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Diagnosis and treatment of lipodystrophy: a step-by-step approach.
Araújo-Vilar D, Santini F. Araújo-Vilar D, et al. J Endocrinol Invest. 2019 Jan;42(1):61-73. doi: 10.1007/s40618-018-0887-z. Epub 2018 Apr 27. J Endocrinol Invest. 2019. PMID: 29704234 Free PMC article. Review.
Genes associated with many congenital forms of lipodystrophy have been identified that may assist in diagnosis. ...Metreleptin is approved in the United States as replacement therapy to treat the complications of leptin deficiency in patients with congenit …
Genes associated with many congenital forms of lipodystrophy have been identified that may assist in diagnosis. ...Metreleptin …
Treatment Options for Lipodystrophy in Children.
Mainieri F, Tagi VM, Chiarelli F. Mainieri F, et al. Front Endocrinol (Lausanne). 2022 May 4;13:879979. doi: 10.3389/fendo.2022.879979. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35600578 Free PMC article. Review.
Given the evidence of leptin deficiency in lipodystrophy syndromes, leptin replacement therapy has been considered as a treatment option. ...Recently, metreleptin was approved by Food and Drug Administration (FDA) for the treatment of generalized lipodystr …
Given the evidence of leptin deficiency in lipodystrophy syndromes, leptin replacement therapy has been considered as a treatm …
Clinical Features and Management of Non-HIV-Related Lipodystrophy in Children: A Systematic Review.
Gupta N, Asi N, Farah W, Almasri J, Barrionuevo P, Alsawas M, Wang Z, Haymond MW, Brown RJ, Murad MH. Gupta N, et al. J Clin Endocrinol Metab. 2017 Feb 1;102(2):363-374. doi: 10.1210/jc.2016-2271. J Clin Endocrinol Metab. 2017. PMID: 27967300 Free PMC article. Review.
CONTEXT: Lipodystrophy syndromes are characterized by generalized or partial absence of adipose tissue. ...Generalized fat loss involving face, neck, abdomen, thorax, and upper and lower limbs was explicitly reported in 65% to 93% of patients with congenit …
CONTEXT: Lipodystrophy syndromes are characterized by generalized or partial absence of adipose tissue. ...Generalized …
Clinical classification and treatment of congenital and acquired lipodystrophy.
Chan JL, Oral EA. Chan JL, et al. Endocr Pract. 2010 Mar-Apr;16(2):310-23. doi: 10.4158/EP09154.RA. Endocr Pract. 2010. PMID: 20061300 Review.
OBJECTIVE: To review the initial clinical manifestations of congenital and acquired lipodystrophy syndromes, discuss novel classifications associated with genetic mutations, and assess currently available therapeutic options for patients with lipodystrophy …
OBJECTIVE: To review the initial clinical manifestations of congenital and acquired lipodystrophy syndromes, discuss novel cla …
Genotype-phenotype correlations of Berardinelli-Seip congenital lipodystrophy and novel candidate genes prediction.
Ren M, Shi J, Jia J, Guo Y, Ni X, Shi T. Ren M, et al. Orphanet J Rare Dis. 2020 Apr 29;15(1):108. doi: 10.1186/s13023-020-01383-y. Orphanet J Rare Dis. 2020. PMID: 32349771 Free PMC article.
BACKGROUND: Berardinelli-Seip congenital lipodystrophy (BSCL) is a heterogeneous autosomal recessive disorder characterized by an almost total lack of adipose tissue in the body. ...
BACKGROUND: Berardinelli-Seip congenital lipodystrophy (BSCL) is a heterogeneous autosomal recessive disorder characterized by …
Metreleptin Treatment in Patients with Non-HIV Associated Lipodystrophy.
Akinci G, Akinci B. Akinci G, et al. Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):74-8. doi: 10.2174/1574892811666151111142554. Recent Pat Endocr Metab Immune Drug Discov. 2015. PMID: 26556498 Review.
Lipodystrophies are a heterogeneous group of disorders characterized by congenital or acquired loss of adipose tissue. Recently, metreleptin, a recombinant human leptin analog, has been approved for the treatment of patients with generalized lipodystrophy. .. …
Lipodystrophies are a heterogeneous group of disorders characterized by congenital or acquired loss of adipose tissue. Recently, metr …
Genetic basis of lipodystrophies and management of metabolic complications.
Agarwal AK, Garg A. Agarwal AK, et al. Annu Rev Med. 2006;57:297-311. doi: 10.1146/annurev.med.57.022605.114424. Annu Rev Med. 2006. PMID: 16409151 Review.
Among genetic lipodystrophies, fat loss is observed either from birth, as in congenital generalized lipodystrophy, or later in life, as in familial partial lipodystrophy. ...We discuss features of autosomal recessive and dominant types of lipodystrophi …
Among genetic lipodystrophies, fat loss is observed either from birth, as in congenital generalized lipodystrophy, or l …
Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.
Brown RJ, Oral EA, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Gorden P. Brown RJ, et al. Endocrine. 2018 Jun;60(3):479-489. doi: 10.1007/s12020-018-1589-1. Epub 2018 Apr 12. Endocrine. 2018. PMID: 29644599 Free PMC article.
PURPOSE: The purpose of this study is to summarize the effectiveness and safety of metreleptin in patients with congenital or acquired generalized lipodystrophy. METHODS: Patients (n = 66) aged 6 months had lipodystrophy, low circulating leptin, and 1 …
PURPOSE: The purpose of this study is to summarize the effectiveness and safety of metreleptin in patients with congenital or acquire …
Recombinant human leptin treatment in genetic lipodystrophic syndromes: the long-term Spanish experience.
Araujo-Vilar D, Sánchez-Iglesias S, Guillín-Amarelle C, Castro A, Lage M, Pazos M, Rial JM, Blasco J, Guillén-Navarro E, Domingo-Jiménez R, del Campo MR, González-Méndez B, Casanueva FF. Araujo-Vilar D, et al. Endocrine. 2015 May;49(1):139-47. doi: 10.1007/s12020-014-0450-4. Epub 2014 Nov 4. Endocrine. 2015. PMID: 25367549 Free PMC article.
In uncommon lipodystrophies, these complications frequently are difficult to control with conventional therapeutic approaches. This retrospective study addressed the effectiveness of recombinant methionyl leptin (metreleptin) for improving glucose metabolism, lipid profile …
In uncommon lipodystrophies, these complications frequently are difficult to control with conventional therapeutic approaches. This r …