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Year Number of Results
2003 2
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2010 2
2015 1
2019 1
2020 2
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Functioning pre- and post-treatment in schizophrenia; further investigations into lead time bias and duration of untreated psychosis.
Albert N, Hansen HG, Starzer M, Nordentoft M, Hjorthøj C. Albert N, et al. Schizophr Res. 2023 Feb;252:287-293. doi: 10.1016/j.schres.2023.01.003. Epub 2023 Jan 25. Schizophr Res. 2023. PMID: 36706472
CONCLUSION: In this study, we did not find evidence of a lead-time bias, but rather found that onset of treatment occurs at the time when participants level of functioning was most impaired, and consequently was not at random....
CONCLUSION: In this study, we did not find evidence of a lead-time bias, but rather found that onset of treatment occurs at the time when pa …
Considering lead-time bias in evaluating the effectiveness of lung cancer screening with real-world data.
Yang SC, Wang JD, Wang SY. Yang SC, et al. Sci Rep. 2021 Jun 9;11(1):12180. doi: 10.1038/s41598-021-91852-6. Sci Rep. 2021. PMID: 34108586 Free PMC article.
This study developed a method using a nationwide cancer registry and stage shift from trial for the adjustment of lead-time bias. 78,897 Taiwanese nationwide lung cancer patients aged 55-82 were matched with 788,820 referents randomly selected from the general popul …
This study developed a method using a nationwide cancer registry and stage shift from trial for the adjustment of lead-time bias. 78, …
Prolonged time to treatment initiation in advanced pancreatic cancer patients has no major effect on treatment outcome: a retrospective cohort study controlled for lead time bias and waiting time paradox.
Kruger S, Schirle K, Haas M, Crispin A, Schirra J, Mayerle J, D'Haese JG, Kunz WG, Ricke J, Ormanns S, Kirchner T, Kobold S, Ilmer M, Gebauer L, Westphalen CB, von Bergwelt-Baildon M, Werner J, Heinemann V, Boeck S. Kruger S, et al. J Cancer Res Clin Oncol. 2020 Feb;146(2):391-399. doi: 10.1007/s00432-019-03061-4. Epub 2019 Oct 23. J Cancer Res Clin Oncol. 2020. PMID: 31642961
CONCLUSION: While a timely work-up of advanced PC patients remains important, delays in treatment initiation due to repeated biopsies, inclusion in a clinical study or transfer to a specialized cancer center appear to be justified in light of the absence of a strong advers …
CONCLUSION: While a timely work-up of advanced PC patients remains important, delays in treatment initiation due to repeated biopsies, inclu …
Endocrine immune-related adverse event is a prognostic biomarker independent of lead-time bias.
Ishidoya M, Makiguchi T, Tanaka H, Miura T, Nunomura Y, Miura D, Morimoto T, Hasegawa Y, Taima K, Tasaka S. Ishidoya M, et al. Lung Cancer. 2024 Jun;192:107790. doi: 10.1016/j.lungcan.2024.107790. Epub 2024 Apr 9. Lung Cancer. 2024. PMID: 38696920 Free article.
OBJECTIVES: Immune-related adverse events (irAEs) are known to be associated with clinical efficacy and better prognoses in patients receiving immune checkpoint inhibitors. ...
OBJECTIVES: Immune-related adverse events (irAEs) are known to be associated with clinical efficacy and better prognoses in patients …
Pancreatectomy Versus Conservative Management for Pancreatic Cancer: A Question of Lead-time Bias.
Kendal WS. Kendal WS. Am J Clin Oncol. 2015 Oct;38(5):483-8. doi: 10.1097/COC.0b013e3182a533ea. Am J Clin Oncol. 2015. PMID: 24064752
If most of these individuals had occult metastases at diagnosis, which manifested later and caused death at similar ages as the nonsurgical cohort, their survival from time of diagnosis would appear speciously improved. A randomized controlled trial would be necessa …
If most of these individuals had occult metastases at diagnosis, which manifested later and caused death at similar ages as the nonsurgical …
Evaluation of the Houston biochemical relapse definition in men treated with prolonged neoadjuvant and adjuvant androgen ablation and assessment of follow-up lead-time bias.
Pickles T, Kim-Sing C, Morris WJ, Tyldesley S, Paltiel C. Pickles T, et al. Int J Radiat Oncol Biol Phys. 2003 Sep 1;57(1):11-8. doi: 10.1016/s0360-3016(03)00439-5. Int J Radiat Oncol Biol Phys. 2003. PMID: 12909209
RESULTS: For all patients, the Houston definition was more accurate (79.5%) than the ASTRO (76.7%) or Vancouver (77.2%) definitions in predicting subsequent clinical relapse. The Houston definition was superior to the ASTRO definition in those treated both with and without …
RESULTS: For all patients, the Houston definition was more accurate (79.5%) than the ASTRO (76.7%) or Vancouver (77.2%) definitions in predi …
Surveillance for the detection of recurrent ovarian cancer: survival impact or lead-time bias?
Tanner EJ, Chi DS, Eisenhauer EL, Diaz-Montes TP, Santillan A, Bristow RE. Tanner EJ, et al. Gynecol Oncol. 2010 May;117(2):336-40. doi: 10.1016/j.ygyno.2010.01.014. Epub 2010 Feb 12. Gynecol Oncol. 2010. PMID: 20153027
OBJECTIVE: To compare the survival impact of diagnosing recurrent disease by routine surveillance testing versus clinical symptomatology in patients with recurrent epithelial ovarian cancer (EOC) who have achieved a complete response following primary therapy. METHODS: We …
OBJECTIVE: To compare the survival impact of diagnosing recurrent disease by routine surveillance testing versus clinical symptomatol …
Histopathologic extent of cervical intraepithelial neoplasia 3 lesions in the atypical squamous cells of undetermined significance low-grade squamous intraepithelial lesion triage study: implications for subject safety and lead-time bias.
Sherman ME, Wang SS, Tarone R, Rich L, Schiffman M. Sherman ME, et al. Cancer Epidemiol Biomarkers Prev. 2003 Apr;12(4):372-9. Cancer Epidemiol Biomarkers Prev. 2003. PMID: 12692113 Clinical Trial.
We assessed this hypothesis in a masked histopathologic review of 330 CIN3 lesions in the ASCUS LSILTriage Study, focusing on ASCUS referrals. ASCUS referrals underwent randomized management [colposcopy for repeat cytology of high-grade squamous intraepithelial lesion (HSI …
We assessed this hypothesis in a masked histopathologic review of 330 CIN3 lesions in the ASCUS LSILTriage Study, focusing on ASCUS referral …
11 results