Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 1
2013 1
2016 1
2017 1
2019 1
2020 1
2021 1
2022 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

7 results

Results by year

Filters applied: . Clear all
Page 1
ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer.
Johnson RM, Qu X, Lin CF, Huw LY, Venkatanarayan A, Sokol E, Ou FS, Ihuegbu N, Zill OA, Kabbarah O, Wang L, Bourgon R, de Sousa E Melo F, Bolen C, Daemen A, Venook AP, Innocenti F, Lenz HJ, Bais C. Johnson RM, et al. Nat Commun. 2022 Sep 19;13(1):5478. doi: 10.1038/s41467-022-33172-5. Nat Commun. 2022. PMID: 36117191 Free PMC article.
Most colorectal (CRC) tumors are dependent on EGFR/KRAS/BRAF/MAPK signaling activation. ...In addition, we find that patients with ARID1A mutations, at baseline, are associated with worse outcome when treated with cetuximab- but not bevacizumab-containing therapies; …
Most colorectal (CRC) tumors are dependent on EGFR/KRAS/BRAF/MAPK signaling activation. ...In addition, we find that patients with AR …
Current Microsatellite Instability Testing in Management of Colorectal Cancer.
Sun BL. Sun BL. Clin Colorectal Cancer. 2021 Mar;20(1):e12-e20. doi: 10.1016/j.clcc.2020.08.001. Epub 2020 Aug 10. Clin Colorectal Cancer. 2021. PMID: 32888812 Review.
Colorectal cancer (CRC) is the third most common cancer worldwide. In the past decade, mismatch repair deficiency (dMMR), manifested as microsatellite instability-high (MSI-H), has been recognized as a distinct mechanism promoting tumorigenesis in 15% of CRCs including 3% …
Colorectal cancer (CRC) is the third most common cancer worldwide. In the past decade, mismatch repair deficiency (dMMR), manifested …
Review article: Lynch Syndrome-a mechanistic and clinical management update.
Curtius K, Gupta S, Boland CR. Curtius K, et al. Aliment Pharmacol Ther. 2022 Apr;55(8):960-977. doi: 10.1111/apt.16826. Epub 2022 Mar 21. Aliment Pharmacol Ther. 2022. PMID: 35315099 Free PMC article. Review.
RESULTS: LS tumours are characterised by unique pathogenesis, ultimately resulting in hypermutation, microsatellite instability and high immunogenicity that has significant implications for cancer risk, clinical presentation, treatment and surveillance. LS is one of the mo …
RESULTS: LS tumours are characterised by unique pathogenesis, ultimately resulting in hypermutation, microsatellite instability and h …
Spectrum of Gene Mutations in Colorectal Cancer: Implications for Treatment.
Dienstmann R, Tabernero J. Dienstmann R, et al. Cancer J. 2016 May-Jun;22(3):149-55. doi: 10.1097/PPO.0000000000000191. Cancer J. 2016. PMID: 27341591 Review.
Gene mutations acquired during colorectal carcinogenesis remain drivers of cancer progression in the metastatic setting. ...With advances in drug development and better understanding of the dynamics of target inhibition, additional gene alterations are now promising positi …
Gene mutations acquired during colorectal carcinogenesis remain drivers of cancer progression in the metastatic setting. ...With adva …
Immunotherapy holds the key to cancer treatment and prevention in constitutional mismatch repair deficiency (CMMRD) syndrome.
Westdorp H, Kolders S, Hoogerbrugge N, de Vries IJM, Jongmans MCJ, Schreibelt G. Westdorp H, et al. Cancer Lett. 2017 Sep 10;403:159-164. doi: 10.1016/j.canlet.2017.06.018. Epub 2017 Jun 20. Cancer Lett. 2017. PMID: 28645564 Free article. Review.
Monoallelic germline mutations in one of the DNA mismatch repair (MMR) genes cause Lynch syndrome, with a high lifetime risks of colorectal and endometrial cancer at adult age. Less well known, is the constitutional mismatch repair deficiency (CMMRD) syndrome caused by bia …
Monoallelic germline mutations in one of the DNA mismatch repair (MMR) genes cause Lynch syndrome, with a high lifetime risks of colorect …
Role of immune checkpoint inhibitors in the treatment of colorectal cancer: focus on nivolumab.
Jácome AA, Eng C. Jácome AA, et al. Expert Opin Biol Ther. 2019 Dec;19(12):1247-1263. doi: 10.1080/14712598.2019.1680636. Epub 2019 Oct 23. Expert Opin Biol Ther. 2019. PMID: 31642347 Review.
Introduction: Metastatic colorectal cancer (mCRC) is a challenging disease, whose systemic therapy has traditionally been based on a generalized population of patients, with unsatisfactory clinical outcomes. Immunotherapy has been shown to be efficacious in hyper …
Introduction: Metastatic colorectal cancer (mCRC) is a challenging disease, whose systemic therapy has traditionally been base …
Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis.
Christie M, Jorissen RN, Mouradov D, Sakthianandeswaren A, Li S, Day F, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Burgess AW, Busam D, Zhao Q, Strausberg RL, Simpson AJ, Tomlinson IP, Gibbs P, Sieber OM. Christie M, et al. Oncogene. 2013 Sep 26;32(39):4675-82. doi: 10.1038/onc.2012.486. Epub 2012 Oct 22. Oncogene. 2013. PMID: 23085758 Free PMC article.
Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (CRC). Mutations may not be fully inactivating, instead producing WNT/beta-catenin signalling levels 'just-right' for tumourigenesis. ...
Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (CRC) …