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Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.
Hypertension. 2023 Jul;80(7):1555-1567. doi: 10.1161/HYPERTENSIONAHA.123.20921. Epub 2023 May 1.
Hypertension. 2023.
PMID: 37125608
BACKGROUND: Primary aldosteronism is frequently caused by an adrenocortical aldosterone-producing adenoma (APA) carrying a somatic mutation that drives aldosterone overproduction. ...We exploited these differences to decipher the roles of transcriptome and metabolome repro …
BACKGROUND: Primary aldosteronism is frequently caused by an adrenocortical aldosterone-producing adenoma (APA) carrying a somatic mu …
Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.
Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, Tezuka Y, Morimoto R, Nakamura Y, Satoh F, Suzuki H, Kwon GE, Choi MH, Sasano H.
Harashima S, et al.
J Steroid Biochem Mol Biol. 2022 Jul;221:106116. doi: 10.1016/j.jsbmb.2022.106116. Epub 2022 May 6.
J Steroid Biochem Mol Biol. 2022.
PMID: 35533918
Aldosterone-producing adenoma (APA) is histologically composed of clear and compact tumor cells. ...In GC-MS analysis, most cholesterol precursors and metabolites, except for lanosterol, and their metabolic ratios (= concentration of cholesterol/ precursor) were hig …
Aldosterone-producing adenoma (APA) is histologically composed of clear and compact tumor cells. ...In GC-MS analysis, most ch …
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Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.
Azizan EA, Lam BY, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ.
Azizan EA, et al.
J Clin Endocrinol Metab. 2012 May;97(5):E819-29. doi: 10.1210/jc.2011-2965. Epub 2012 Mar 22.
J Clin Endocrinol Metab. 2012.
PMID: 22442279
OBJECTIVES: The objectives of this study were the following: 1) to compare transcriptional profiles in APA and adjacent adrenal gland (AAG); 2) to test whether gene expression profile clusters with different cell histology; and 3) to measure the frequency of KCNJ5 m …
OBJECTIVES: The objectives of this study were the following: 1) to compare transcriptional profiles in APA and adjacent adrenal gland …
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Immunocytochemical differential diagnosis of adrenocortical neoplasms using the monoclonal antibody D11.
Schröder S, Niendorf A, Achilles E, Dietel M, Padberg BC, Beisiegel U, Dralle H, Bressel M, Klöppel G.
Schröder S, et al.
Virchows Arch A Pathol Anat Histopathol. 1990;417(2):89-96. doi: 10.1007/BF02190525.
Virchows Arch A Pathol Anat Histopathol. 1990.
PMID: 2114700
The monoclonal antibody D11 is a valuable aid in the accurate typing of adrenal tumours as, in formalin-fixed, paraffin-embedding material, strong nuclear D11 positivity was observed only in adrenocortical cells in 190 neoplasms (including 100 adrenal tumours …
The monoclonal antibody D11 is a valuable aid in the accurate typing of adrenal tumours as, in formalin-fixed, paraffin-embedding mat …
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