. Obstet Gynecol Surv. 1997 Jul;52(7):433-7. doi: 10.1097/00006254-199707000-00022. Obstet Gynecol Surv. 1997. PMID: 9219277 Review.
We discuss the various methods that have been used to isolate these cells. Nucleated red blood cells have emerged as the ideal fetal cell type. This is because they have the DNA material necessary for genetic analysis, they are consistently present in materna …
We discuss the various methods that have been used to isolate these cells. Nucleated red blood cells have emerged as the ideal …
Current diagnostic criteria for the chronic myeloproliferative disorders (MPD) essential thrombocythemia (ET), polycythemia vera (PV) and chronic idiopathic myelofibrosis (CIMF).
Michiels JJ, Bernema Z, Van Bockstaele D, De Raeve H, Schroyens W. Michiels JJ, et al. Pathol Biol (Paris). 2007 Mar;55(2):92-104. doi: 10.1016/j.patbio.2006.06.002. Epub 2006 Aug 21. Pathol Biol (Paris). 2007. PMID: 16919893 Review.
As the clinical PVSG and the pathological WHO criteria show significant shortcomings, an updated set of European Clinical and Pathological (ECP) criteria combined with currently available biological and molecular markers are proposed to much better distinct true ET from early PV …
As the clinical PVSG and the pathological WHO criteria show significant shortcomings, an updated set of European Clinical and Pathological ( …
26 results