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Role of Fiber Shaft Length in Tumor Targeting with Ad5/3 Vectors.
Richter M, Wang H, Lieber A. Richter M, et al. Genes (Basel). 2022 Nov 7;13(11):2056. doi: 10.3390/genes13112056. Genes (Basel). 2022. PMID: 36360292 Free PMC article.
We constructed Ad5/3L (with the "long" Ad5 shaft) and Ad5/3S (with the "short" Ad3 shaft) expressing GFP or luciferase. In in vitro studies we found that coagulation factor X, which is known to mediate undesired hepatocyte transduction of Ad5, enhances the tr …
We constructed Ad5/3L (with the "long" Ad5 shaft) and Ad5/3S (with the "short" Ad3 shaft) expressing GFP or luciferase. In in vitro studies …
Engineering Human Cells Expressing CRISPR/Cas9-Synergistic Activation Mediators for Recombinant Protein Production.
Feser CJ, Williams JM, Lammers DT, Bingham JR, Eckert MJ, Tolar J, Osborn MJ. Feser CJ, et al. Int J Mol Sci. 2023 May 9;24(10):8468. doi: 10.3390/ijms24108468. Int J Mol Sci. 2023. PMID: 37239814 Free PMC article.
We integrated the components of the SAM system into human HEK293, HKB11, SK-HEP1, and HEP-g2 cells using coagulation factor X (FX) and fibrinogen (FBN) as proof of concept. ...
We integrated the components of the SAM system into human HEK293, HKB11, SK-HEP1, and HEP-g2 cells using coagulation factor …
Characterization of a Missense Mutation in the Catalytic Domain and a Splicing Mutation of Coagulation Factor X Compound Heterozygous in a Chinese Pedigree.
Feng Y, Ma J, Tang LV, Lin W, Tao Y, Cheng Z, Hu Y. Feng Y, et al. Genes (Basel). 2021 Sep 27;12(10):1521. doi: 10.3390/genes12101521. Genes (Basel). 2021. PMID: 34680916 Free PMC article.
BACKGROUND: Congenital coagulation factor X (FX) deficiency is a rare bleeding disorder with an incidence of one in one million caused by mutations in the FX-coding gene(F10), leading to abnormal coagulation activity and a tendency for severe hemorrhage. ...
BACKGROUND: Congenital coagulation factor X (FX) deficiency is a rare bleeding disorder with an incidence of one in one …
Human AdV-20-42-42, a Promising Novel Adenoviral Vector for Gene Therapy and Vaccine Product Development.
Ballmann MZ, Raus S, Engelhart R, Kaján GL, Beqqali A, Hadoke PWF, van der Zalm C, Papp T, John L, Khan S, Boedhoe S, Danskog K, Frängsmyr L, Custers J, Bakker WAM, van der Schaar HM, Arnberg N, Lemckert AAC, Havenga M, Baker AH. Ballmann MZ, et al. J Virol. 2021 Oct 27;95(22):e0038721. doi: 10.1128/JVI.00387-21. Epub 2021 Sep 1. J Virol. 2021. PMID: 34469243 Free PMC article.
Furthermore, the HAdV-20-42-42 vector was potent in transducing human and murine cardiovascular cells and tissues, irrespective of the presence of blood coagulation factor X. In vivo characterizations demonstrate that when delivered intravenously (i.v.) in mi …
Furthermore, the HAdV-20-42-42 vector was potent in transducing human and murine cardiovascular cells and tissues, irrespective of the prese …
Transduction Enhancers Enable Efficient Human Adenovirus Type 5-Mediated Gene Transfer into Human Multipotent Mesenchymal Stromal Cells.
Nilson R, Lübbers O, Weiß L, Singh K, Scharffetter-Kochanek K, Rojewski M, Schrezenmeier H, Zeplin PH, Funk W, Krutzke L, Kochanek S, Kritzinger A. Nilson R, et al. Viruses. 2021 Jun 12;13(6):1136. doi: 10.3390/v13061136. Viruses. 2021. PMID: 34204818 Free PMC article.
Here we present several transduction enhancers that strongly enhance HAdV-5-mediated gene transfer into both bone marrow- and adipose tissue-derived hMSCs. Polybrene, poly-l-lysine, human lactoferrin, human blood coagulation factor X, spermine, and spermidine …
Here we present several transduction enhancers that strongly enhance HAdV-5-mediated gene transfer into both bone marrow- and adipose tissue …