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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1990 1
1993 2
1996 2
1997 2
1998 5
1999 8
2000 3
2001 7
2002 6
2003 7
2004 3
2005 10
2006 11
2007 16
2008 17
2009 14
2010 13
2011 12
2012 13
2013 13
2014 15
2015 16
2016 14
2017 10
2018 10
2019 19
2020 18
2021 18
2022 17
2023 12
2024 5

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278 results

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Page 1
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS. Cappell MS. Gastroenterol Clin North Am. 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. Gastroenterol Clin North Am. 2008. PMID: 18313537 Review.
Conventional adenomas arise from mutation of the APC gene; progression to colon cancer is a multistep process. The fundamental genetic defect in serrated adenomas is unknown. Environmental factors can increase the risk for colon cancer. Advanced colon cancer …
Conventional adenomas arise from mutation of the APC gene; progression to colon cancer is a multistep process. The fundamental geneti …
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer.
Zhu G, Pei L, Xia H, Tang Q, Bi F. Zhu G, et al. Mol Cancer. 2021 Nov 6;20(1):143. doi: 10.1186/s12943-021-01441-4. Mol Cancer. 2021. PMID: 34742312 Free PMC article. Review.
Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. ...Due to the presence of KRAS mutations, this group of CRC patients requires more precise therapies. However, KRAS was historically thought to be an undruggable t …
Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. ...Due to the presence of KRAS …
Genotype-first approach to identify associations between CDH1 germline variants and cancer phenotypes: a multicentre study by the European Reference Network on Genetic Tumour Risk Syndromes.
Garcia-Pelaez J, Barbosa-Matos R, Lobo S, Dias A, Garrido L, Castedo S, Sousa S, Pinheiro H, Sousa L, Monteiro R, Maqueda JJ, Fernandes S, Carneiro F, Pinto N, Lemos C, Pinto C, Teixeira MR, Aretz S, Bajalica-Lagercrantz S, Balmaña J, Blatnik A, Benusiglio PR, Blanluet M, Bours V, Brems H, Brunet J, Calistri D, Capellá G, Carrera S, Colas C, Dahan K, de Putter R, Desseignés C, Domínguez-Garrido E, Egas C, Evans DG, Feret D, Fewings E, Fitzgerald RC, Coulet F, Garcia-Barcina M, Genuardi M, Golmard L, Hackmann K, Hanson H, Holinski-Feder E, Hüneburg R, Krajc M, Lagerstedt-Robinson K, Lázaro C, Ligtenberg MJL, Martínez-Bouzas C, Merino S, Michils G, Novaković S, Patiño-García A, Ranzani GN, Schröck E, Silva I, Silveira C, Soto JL, Spier I, Steinke-Lange V, Tedaldi G, Tejada MI, Woodward ER, Tischkowitz M, Hoogerbrugge N, Oliveira C. Garcia-Pelaez J, et al. Lancet Oncol. 2023 Jan;24(1):91-106. doi: 10.1016/S1470-2045(22)00643-X. Epub 2022 Nov 24. Lancet Oncol. 2023. PMID: 36436516 Free PMC article.
FINDINGS: From 1971 phenotypes (contributed by 854 probands and 1021 relatives aged 1-93 years), 460 had gastric and breast cancer histology available. ...Of the remaining 40 (23%) families, who did not fulfil the 2015 criteria, 11 fulfilled the 2020 HDGC criteria, …
FINDINGS: From 1971 phenotypes (contributed by 854 probands and 1021 relatives aged 1-93 years), 460 had gastric and breast cancer …
Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations.
Xin J, Du M, Gu D, Jiang K, Wang M, Jin M, Hu Y, Ben S, Chen S, Shao W, Li S, Chu H, Zhu L, Li C, Chen K, Ding K, Zhang Z, Shen H, Wang M. Xin J, et al. Genome Med. 2023 Jan 24;15(1):4. doi: 10.1186/s13073-023-01156-9. Genome Med. 2023. PMID: 36694225 Free PMC article.
CONCLUSIONS: In summary, we systemically constructed an EAS-EUR PRS to effectively stratify colorectal cancer risk, which highlighted its clinical implication among diverse ancestries. Importantly, these findings also supported that a healthy lifestyle could reduce …
CONCLUSIONS: In summary, we systemically constructed an EAS-EUR PRS to effectively stratify colorectal cancer risk, which high …
Current Approaches to Germline Cancer Genetic Testing.
Stoffel EM, Carethers JM. Stoffel EM, et al. Annu Rev Med. 2020 Jan 27;71:85-102. doi: 10.1146/annurev-med-052318-101009. Epub 2019 Nov 22. Annu Rev Med. 2020. PMID: 31756137 Review.
Deleterious germline variants in cancer predisposition genes are implicated in 1 in 10 cases of advanced cancer. ...Expanded access to clinical genetic testing will improve identification of individuals with genetic predisposition to cancer and provide …
Deleterious germline variants in cancer predisposition genes are implicated in 1 in 10 cases of advanced cancer. ...Exp …
Molecular Features and Clinical Management of Hereditary Gynecological Cancers.
Ueki A, Hirasawa A. Ueki A, et al. Int J Mol Sci. 2020 Dec 14;21(24):9504. doi: 10.3390/ijms21249504. Int J Mol Sci. 2020. PMID: 33327492 Free PMC article. Review.
Tumors that arise in the female reproductive system, such as ovaries and the uterus, overlap with hereditary cancers. Several hereditary cancer-related genes are important because they might lead to therapeutic targets. ...We also reviewed cancer-susceptib …
Tumors that arise in the female reproductive system, such as ovaries and the uterus, overlap with hereditary cancers. Several hereditary …
Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers.
Siskova A, Cervena K, Kral J, Hucl T, Vodicka P, Vymetalkova V. Siskova A, et al. Int J Mol Sci. 2020 May 5;21(9):3260. doi: 10.3390/ijms21093260. Int J Mol Sci. 2020. PMID: 32380676 Free PMC article. Review.
Colorectal cancer (CRC) is a malignant disease with an incidence of over 1.8 million new cases per year worldwide. ...In this work, we focused on both genetic and epigenetic changes associated with the development of colorectal adenomas into …
Colorectal cancer (CRC) is a malignant disease with an incidence of over 1.8 million new cases per year worldwid …
Contribution of Matrix Metalloproteinase-1 Genotypes to Colorectal Cancer in Taiwan.
Wu MH, Yueh TC, Chang WS, Tsai CW, Fu CK, Yang MD, Yu CC, Bau DT. Wu MH, et al. Cancer Genomics Proteomics. 2021 May-Jun;18(3):245-251. doi: 10.21873/cgp.20255. Epub 2021 Apr 23. Cancer Genomics Proteomics. 2021. PMID: 33893077 Free PMC article.
BACKGROUND/AIM: Matrix metalloproteinase-1 is responsible for extracellular matrix regulation, and its genetic role in colorectal cancer (CRC) is unclear. ...The 1G/1G genotype were statistically lower among CRC patients with lymph node metastasis (7.2%) than …
BACKGROUND/AIM: Matrix metalloproteinase-1 is responsible for extracellular matrix regulation, and its genetic role in colorectal …
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R. Eng C, et al. Am Soc Clin Oncol Educ Book. 2019 Jan;39:216-225. doi: 10.1200/EDBK_237433. Epub 2019 May 17. Am Soc Clin Oncol Educ Book. 2019. PMID: 31099616 Free article. Review.
Increased acknowledgment of the importance of HPV vaccination as an anticancer vaccine should be encouraged. The present standard of care is primary chemoradiotherapy (CRT), which results in a high level of disease control for small, early-stage SCCA. ...Whenever po …
Increased acknowledgment of the importance of HPV vaccination as an anticancer vaccine should be encouraged. The present standard of care …
Gold (III) Derivatives in Colon Cancer Treatment.
Gurba A, Taciak P, Sacharczuk M, Młynarczuk-Biały I, Bujalska-Zadrożny M, Fichna J. Gurba A, et al. Int J Mol Sci. 2022 Jan 10;23(2):724. doi: 10.3390/ijms23020724. Int J Mol Sci. 2022. PMID: 35054907 Free PMC article. Review.
Cancer is one of the leading causes of morbidity and mortality worldwide. Colorectal cancer (CRC) is the third most frequently diagnosed cancer in men and the second in women. ...
Cancer is one of the leading causes of morbidity and mortality worldwide. Colorectal cancer (CRC) is the third most fre …
278 results